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Biomedical subjects

V A Filin

Publications and source records attributed to V A Filin.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

A randomized comparison of triple therapy Helicobacter pylori eradication regimens in children with peptic ulcers.

An open, randomized trial was performed to compare the efficacy of three Helicobacter pylori eradication regimens in children with peptic ulcer disease. A total of 106 children (5 - 15 years) were treated for 1 week with metronidazole, 30 - 40 mg/kg per day depending on age, amoxycillin, 750 mg/day, and one of three anti-secretory agents: proprietary omeprazole, 20 - 40 mg/day depending on age; generic omeprazole, 20 - 40 mg/day; or ranitidine, 150 mg twice daily. The H. pylori eradication rate was significantly higher in patients receiving proprietary omeprazole (88.9%) than in those receiving generic omeprazole (80.0%) or ranitidine (74.3%), and this was associated with a trend towards faster ulcer healing. It is concluded that triple therapy consisting of an anti-secretory agent and two antimicrobials produces effective eradication of H. pylori and ulcer healing in children with peptic ulcer disease, and that proprietary omeprazole is more effective than both ranitidine and the generic formulation used in this study.

Adolescent↗
PubMedDate not supplied

[The effect of illumination on involuntary eye saccades].

A study was made of the influence of sudden illumination micromovements of the eyes. Sudden contour illumination of the eye by a 15 degrees field with a crossing in the centre and a brightness of 100 nit reduced the amplitude of involuntary saccades and their frequency. The effect was particularly distinct with preliminary recording of the eye micromovement in complete darkness without a fixation point. In the case of fixation of a stationary point with one eye and of illumination of the other, the effect was also manifest, but it was less pronounced. During illumination of the eye with diffused light (through spectacles with frosted glasses) the effect of diminution of the saccade amplitude was smaller, though the brightness remained unchanged. A decrease in the saccade amplitude was practically not observed when the point was fixed at diffuse illumination. It has also been shown that with greater brightness of the fixation point (0.3; 25; 92 and 1000 nit), the amplitude and frequency of involuntary saccades diminish. The results attest that in choosing the conditions of work of the saccadic system two factors should be taken into consideration: the presence of the contours of the visible object and its brightness, the latter by itself having a lesser effect than the former.

Eye Movements↗