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Biomedical subjects

V A Baturin

Publications and source records attributed to V A Baturin.

At least 19 recordsLinked to original sources
PubMed2004

The effects of lesions to the striatum on the function of the hypothalamo-hypophyseal-adrenal system in adrenalectomized rats.

Experiments on white rats were performed to study the effects of bilateral lesioning of the striatum on activation of the hypothalamo-hypophyseal-adrenal system (HHAS) after unilateral adrenalectomy. These studies showed that increases in the weight of the surviving adrenal gland were smaller in striatectomized rats than in controls. There was a significant decrease in corticosteroid production by the intact gland. These changes were most marked after destruction of the dorsal parts of the nucleus. These data provide evidence for involvement of the striatum in controlling HHAS activity via a feedback mechanism.

11-Hydroxycorticosteroids↗
PubMed2002

Investigations of thermoluminescence dosimetry in the Techa river flood plain: analysis of the new results.

The Techa river region was highly contaminated due to radioactive releases from a nuclear production facility in the period from 1949 to 1956. The inhabitants of the upper Techa river settlements received significant doses of external radiation. The majority of the houses in the upper Techa river villages were demolished after the evacuation of the population in 1956. Only three buildings (red-brick construction) in the former village of Metlino can still be used for thermoluminescence (TL) investigations in an external dose reconstruction study. The radiation source configuration changed in 1956 after an artificial reservoir was created next to Metlinsky pond. Preliminary TL studies showed good properties of the bricks that were sampled from the buildings. This paper presents an analysis of new results of TL investigations obtained on the samples collected from different walls of the buildings. The highest dose values in the range 1-4 Gy were found in bricks collected from the walls of building exposed to the artificial reservoir (Reservoir-10) and values of 1-1.5 Gy were found next to the Metlinsky pond shoreline. The measurements of the radiation source geometry were carried out simultaneously with the dose rates, radionuclide concentration in water and bottom sediments near the wall facing the old river bed. The measurements allow a validation of models used in the current Techa River Dosimetry System (TRDS-2000) to estimate external doses of the former inhabitants of the upper Techa riverside. In particular, the results can be applied for a more correct description of the source geometry in the settlement.

Fresh Water↗
PubMed2002

[Effect of striatum destruction on the hypothalamo-pituitary-adrenal axis function in adrenalectomized rats].

The influence of the bilateral striatectomy on activation of the hypothalamus-pituitary-adrenal axis after unilateral adrenalectomy was investigated. Increasing of the intact adrenal gland's mass in striatectomized rats was less than in the control group. It was combined with decreasing of the production of corticosteroids by intact gland. Such disturbances were more obvious in rats with destruction of the dorsal striatum than the ventral one. These facts suggest the striatum participation, its dorsal zone in particular, in the processes of regulation of the hypothalamus-pituitary-adrenal axis.

11-Hydroxycorticosteroids↗
PubMed2000

Radioecological impacts of the Techa River contamination.

During the years 1949-1952, the Mayak Production Association (MAYAK), which was processing weapons-grade plutonium, was discharging radioactive wastes into the Techa River. As a result, all components of the river system (water, bottom soils, and flood plains) were exposed to massive radioactive contamination. The protective measures taken in the 1950's resulted in the improvement of the radioecological conditions in the Techa River. After 1952, the radioecological conditions in the area were mostly determined by the long-lived radionuclides 9OSr and 137Cs. This article focuses on the dependencies governing the migration of radionuclides along the vertical and horizontal planes in different components of the river system over a 40-y period. Until the 1990's, a decrease in 90Sr and 137Cs contents was noted in environmental samples and foodstuffs produced in riverside villages. In the subsequent years, the radioecological situation on the Techa stabilized. The sources of the current contamination of the river are represented by the runoffs from by-pass canals and swampy upper reaches.

Cesium Radioisotopes↗
PubMed1991

[Reproduction of the minute time interval in depression in patients with schizophrenia and manic-depressive psychosis].

As many as 21 patients with endogenous depressions were examined by the "individual minute" method 3 times a day during hospital treatment with tricyclic antidepressants and neuroleptics. MDP patients had an anxious type of depressive affect, those with schizophrenia had anxious and uneasy types. In the anxious type of depressive affect, the "individual minute" was considerably shortened at the study onset; in the uneasy type, it was similar to normal. In patients with MDP, normalization of the "individual minute" was seen during reduction of depression (at r = -0.63). In schizophrenic patients, the short "individual minute" underwent little changes in the course of the clinical state improvement and depression was refractory to the treatment. The data obtained may be of importance in studying chronobiology of endogenous depressions.

Adult↗
PubMed1991

[Normalizing effects of antidepressive imipramine on reorganization of circadian motility in light period shift in pinealectomized rats].

A change in the reorganization of the circadian motor activity following a 10-hour shift in the photo period was observed in the pinealectomized rats. After antidepressant imipramine (10 mg/kg, 14 days), such reorganization of the circadian rhythm was also changed in the intact animals. At the same time imipramine eliminated the disruption in the resynchronization of the daily motility following pinealectomy.

