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Biomedical subjects

U Ziegler

Publications and source records attributed to U Ziegler.

49 records · Page 3Linked to original sources
PubMed1982

Morphological alterations in epithelial cells of the mouse gallbladder 30 hours after treatment with lithogenic diet.

Mice were fed a gallstone inducing diet. Thirty hours after treatment, distinct morphological alterations in the gallbladder epithelium occurred. The most striking effect was the short-term appearance of large cisternae, which emerge as a result of coalescence of dilated cavities of the rough endoplasmic reticulum. At the same time, an increased storage of small granular material was observed. These alterations did not appear after treatment lasting for less or more than thirty hours. The development started with an enlargement of the endoplasmic cavities, whereas the Golgi apparatus did not seem to undergo transformations; therefore, a transport stop of the secretory products of the epithelial cells must be located at the connection between both organelles. The formation of the endoplasmic cisternae seemed to be caused by a reversible block of the intracellular transport pathway of the secretion products.

Animals↗
PubMed1982

[Not Available].

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Balneology↗
PubMedDate not supplied

Effects of L-serine on neurons in vitro.

We have examined the influence of amino acids on chicken embryonic dorsal root ganglion (DRG) neurons in vitro and have found that serine has a marked impact on the morphology of the developing neurites. In cultures supplemented with L-serine (but not D-serine) at micromolar concentrations (10-200 microM), the length of the neurites was increased by up to 100% and they were seen to develop a more complex branching pattern. These effects of L-serine were found to be concentration-dependent and stereospecific and were observed on several different substrata such as laminin, Ng-CAM and axonin-1. Similar observations were also made in the case of embryonic retinal explants, while the addition of non-essential amino acids other than L-serine to DRG neurons was found to have no effect. We conclude that, although belonging to the group of non-essential amino acids and not a recognized neurotransmitter, L-serine is an important factor for the morphological differentiation of neurons in vitro.

Animals↗
PubMedDate not supplied

[Isokinetic muscle training with high motion speeds in the rehabilitation following surgical treatment of fresh anterior cruciate rupture].

In the course of a prospective investigation 17 patients with operatively treated acute anterior cruciate ligament ruptures received an isokinetic muscle training with high motion velocities in addition to the common physiotherapy from the 7th to the 19th week after operation. The comparative group consisted of 17 patients with operatively treated acute anterior cruciate ligament ruptures who were receiving the common physiotherapy only. The aim of the study was to improve both the postoperative dysbalance between agonists and antagonists and the active muscular stabilisation of the knee. The isokinetic muscle training was done with 150 degrees/s and a motion limit for flexion/extension of 0-20-90 degrees. The postoperative muscular dysbalance was improved significantly in the isokinetic group after 6 weeks of training compared to the control group. The flexion/extension ratio of the operated leg at 60 degrees/s came to 100% in the training group compared to 135% in the control group. This difference was even more apparent at 180 degrees/s with 100% in the isokinetic group compared to 160% in the control group and at 240 degrees/s with 110% compared to 200% respectively. The average maximum torque was 10 to 15% better with the training group as with the control group though there was no training of maximum force done explicitly. There was no effect on the postoperative anterior stability of the knee.

Adult↗
PubMedDate not supplied

Classical swine fever virus: clinical, virological, serological and hematological findings after infection of domestic pigs and wild boars with the field isolate "Spante" originating from wild boar.

A classical swine fever virus (CSFV) field isolate originating from wild boar was investigated on its virulence in domestic pigs and wild boar. Three weaner pigs and two wild boars (yearlings) were intranasally inoculated with the isolate "Spante" and tested for clinical, virological, hematological and serological findings until day 31 after infection (p. i.). One day p. i. the piglets were put in contact to three sentinel pigs. During a period of 31 d neither the domestic pigs nor the wild boars showed clinical signs specific for CSF. Two infected weaner pigs became transiently viraemic, transmitted CSFV in nasal secretions, showed a slight leukopenia and reacted serologically positive. The contact infection resulted in a viraemia in two sentinel piglets on day 30. Only one contact animal developed antibodies. None of the wild boars became viraemic, excreted CSFV in nasal secretions or developed antibodies. The CSFV isolate "Spante" represents a low virulent virus. Referring to a significant higher percentage of virologically positive tissue samples after nested PCR compared with the virus isolation, persistence of CSFV is discussed.

Animals↗
PubMedDate not supplied

Heart transplantation: hemodynamics over a five-year period.

Long-term hemodynamic evaluation after heart transplantation has rarely been reported. Fifty-seven heart transplant recipients (mean age, 42.1 years: range, 22 to 56 years) were investigated with annual cardiac catheterization. Mean follow-up was 2.2 years (range, 1 to 7 years). Years 1 through 5 were evaluated statistically. Hemodynamic variables did not change significantly during the 5-year period. Mean aortic pressure (105 +/- 16 to 115 +/- 17 mm Hg, minimum and maximum annual average value +/- SD of the 5-year period) and LVEDP (13 +/- 6 to 15 +/- 7 mm Hg) were slightly elevated. Borderline values were found for mean pulmonary artery pressure (18 +/- 4 to 21 +/- 5 mm Hg), systemic vascular resistance (1407 +/- 227 to 1487 +/- 409 dynes.sec.cm-5), pulmonary vascular resistance (86 +/- 42 to 118 +/- 66 dynes.sec.cm-5), and heart rate (85 +/- 17 to 95 +/- 14 beats/min). Mean right atrial pressure (5 +/- 2 to 8 +/- 4 mm Hg), cardiac index (2.8 +/- 0.6 to 3.5 +/- 1.1 L/min/m2), end-diastolic volume (111 +/- 37 to 137 +/- 35 ml) and ejection fraction (69% +/- 10% to 75% +/- 9%) were in the normal range. Pressure-volume loops for each year excluded the development of either restrictive or dilated cardiomyopathy with time. Contractility, as measured by imposing afterload stress, was normal in 12 of 14 representative patients. Prevalence of coronary abnormalities (circumscript coronary stenoses, diffuse vessel obliteration or dilated angiopathy) increased from 14.9% in the first to 66.7% in the fifth year. Of the patients, 93% received antihypertensive drugs.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

How successful is OKT3 rescue therapy for steroid-resistant acute rejection episodes after heart transplantation?

OKT3 is recommended as rescue therapy for cases of steroid-resistant, clinically persistant acute rejection episodes after heart transplantation. In this study we determined the efficacy of such treatment. One hundred thirty-two patients were included in this study. The postoperative immunosuppressive regimen consisted of triple-drug therapy and perioperative antithymocyte globulin. During a follow-up of 10 to 108 weeks (mean, 51 +/- 20 weeks) 281 treatment-requiring acute rejection episodes (International Society for Heart and Lung Transplantation > or = II) were observed. In 29 cases (10.3%) the grade of the acute rejection episodes was either unchanged after two series of intravenous steroid pulse therapy, was worsened after the first steroid course, or the patient experienced clinical deterioration as a result of the acute rejection episodes. These patients were considered to have steroid-resistant acute rejection episodes and received a 10-day rescue therapy with OKT3, followed by control endomyocardial biopsy. In 17 cases, control endomyocardial biopsy revealed normal myocardium (group I). In 10 cases acute rejection episodes remained unchanged (group II); twice a deterioration was found (group III). However, 12 of the 17 patients from group I experienced a rebound of the acute rejection episodes (International Society for Heart and Lung Transplantation > or = II) 1 to 3 weeks later. Side effects of OKT3 treatment were fever, chills, intestinal complications, hemodynamic response, convulsions, and viral infections.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