Search PubMed⌕ Search

Biomedical subjects

V A Iakovlev

Publications and source records attributed to V A Iakovlev.

At least 37 records · Page 2Linked to original sources
PubMed1997

[The place of fasting therapy in the treatment of hypertension].

The study of changes in cardiovascular system and its regulation mechanisms occurring in 150 hypertension stage II patients on fasting diet has established the following phenomena: inhibition of the basic metabolism and generation of energy leading to low activity of central mechanisms regulating hemodynamics and reduced adaptability of such mechanisms, weakening of sympathetic influences on the myocardium and smooth muscle cells of the resistant vessels, their reduced contractility as a result of decreased calcium concentration and energy production in the cells.

Adult↗
PubMed1996

[Chronostructure of ectopic heart activity in the acute phase of myocardial infarction].

7-day monitoring of cardiac rhythm has been conducted in 42 patients with myocardial infarction (MI) and 15 patients with chronic ischemic heart disease. Hour-by-hour analysis of extrasystole demonstrates that probability of ventricular arrhythmia is maximal in transmural MI, the first 3 days of acute MI are most arrhythmogenic. Follow-up of ventricular ectopic activity (VEA) showed the latter to significantly enhance early in the morning, afternoon and on the first 5 days after midnight. In unpenetrating MI, VEA intensifies in the morning, afternoon and postmidnight hoars. Atrial ectopic activity (AEA) in transmural MI enhances early in the morning, afternoon and at night (on the first 3 days). AEA in unpenetrating MI is more intensive late in the morning and afternoon.

Acute Disease↗
PubMed1994

[The mechanisms of the therapeutic action and the basis for the frequency of performing sessions of ultraviolet blood irradiation in treating acute pneumonia. 1].

Mechanisms of therapeutic action of UV blood irradiation and optimal irradiation scheduling were studied in the course of UV-irradiated blood transfusions capable of correcting lipid peroxidation (LPO) and antioxidant system (AOS) in acute pneumonia (AP) patients. Single and multiple measurements of LPO and AOS parameters (malonic dialdehyde, diene conjugates, red cell resistance to peroxide hemolysis, catalase, superoxide dismutase, cerulloplasmin, plasma total estrogens, progesterone and testosterone) were made in 10 young males with moderate AP and 20 healthy controls. UV blood irradiation in AP is shown to be pathogenetically validated. It works via effective stabilization of LPO as a result of early adequate stimulation of endogenic AOS. Positive changes were also induced in the system of hormonal regulation. It is suggested that hyperestrogenemia plays a compensatory role in AP pathogenesis.

Acute Disease↗
PubMed1992

[The metabolism of eicosanoids, glucocorticoids and cyclic nucleotides in young people with acute pneumonia].

An investigation into the pathogenesis of acute pneumonia in 37 young men made it possible to ascertain the role of arachidonic acid metabolites and hormonal regulation in the pathogenesis of the inflammatory reaction in acute bacterial pneumonia. At the initial stage of inflammation, invasion of the infectious agent leads to phagocytosis activation, stimulates the output of immunoglobulins belonging to different classes, which, binding antigens, form immune complexes influencing the output of biologically active substances. This is accompanied by the destruction of pulmonary tissue, release of lipid peroxidation radicals and proteinases, by the enhancement of arachidonic acid degradation under the destructive action on the membranes of phospholipase A2 cells to form prostaglandins participating in the changes in the tone of bronchi, pulmonary vessels and affecting blood coagulation. Activation of the hypophyseo-adrenal system leads to the attenuation of the effects produced by biologically active substances and exerts varying actions in the acute and convalescence periods. The data obtained stress an important role played by metabolic functions of the lungs in the integrative connections of all the systems of the body maintaining homeostasis in pneumonia and the main function of the lungs, namely ventilation.

Acute Disease↗
PubMed1991

[Treatment of pulmonary thromboembolism with small doses of streptokinase combined with heparin, nitroglycerin, and prednisolone].

The efficiency of method worked out by the authors for pulmonary thromboembolism management surpasses the existing routine schemes of treatment by standard doses of streptokinase. The opportune application of this method gives positive results in considerable percentage of cases, i.e. in massive and submassive thromboembolism with acute or recidivating course.

Adult↗
PubMed1991

[Ultraviolet irradiation of autologous blood in the complex treatment of patients with diabetes mellitus].

A single reinfusion of UV-irradiated autologous blood was performed in 76 patients with non-insulin-dependent (NID) and insulin-dependent (ID) diabetes mellitus. Lipid peroxidation (LPO), activity of glycolysis and pentose cycle principal enzymes, red cell cyclic nucleotides, hormones concentrations, glucose utilization were investigated. It is shown that general physiological action of UV radiation is primarily due to LPO stimulation responsible for changes in cell membrane properties. This action may vary with baseline LPO characteristics. UV radiation is valid in combined therapy of NID diabetes mellitus as it activates intracellular metabolism, reduces concentration of ++contra-insular hormones, improves tissue utilization of glucose. ID diabetes mellitus is contraindication for UV radiation use as additional stimulation of initially high LPO entails inhibition of activity of intracellular enzymatic systems participating in glucose metabolism, leads to low production of endogenous insulin.

Adult↗
PubMed1991

[Exogenous and endogenous risk factors in the development of nonspecific lung diseases in young people].

An organized community numbering 900 normal subjects aged 18 to 19 years were examined. Acute pneumonia was encountered in 15% of persons of the group under study per year. To identify persons with premorbid condition of nonspecific pulmonary diseases, anamnestic screening and outpatient examinations (microbiological and immunologic studies) were performed. As a result, the group constituted by subjects at risk for disease accounted for 18.6%, whereas S. pneumoniae was found in 44.9%. The immunologic findings were compared to the data obtained in the anamnestic screening. It was inferred that certain anamnestic signs correlated with the immune status. The leading factor in the formation of the premorbid condition lies in integral shifts in the immunologic system during adaptation. It follows from the data obtained that persons with risk factors need immune correction.

Adolescent↗
PubMed1990

[Diseases of the cardiovascular system and the function of the endocrine glands in veterans of Soviet Antarctic expeditions].

The authors examined 58 men who had repeatedly participated in the Antarctic expeditions. In addition to a profound study of the cardiovascular system, the insulin tolerance test (0.1 U/kg simple insulin injected by intravenous drip for 90 minutes) was made, permitting the degree of tissue insulin resistance to be quantitatively estimated with measurements of the content of cyclic nucleotides in blood leukocytes and of immunoreactive insulin, C-peptide and counterinsular hormones in the blood before and after the functional test. It was established that with the increase of the number of Antarctic winterings tissue insulin resistance naturally grows regardless of the age of the examinees, manifesting itself in an increase of basal insulinemia, the content of cyclic adenosine monophosphate in blood leukocytes, appreciable increment of insulinemia after infusion of exogenous insulin. Analogous changes were detected in polar researchers suffering from coronary disease, essential hypertension irrespective of the number of winterings. It is concluded that the rise of tissue insulin resistance occurring under the influence of multiple exposures to natural and social factors of high latitudes is a predisposing factor of the formation of cardiovascular pathology.

Adaptation, Physiological↗