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Biomedical subjects

V A Konyshev

Publications and source records attributed to V A Konyshev.

At least 19 recordsLinked to original sources
PubMed1985

[Arachidonic acid metabolites, leukotrienes--mediators of hypersensitivity and inflammation].

A problem of leukotrienes--metabolites of arachidonic acid is reviewed in immunological aspects. Their nomenclature is given; basic pathways of biosynthesis, transformation and mode of leukotriens participation in hypersensitivity and inflammatory reactions are considered. The possibility of application of leukotrienes antagonists and inhibitors of their formation for allergic diseases treatment is discussed.

Animals↗
PubMed1983

[Genetic code: codon bases--the symbols of amino acid synthesis and catabolism pathways].

The correlations between genetic codes of amino acids and pathways of synthesis and catabolism of carbon backbone of amino acids are considered. Codes of amino acids which are synthesized from oxoacids of glycolysis, the Krebs cycle and glyoxalic cycle via transamination without any additional chemical reactions, are initiated with guanine (alanine, glutamic and aspartic acids, glycine). Codons of amino acids which are formed on the branches of glycolysis at the level of compounds with three carbon atoms, begin with uracil (phenylalanine, serine, leucine, tyrosine, cysteine, tryptophan). Codes of amino acids formed from aspartate begin with adenine (methionine, isoleucine, threonine, asparagine, lysine, serine), while those of the amino acids formed from the compounds with five carbon atoms (glutamic acid and phosphoribosyl pyrophosphate) begin with cytosine (arginine, proline, glutamine, histidine). The second letter of codons is linked to catabolic pathways of amino acids: most of amino acids entering glycolysis and the Krebs cycle through even-numbered carbon compounds, have adenine and uracil at the second position of codes (A-U type); most of amino acids entering the glycolysis and the Krebs cycle via odd-numbered carbon compounds, have codons with guanine and cytidine at the second position (G-C type). The usage of purine and pyrimidine as the third letter of weak codones in most of amino acids is linked to the enthropy of amino acid formation. A hypothesis claiming that the linear genetic code was assembled from the purine and pyrimidine derivatives which have acted as participants of primitive control of amino acid synthesis and catabolism, is suggested.

Amino Acid Sequence↗
PubMed1980

[Age dependence of the median duration of the mitotic cycle and the time for duplication of the hepatocyte number in ontogeny and in liver regeneration].

A mathematical intepretation is given for the published data on the kinetics of proliferation of the hepatocytes during ontogenesis and liver regeneration. The equations were obtained which described the age dependence of the mitotic cycle duration, the time of the cell number was found prior to the sexual maturation of the animals; the minimal and regeneration; a "break" of the curve describing the change of the time of duplication of the cell number was found prior to the sexual maturation of the animals; the minimal duration of the mitotic cycle and the time of duplication of the cell number during ontogenesis and liver regeneration was estimated; the age of animals was established at which the mitotic cycle of hepatocytes had the same duration as at the definite stage of liver regeneration.

Aging↗
PubMedDate not supplied

[The dynamic localization of a dipole source of the alpha rhythm in the human brain].

In 11 subjects the dynamic localization (with 2-ms step) of the equivalent current dipole of alpha rhythm during travelling alpha waves was studied using one-dipole 3-layered spherical head model and MRI. The dipole was localized in the occipital cortex and during the development of a single alpha wave it shifted in one or another direction while dipole's moment revealed fan-like rotation mainly in sagittal and horizontal planes. The results obtained indicate changing localization of the alpha-rhythm source in the region corresponding to striate cortex. They seem to prove scanning hypothesis that is still under discussion.

Adult↗