Animals↗
PubMed1990

Chronic administration of pineal peptides change the circadian locomotor activity and time-course of forced swimming in rats.

After chronic administration of epithalamin (a pineal peptide drug), an increase in the amplitude and shifts in the acrophase of rat's circadian locomotor activity to late hours were observed. These results were obtained only in rats with low initial amplitude of their circadian rhythm. Epithalamin also changed the time-course of forced swimming and decreased the rhythmic index of depression. These observations suggest that the pineal gland of the rat, via its peptides, may prevent the development of depressive-like events.

Activity Cycles↗
PubMed1990

[The effect of epiphyseal peptides on the dynamics of the circadian and minute motor biorhythms in rats].

Chronic administration of pineal peptide drug epitalamin (0.5 mg/kg for 5 to 10 days) modulated the rat circadian locomotor activity: the animals with low circadian rhythm amplitude were activated whereas the rats with an obvious circadian fluctuations were depressed. The epitalamine obviously decreased an apomorphine-induced stereotype at 13.00 hours rather than at 19.00 hours. The rhythmicity of the stereotype changed in different ways depending on the rat individual susceptibility. The drug decreased the number of 1-3-minute waves if it had been high initially, and increased it if slow fluctuations had dominated. Pineal peptides seem to participate in the maintenance of homeostatic equilibrium at the expense of stabilizing different periods of rhythmical processes.

Animals↗
PubMed1989

[Characteristics of the combined action of melatonin and imizin on the structure of forced swimming and the circadian rhythm].

Acute administration of melatonin (10 mg/kg) produced a depressed effect on the mice behavior. But it's injection after chronic imipramine (10 mg/kg/day, 2 weeks) potentiated antidepressant ability and shortened the duration of immobility in the structure of swimming. In rats, which had a high amplitude of circadian rest-activity rhythm, melatonin produced imipramine effect on circadian mobility, but potentiated antidepressant action in animals with low initial level of locomotor activity.

Animals↗
PubMed1988

[Effect of destruction of the hypothalamic suprachiasmatic nuclei on the dynamics of swimming and haloperidol-induced catalepsy in rats].

After bilateral destruction of suprachiasmatic nuclei, with adjacent hypothalamic structures remaining intact, the number of rest-activity cycles during forced swimming as well as short waves with 2-4-min periodicity in haloperidol catalepsy, were increased in rats. The circadian rhythm became disorganized. Suprachiasmatic nuclei seem to be able to delay and synchronize the fluctuations with short periods in motor activity.

Animals↗
PubMed1982

Effect of haloperidol and chlorpromazine on reversal learning of normal and striatectomized rats in a Y-maze.

Haloperidol (0.05-0.1 mg/kg) and chlorpromazine (0.5-1.0 mg/kg) improved reversal learning avoidance responses in a Y-maze, decreased intersessional fluctuations of errors and decreased the number of spontaneous exits from a correctly selected chamber. After bilateral lesions of the striatum this effect disappeared. Brain lesions also attenuated the ability of neuroleptics to suppress amphetamine-induced stereotypy and and accompanying defects in avoidance responses. The improvement of avoidance behavior by neuroleptics may be related to the reduction of spatial preference caused by functional asymmetry between the bilateral nigro-striatal systems.

Amphetamine↗
PubMed1980

[Effect of haloperidol on fenamin stereotypy].

Bilateral electrolytic lesion of the striatum disturbs the ability of haloperidol (0.1 mg/kg) to normalize the avoidance behaviour of rats given amphetamine (5 mg/kg). Low doses of the neuroleptic (0.03--0.06 mg/kg) potentiate the inhibition of amphetamine-induced stereotypy that occurs after discontinuation of repeated electric stimulation of the cat caudate nucleus. Participation of the striate mechanisms in the realization of specific psychotropic acitivity of neuroleptics is suggested.

Amphetamine↗
PubMed1977

[Vectorgraphic assessment of the influence of different psychic stimulators on the avoidance behavior of rats].

The authors assessed the influence of psychostimulants on relearning of rats of the avoidance direction in a Y-maze. The effects were analyzed vectorographically with the absolute and relative values by the main response indices. The behaviour curve of the group of animals was drawn in both cases. Sydnocarb (20 mg/kg) produced the most optimal effect; in difference from caffeine (25 mg/kg) and d,1-amphetamine (0.5 mg/kg) it not only stimulated the active avoidance, but also improved the animal relearning. An increase of the sydnocarb dose to 50 mg/kg failed to disturb rat behaviour, whereas caffeine (50 mg/kg), and particularly d, 1-amphetamine (5 mg/kg) did cause such disturbance. The behaviour curve of the latter coursed beyond the level of the initial level and was characterized by a marked aggravation of passive avoidance.

Amphetamine↗