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Biomedical subjects

V A Ado

Publications and source records attributed to V A Ado.

At least 19 recordsLinked to original sources
PubMed1992

[Delayed hypersensitivity to house dust-storage mites Thyrophagus putrescentiae in experimental allergic dermatoses].

House dust mites and storage mites proved to be one of the main allergens causing hypersensitivity in atopic dermatitis in allergic patients. The authors reproduced experimental allergic dermatosis on the model of delayed type hypersensitivity in guinea pigs, caused by sensitization to the allergen from the mite's bodies Tyrophagus putrescentiae--species having wide distribution in the country. The results characteristic for T-cell type hypersensitivity have been obtained: delayed positive skin tests after 24 hours, typical histomorphological picture (strong allergic alteration, epidermis desquamation, vasculitis, dermis T-cell infiltration and spongiosis--Waksman's syndrome). It is concluded that side by side with humoral IgE-mediated reaction there is strong delayed T-cell hypersensitivity to the storage mites Tyrophagus putrescentiae.

Animals↗
PubMed1982

[Urticaria].

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Humans↗
PubMed1981

[Allergy].

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Allergens↗
PubMed1980

[Toxic, anaphylactoid, and sensitizing properties of mercaptoquinolinates, metals of the 8th and 3d group].

A study was made of sensitizing, toxic and anaphylactoid action of eitht compounds of metals belonging to groups VIII and III of the periodic system. It was established that the activity depends on the nature of the central atom in the electronic structure of a complex salt ligand. The mechanism of histamine release was shown to be similar to that of specific antigen and to be related to preservation of the respiratory processes, of the microtubular and cell cyclic nucleotide systems. The sensitizing action of the compounds was shown by the reactions of the immediate and delayed types. Moreover, its realization did not require the presence of high molecular carriers, thus indicating that the latter is formed in the body.

Allergens↗
PubMed1980

[Comparative study of the toxic, anaphylactoid, and sensitizing properties of 5-sulfo-8-mercaptoquinolinates of metals of the 8th and 3d groups of the periodic table].

Pronounced allergizing action of the compounds of group VIII metals of the periodic system, observed in occupational pathology and commencement of their wide clinical application as cancerostatic agents require a comprehensive study of the properties of these substances. Anaphylactoid, toxic and genuine sensitizing action of 5-sulfo-8-mercapto-quinolinates of group YIII metals and those of group III metals having similar properties was studied and compared with reference to 8 compounds. It was shown that histamine liberation from mast cells induced by these substances as well as inhibition of the respiration of mast cells depend on the central atom and electronic structure of the ligand. The mechanism of histamine liberation observed was similar to that of specific antigen and was related to the preservation of the respiratory processes, the system of microtubules and cell cyclic nucleotides. The compounds tested were also capable of sensitizing the animal in intracutaneous injection of the substance without exogenous carrier. Sensitization developed according to the reaction of both the immediate and delayed types.

Allergens↗
PubMed1980

[Experimental study of the allergenic activity of the pollen of Cyclachena xanthifolia].

Comparative studies of Cyclachena xantifolia and Ambrosia artemisifolia have been carried out by light, scanning and electron microscopy. Cyclachena xantifolia allergic properties have been examined in guinea-pigs. Senstization of animals has caused the increased number of immunocompetent cells in regional and distant lymph nodes, the appearance of high titers of reagin-like antibodies capable of fixing in the skin. Injection of the proper dose of allergen has resulted in the development of anaphylactic shock of different severity. The role of Cyclachena xantifolia in the etiology of pollinoses has been ascertained.

Allergens↗
PubMed1979

[Drug allergy].

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Dermatitis, Contact↗