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Biomedical subjects

V A Evseev

Publications and source records attributed to V A Evseev.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses.

The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.

Animals↗
PubMedDate not supplied

[The effect of active immunization with a conjugate of dopamine and bovine serum albumin on the development of an experimental MPTP-induced depressive syndrome and on the monoamine metabolism in the brain of rats].

Active immunization with dopamine conjugated with bovine serum albumin (DA-BSA) or BSA with complete Freund's adjuvant (CFA) partly suppressed the development of the MPTP-induced depressive syndrome in rats preventing the appearance of "behavioral despair" symptoms: increase in immobility time and higher index of depression in forced-swim test. In DA-BSA-immunized rats the content of DOPA, DA, HVA, NA, and 5-HN in caudate putamen and that of NA in the frontal cortex was increased, while in BSA-immunized rats the content of 5-HT in both brain areas and that of DOPAC in the frontal cortex was decreased both in rats with reduced depressive syndrome and in saline control as compared with intact animals a day after the last drug injection. In DA-BSA-immunized rats with reduced depressive syndrome the increase in DA and 5-HT content in caudate putamen was less expressed and DOPAC content was lower than in saline control. In BSA-immunized depressive rats DA content in the frontal cortex was also reduced as compared to control.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMedDate not supplied

[Effect of dopamine antibodies on neuropathic pain syndrome in rats].

Dopaminergic brain system plays an important role in regulation of pain sensitivity. However, the data on participation of antidopamine antibodies in the development of neurogenic pain are absent. This work was aimed at the study of the role of antidopamine antibodies in the development of pain syndrome induced by the injury of nn. ischiadic and saphenous in rats. It was shown that after the nerve injury, the behavioral reaction such as autotomy (self-injury) appeared as a feature of the experimental neuropathic pain syndrome. It was originally established that the development of neuropathic pain syndrome induced by the injury of peripheral nerves was accompanied by induction of dopamine autoantibodies. It was also shown that immunization of the animals with conjugated dopamine-protein autigen resulted in aninerease of autidopamine antibody level and an amplification of the experimental neuropathic pain syndrome, i.e., decrease in the latency of the first autotomy, increase in expression of autotomies, and increase in the number of animals with late autotomies.

Animals↗
PubMedDate not supplied

[Modulation of behavior of mice of different genotypes by serotonin antibodies].

The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour.

Animals↗
PubMedDate not supplied

[Dopamine antibodies as neuromodulators of behavioral reactions in mice of different genotypes].

A possibility of the long-term modification of inborn behavioral features of different mice genotypes (C57B1/6 and BALB/c) by active immunization with dopamine-bovine serum albumin conjugate was investigated. Significant interstrain differences were found in the effects of dopamine antibodies on the open-field behavior and the content of neurotransmitters in the brain cortex and striatum. It was shown that the active immunization of mice to dopamine produces an increase in the functional activity of brain dopamine receptors. The extent, to which this increase is pronounced, is genotype-dependent.

Animals↗
PubMedDate not supplied

[Use of substance P fragments in experimental treatment of alcoholism].

Experiments on unbred male mice demonstrated qualitative differences in the pharmacological effect of substance P fragments (P1-4 and P5-11) injected intraperitoneally in a dose of 250 mcg/kg. Fragments P1-4 and P1-4 dodecylamide on the one hand, had a positive effect on the level of motivation which was displayed by lesser consumption of alcohol by the animals, and, on the other, possessed immunocorrective properties manifested by restoration of macrophage phagocytic activity and immune response to sheep erythrocytes, which were impaired by chronic alcoholic intoxication. Fragment P5-11 had no effect on alcoholic motivation and produced a directly contrary action on the immune system, it inhibited the formation of antibody-forming cells.

Alcoholism↗
PubMedDate not supplied

[Effect of induction of antibodies to serotonin on alcohol consumption and the status of the brain mediator system in rats with various degrees of alcohol motivation].

Active immunization with serotonin-protein conjugate in rat experiments increased ethanol preference in animals with weak alcoholic motivation but reduced it in those with a high alcohol consumption. The level of antibodies to serotonin in blood was higher in alcohol-preferring rats than in water-preferring animals. The reduction of alcohol intake correlated with reduction of the level of 5-OH-indoleacetic acid in the animals' hypothalamus. It is assumed that the contrary effect of immunization with serotonin-protein conjugate on the alcoholic behavior of animals with a different initial level of alcoholic motivation is linked with the difference in their neurochemical organization.

Alcohol Drinking↗