We should dampen our enthusiasm for computer-aided detection in colonoscopy: at least for now.
Explore the source record for details and available documents.
Editorial↗
Biomedical subjects
Uri Ladabaum
Publications and source records attributed to Uri Ladabaum.
Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer.
Familial adenomatous polyposis (FAP) is a rare, hereditary syndrome that raises the risk of developing colorectal cancer (CRC). This disease model is well suited for studying the early stages of malignant transformation. Our spatial CODEX experiments reveal that, in contrast to normal mucosa, FAP mucosa, pre-cancer polyps and colorectal cancers exhibit substantial alterations in the cell type composition and tissue microenvironment. These early alterations include: an increase in the population of cancer-associated fibroblasts (CAFs), and the inhibition of tumor infiltrated lymphocytes and cell-adhesion protein by CAFs, the transformation of memory T cells into regulatory T cells, nuclear translocation of beta-catenin from the cell membrane, a decrease in the M1:M2 macrophage ratio, a notable increase in angiogenesis events. Our studies define the early stem cell, stromal, and immune steps of colorectal cancer and may benefit early detection, and therapeutic intervention.
Co-detection by Indexing (CODEX)↗