[Pathogenetic basis for ozone therapy as a modality to treat vibration disease (literature review)].
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Biomedical subjects
Publications and source records attributed to V A Kir'iakov.
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Having analyzed literature data and results of their own research, the authors describe early alterations on the cellular and molecular levels of the organism in exposure to local and general vibration. Those include changes in oxidative metabolism, immune shifts, lesions of cell membranes, deterioration of blood rheology, lesions of muscular and connecting tissues, disturbances of mineral exchange. The paper suggests a complex of laboratory tests for early detection of prepathological conditions of the organism in exposure to vibration. It includes measurement of certain parameters, such as the serum levels of vitamin E, malonic dialdehyde, immunoglobulins IgA, IgM, IgG, circulating immune complexes as well as assessment of antioxidative activity, peroxide erythrocyte hemolysis, spontaneous and ADF-induced thrombocyte aggregation, measurement of erythrocyte diameter and volume, creatinine and oxiproline urine concentration, myoglobine blood level and copper serum level. The above parameters are of sufficiently high diagnostic sensitivity and reflect the main aspects of vibratory pathology pathogenesis.
Miners of basic professions employed in contemporary metal mining industry are exposed to a range of industrial factors, such as vibration, noise, dustiness, and unfavorable microclimate. Long-term exposure to these factors is hazardous to their health, which is manifested by elevated general and occupational morbidity and a higher rate of biological aging. This is most typical of Far North miners, who are exposed to the combination of the industrial factors and extremal climate and geographic conditions. Research into the health status of miners engaged to underground works and open excavations in regions with contrasting climate and geographic conditions, allowed determination of main industrial risk factors (vibration and noise), leading occupational diseases and groups of high risk of their development (according to the occupation and the length of service). The study found high risk of cardivascular diseases as well as pathology of the musculoskeletal system, which was highest in miners in Norilsk region.
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The authors report a case of low spine vascular insufficiency. The clinical neurological syndrome resulted from compression of the accessory radiculomedullary artery by a dystrophic disk in a female patient with lumbar osteochondrosis. NMR tomography registered specific changes in the intervertebral disks and dural space which is decisive for differential diagnosis with similar symptoms of other affections.
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The authors provide the results of clinicoelectromyographic and immunomicrobiological examinations of 29 patients suffering from myelopolyradiculitis. The patients underwent intraspinal laser therapy, a new treatment modality. The method was demonstrated to be highly effective. The time required for the recovery of motor and sensual disorders as well as the time of staying at hospital could be 2 to 2.5 times as reduced. This enables recommending the method for introduction into practical neurology.
The authors provide the results of radiological examinations of cerebral circulation in 215 patients aged 16 to 67 years with different periods of cervical osteochondrosis. The intensity of hemispheric hemocirculation derangement depends on the stage of osteochondrosis. At the same time cerebral circulation disorders running their course by the type of transitory disturbances are not specific for the given group of patients and can also be seen in patients suffering from other diseases of the brain.
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The authors describe a case of Ollier's syndrome which developed in a 31-year-old female patient. The patient manifested hypertrophy of osseous and soft tissues, deformity of the dorsum sellae and of the walls of the cavernous sinus and siphon of the internal carotid artery. In the clinical picture of the disease, one could see symptoms of the impairment of pairs III and VI of the craniocerebral nerves, pains due to the irritation of the first branch of nerve V.
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The paper describes a clinical observation made in a 51-year old patient with brain cysticercosis. The onset of the disease resulted from symptoms of diencephalic damage (altered blood pressure, subfebrility, drowsiness, hormonal abnormalities). Following 4 hours paroxysmal phenomena appeared. The diagnosis was established by using skull X-ray study and computed tomography.
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As many as 33 children operated on for congenital meningocele of the inferior parts of the spine were subjected to clinicoelectromyographic studies. Alterations seen in the amplitude of the maximum M-response serve as one of the objective indicators of the degree of neuromuscular lesions. According to the magnitude of that amplitude, the patients were distributed into 4 groups: I /0 mV/, group II /0-1 mV/, group III /1-6 mV/, group IV /more than 6 mV/. The F wave reflecting the status of antidromic excitability of the spinal motoneurons is only recordable in groups III and IV of the patients (65%), with the magnitude of the maximum M-response being over I mV. H-reflex, as an indicator of reflex excitability of the motoneurons, is the most labile electromyographic parameter which is only recordable in some patients belonging to group IV, constituting 12% of the total number of the examined patients.