Search PubMed⌕ Search

Biomedical subjects

U Werner

Publications and source records attributed to U Werner.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Therapy of organic psychosyndromes of cerebrovascular origin with a vasoactive drug combination].

Concrete cross-sectional studies of the organic brain syndrome, carried out periodically, attempt to establish for the parameters evaluation of substrate damage--and different noopsychopathological rating-scales for the measurement of brain capacity impairment. Beyond the level of the purely correlative-statistical point of view of the relationship between parameter and score changes, demanding for a quantitative model which could provide not only a description, but also an explanation for such a relationship. The fact that there can only be a question here of a "quantitative causality" embracing non-specificity of toxic substances and relative to acute and chronic diffuse organic brain syndromes. It results, that quantitative causality meets the requirements of an exponential function model and that one can validate such models through correlative-statistical methods. This has already been carried out by Ball and Taylor.

Adult↗
PubMed1984

[Effects of metacaine and its decomposition products on the excitation mechanism of isolated myelinated nerve fibers].

The blocking effects of metacaine-methanesulfonate (MS-222; abbreviated MMS) and of the corresponding hydrochloride (MHC) on the ionic currents in potential clamped myelinated nerve fibres were investigated. The dose-response relationships of MMS for blocking the Na-currents and K-currents could be satisfactorily fitted to the Langmuir adsorption isotherm with KNa = 0.7 mmol/l and KK = 1.8 mmol/l. The observed loss of efficacy in blocking ionic currents of 3-day-old solutions containing MMS was assumed to be due to a partial decomposition of the drug. We separated the water-soluble decomposition products by extraction of the metacaine base. The remaining aqueous solution showed an anti-blocking effect on metacaine blocked Na-currents. From corresponding experiments on the blocking effect of MHC we conclude that the anti-blocking effect is due to yet unknown decomposition products, formed in MMS but not in MHC solutions.

Aminobenzoates↗
PubMed1980

[Escherichia coli O151:K-:h10 ("krim") as etiologic agent of diarrhoea (author's transl)].

The first time infections by Escherichia coli O 151:K-:H10 were reported from Japan and the Soviet Union. 1972 it was included into the international antigenic scheme. Since 1976 these germs were occasionally demonstrated in sporadically occurred acute enteritis in th G.D.R. In autumn 1979 60 E. coli O 151 strains were isolated from accumulating cases of gastroenteritis in the Rostock district. These infections mainly concerned young children, but also adults. Microbiological properties of 87 isolates of this serogroup are described. Biological examination of these strains did not result in symptoms for invasive activity or enterotoxin production. An indirect reference to the existence of fimbrial antigens could be obtained by the Evans' method of direct hemagglutination. A corresponding hemagglutination pattern was found out in 60 E. coli O 151 strains tested: mannoseresistent hemagglutination of bovine and chicken erythrocytes. Hemagglutination pattern, association of these strains with enteritis and antigenic relations of Salmonellae motivated the recommendation to integrate these germs into the group of facultatively enteropathogenic Escherichiae coli described by Czirók and Evans. E. coli O 151 strains show biochemical particularities which can be useful for identification of these strains.

Adolescent↗
PubMed1978

Effects of vasopressin and its deamino-D-arginine analogue on renin release in the isolated perfused rat kidney.

The direct action of arginine-vasopressin (AVP) and its deamino-D-arginine analogue (DDAVP) on renin release (RR) has been studied in isolated rat kidneys perfused with an electrolyte solution at constant pressure in a single-pass system. AVP and DDAVP infused at various concentrations (80 to 2100 pg/ml and 80 to 8700 pg/ml, respectively) reduced volume and increased osmolality of urine in a dose-dependent way. High doses of AVP reduced renal perfusate flow and glomerular filtration rate while DDAVP had no effect on renal haemodynamics. When vasoconstrictor doses of AVP or high concentrations of DDAVP were infused, "basal" RR remained unchanged. However, when RR had been stimulated by infusion of isoproterenol, vasoconstrictor doses of AVP as well as high doses of DDAVP which did not increase renal vascular resistance diminished RR by about 30% (P less than 0.01, and P less than 0.05, respectively). These results suggest that the inhibition of RR by vasopressin is not related to its vasoconstrictor action.

