Nitrous oxide: a serious look at laughing gas.
The purpose of this manuscript is to review the history, indications, and contraindications of nitrous oxide/oxygen as a conscious sedative agent. Included is a discussion of its addictive potential and the implications of its utilization with individuals who are recovering from addictive diseases. Additional discussion is devoted to the myeloneuropathies resulting from sustained "recreational" use. Particular attention is directed to dental personnel, the population with the greatest risk for addiction.