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Biomedical subjects

V A Fomina

Publications and source records attributed to V A Fomina.

13 recordsLinked to original sources
PubMedDate not supplied

[The peroxisomes of eosinophilic leukocytes].

Functional properties of peroxidase-containing granules (peroxidasosomes) of eosinophiles are discussed. Findings are reported on the activities of peroxidase systems and of non-enzymic cationic proteins which occur in the eosinophilic peroxidasosomes in normal state and in various pathological states as well as their antimicrobial and antiparasitic activities.

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PubMedDate not supplied

[The antimicrobial proteins and peptides of neutrophilic leukocytes].

Findings suggesting a vast variety of non-enzymic cationic proteins and peptides in human and animal leucocytes are reported. These cationic proteins and peptides demonstrate their antimicrobial and cytotoxic properties due to their detergent characteristics and their capacity to change the permeability of cellular wall and membrane by electrostatic interactions. Information on their homology with some serine proteases is presented.

Animals↗
PubMedDate not supplied

Electron cytochemistry of peroxidase activity in neutrophils of the bone marrow of the frog Rana temporaria.

The bone marrow of the frog was studied during the spring and winter periods. During the winter period, one type of large granules in the neutrophils of the frog proved to be peroxidase-positive. The remaining, smaller granules are peroxidase-negative. In the spring, immature and mature neutrophils are encountered in the frog. The mature neutrophils of the frog in the spring and winter periods are analogous. The immature neutrophils contain peroxidase activity in the perinuclear space, the endoplasmic reticulum and some of the granules. Some of the peroxidase-containing granules are directly associated with the canals of the endoplasmic reticulum. In the immature neutrophils, during the formation of the peroxidase-containing granules, peroxidase-negative granules smaller in size are already present in the cytoplasm. Thus, the sequence of granule formation usual for mammals is apparently not observed in the neutrophils of certain amphibia. "Annular" mitochondria, encompassing part of the cytoplasm were detected in the neutrophils. These apparently represent a section through a spherical mitochondrion enveloping and isolating a certain zone of the cell. It is proposed that the mitochondria in this way, differing from the lysosomal mode, participate in the catabolism of the cytoplasm.

Animals↗
PubMedDate not supplied

[Antixenosomes].

Data on the existence of organelles, binding and inactivating xenobiotics on the subcellular level in animal and plant cells is presented. The morphology of these organelles both the enzymatic constituents and their expected physiological function in immunological homeostasis are discussed. The data presented suggests that the previously discussed organelles such as chloragosomes, cadmosomes, metallogranules, keratinosomes, lamellar and myeloid bodies of animal and plant cells belong to the united class of organelles--antixenosomes which segregate, bind and inactivate xenobiotics protecting both cells and the entire organism from their harmful effect.

Animals↗