Animals↗
PubMed1978

[Tracheotomy].

Explore the source record for details and available documents.

Aged↗
PubMed1978

Role of cyclic AMP in the regulation of renin release from the isolated perfused rat kidney.

The role of cyclic AMP in the regulation of renin release (RR) was studied in isolated rat kidneys, which were perfused at constant pressure in a single-pass system with a modified Krebs-henseleit solution. Isoproterenol (IP) (2 x 10(-9) to 2 x 10(-6) M) and 3-isobutyl-1-methyl-xanthine (IBMX) (4 x 10(-7) to 7 x 10(-5) M) induced a dose-dependent increase of renal perfusate flow, glomerular filtration rate and urinary sodium excretion. RR was stimulated up to 10-fold above control values within 5 min. At the lowest concentrations IP stimulated RR, but did not affect renal haemodynamics. When IP and IBMX were administered concomitantly, a supraadditive stimulation of RR was observed. Dibutyryl-cAMP (db-cAMP) and 8-Br-cGMP (10(-6) to 10(-4) M) produced a similar dose-dependent vasodilation and natriuresis, but differed in their action on RR. Within 15 min after the start of the infusion, db-cAMP increased RR up to 4-fold, whereas 8-Br-cGMP was without an effect. These results suggest that IP, IBMX and db-cAMP stimulated RR by increasing the concentrations of cAMP in the epitheloid cells and independently of changes in renal haemodynamics and sodium excretion.

1-Methyl-3-isobutylxanthine↗
PubMed1978

Chronic hypokalemic nephropathy: a clinical study.

Description of 23 patients (21 women, 2 men) with an average age of 36.6 (19--68) years, who were hypokalemic during 6.5 years on the average (range 1/2--16 years). The cause of the potassium depletion was malnutrition (anorexia nervosa, vomiting) and/or abuse of laxatives and/or diuretics. With increasing duration of potassium depletion renal function deteriorated; in two cases terminal renal failure developed. Histology of the kidneys (9 cases) showed the picture of chronic abacterial interstitial nephritis. Urinalysis was negative or non-specific. The blood pressure levels were normal or low, hypertensive values being exceptional. Aside of hypokalemia a tendency to hyponatriemia, hypochloremia and metabolic alcalosis was observed, the latter turning into hypokalemic normochloremic acidosis with advancing renal insufficiency. Plasma renin activity and aldosterone concentration or excretion frequently were elevated, but no close correlation was found between these parameters or with the blood pressure. Bacterial infection of the urinary tract occured, if at all, in the late phase and seems to be complication rather than the cause of the kidney disease. The discussion of other possible pathogenetic factors leads to the conclusion that the term "chronic kaliopenic nephropathy" is justified. Some diagnostic and therapeutic consequences are mentioned.

Adult↗
PubMed1978

[Results of surgical treatment of benign and malignant parotid tumors (author's transl)].

Of the total of 241 parotid tumors surgically treated between 1956 and 1975 at the Clinic of Otorhinolaryngology, Karl Marx University at Leipzig, 190 were of benign and 51, of malignant character. Patients of advanced age showed preferential development of parotid tumors. In more than ninety percent of the cases, the results of sialography were in agreement with surgical results. Surgical removal of the entire parotid gland was performed with the exception of those cases where the tumor showed good encapsulation and was confirmed to the pars superficialis of the parotid gland. Three cases of complete, permanent facial palsy resulted from surgical treatment of 190 cases of benign parotid tumors. The prognosis of malignant parotid tumors is extremely bad, and it is characterized by a proportion of successful surgical operations of only 26.5 percent.

Adolescent↗
PubMed1978

[Proteinase inhibiting agents and glucagon in acute pancreatitis (author's transl)].

In two prospective studies the effect of proteinase inhibiting agents and glucagon in acute pancreatitis have been studied by a randomised series. Moreover the effect of the basic therapy was examined in additional 103 patients. Symptoms, clinical and laboratory chemical findings correspond to each other in all collectives. The results seem to be the best ones in those patients having been treated by basic therapy only.

Acute Disease↗