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Biomedical subjects

V A Shabanov

Publications and source records attributed to V A Shabanov.

15 recordsLinked to original sources
PubMed2001

[Changes in blood rheological properties in patients with hypertension].

AIM: To study hemorheology in patients with essential hypertension (EH), to improve EH treatment in terms of blood rheology. MATERIAL AND METHODS: Blood rheology, microcirculation, lipid plasm spectrum, central hemodynamics were studied in 90 patients with mild and 83 patients with moderate or severe EH as well as 30 healthy controls before and after treatment (hypotensive drugs, essential phospholipids, intravenous laser blood radiation, plasmapheresis). RESULTS: Hemorrheological disorders (subnormal deformability of the red cells and elastoviscosity of their membranes, disk-spherical transformation and hyperaggregation of blood cells, high dynamic viscosity) correlated with the disease severity, arterial pressure and total peripheral vascular resistance. Long-term (1-1.5 years) hypotensive therapy, especially with combination of beta-blockers with diuretics, has a negative effect on blood rheology. Optimisation of EH treatment in terms of blood rheology consists in using essential phospholipids in stable hypertension, intravenous laser radiation in complicated hypertension, plasmapheresis in drug-resistant hypertension. Such an approach not only significantly improves hemorheology but also provides good clinical and hypotensive effects in 75-80% patients. CONCLUSION: Blood viscodynamics should be taken into consideration in individual treatment of hypertensive patients.

Adrenergic beta-Antagonists↗
PubMed1991

[Optimization of the treatment of patients with hypertensive disease from the rheological viewpoint].

The efficacy of various modes of correcting rheological disorders (membrane-protective agents, laser irradiation, plasmapheresis was compared in hypertensive patients. In 30% of the patients, the conventional antihypertensive therapy was demonstrated to deteriorate hemorheological parameters, which was due to its atherogenic impact on the blood lipid spectrum. Essential phospholipids, laser irradiation, and plasmapheresis, which are supplemented to the multimodality therapy promote a significant improvement of hemorheological parameters, which makes it possible to recommend them for management of hypertensive patients with a stable (essential phospholipids), complicated (laser irradiation), and refractory (plasmapheresis) course.

Adult↗
PubMed1991

[Microrheological disorders of erythrocytes in patients with hypertension].

The viscosity of blood and microrheological characteristics of erythrocytes (aggregation and disaggregation rates of erythrocytes, their deformity, mechanical resistance) were examined in patients with Stage III essential hypertension. There was a correlation between the mid-hemodynamic pressure and the erythrocyte deformity, on the one hand; and the total peripheral resistance and the erythrocyte deformity, on the other. The total peripheral resistance correlated with erythrocyte aggregation rates in patients with Stages I and II hypertension. It has been concluded that examining hemorheology in patients with hypertension is of significance and it is essential to correct rheological abnormalities.

Adult↗
PubMed1990

[The clinical importance of studying disorders in the rheological properties of the blood in hypertension patients].

Altogether 118 patients with stages I-III essential hypertension were examined for hemodynamics and rheologic blood properties: total viscosity, deformability, aggregation, form and mechanical resistance of red blood cells, plasma osmolality, hematocrit, and red blood cell count. The data obtained indicate that in patients suffering from essential hypertension, there occur consistent abnormalities of hemorheology, correlating with the disease stage and some hemodynamic parameters. Early changes in red blood cell deformability and their discospheric transformation turned out to be the most specific in patients with essential hypertension. Red blood cell aggregation and hydrodynamic deaggregation underwent alterations mainly in complicated disease patterns.

Adult↗
PubMed1983

[Microcirculation and rheology of cardiovascular diseases: physiological, clinical and pharmacological aspects].

Microcirculatory and rheologic disorders associated with neurocirculatory dystonia, essential hypertension and coronary disease are reported. The pathogenetic role of microcirculatory and rheologic disorders in cardiovascular diseases is outlined. The value of erythrocyte deformability for rheologic disorders is established. The efficiency of Trental treatment for coronary disease is demonstrated.

Adult↗
PubMed1980

[Primary venous hypertension as a form of neurocirculatory dystonia (clinical aspects and pathogenetic and treatment problems].

The work deals with the results of examination of 108 patients in whom venous hypertension was revealed in the absence of organic pathology and who had normal arterial pressure. The clinical picture is described. The authors distinguish a form of primary venous hypertension with or without hypervolemia. Some problems concerning the pathogenesis and treatment are discussed.

Adolescent↗