Search PubMed⌕ Search

Biomedical subjects

U Teitelman

Publications and source records attributed to U Teitelman.

9 recordsLinked to original sources
PubMed1998

The acute effect of minocycline on the pericardium: experimental and clinical findings.

STUDY OBJECTIVES: To evaluate the acute effect of minocycline on the pericardium in the experimental animal and in the human with malignant pericardial disease. DESIGN: A prospective study in open-chest dogs and in humans. SETTING: Experimental surgery laboratory, medical school; coronary care unit, university hospital. METHODS: Twenty-three open-chest dogs were divided into four groups according to the solution injected intrapericardially: (1) minocycline, 5 mg/kg; (2) minocycline, 10 mg/kg; (3) normal saline solution, 100 mL, followed by minocycline, 10 mg/kg; (4) a mixture of 50 mL of the dog's own blood mixed ex vivo with minocycline, 10 mg/kg to evaluate the effect of rising pH of minocycline solution. The extent of myocardial injury is evaluated by measuring ST-T segment deviation in six standard bipolar leads and in three unipolar electrograms recorded over the left ventricular pericardial surface. The pH of the various minocycline solutions is measured. Nine consecutive patients with malignant cardiac tamponade receiving minocycline intrapericardially are evaluated for the appearance of chest pain and ECG changes. RESULTS: Minocycline (5 and 10 mg/kg) caused marked, transient ST-T segment deviation in all dogs, whether or not saline solution was previously injected into the pericardial sac. Prior mixing of minocycline with blood markedly increased the acidic pH of the minocycline solution and significantly reduced the extent of ST-T segment deviation. Four of nine patients had chest pain during minocycline injection. None had ST-T segment changes. CONCLUSION: Minocycline causes a marked, transient injury to the epicardial-pericardial surface. Our animal and in vitro studies indicate that this acute injury is probably partly related to the acidic pH of the minocycline solution. Our experimental findings suggest that this minocycline-induced injury may be reduced by raising the pH of the solution either ex vivo (eg, by mixing minocycline with previously withdrawn pericardial fluid) or in vivo (eg, by leaving 200 to 300 mL of pericardial fluid prior to minocycline injection). Limited experience in the human with malignant cardiac tamponade indicates that intrapericardial minocycline is usually well tolerated, although severe chest pain may appear.

Animals↗
PubMed1991

Manmade disasters.

A disaster that produces a multitude of patients may severely stress a community's health-care system, from the EMS system to the hospitals. Physicians involved in such an event must realize that they will have to change their normal mode of delivering care, having to make decisions with less than the normal amount of information, and doing the most good for the most salvageable patients. Some understanding of and appreciation for the unique problems that face emergency personnel in the field are important for physicians who do not normally interact with fire and EMS personnel, because it will allow them to realize that they are not alone in the chaos of a disaster. Many manmade disasters produce patients with medical or surgical problems with which one is familiar, the only difference being the sheer number of patients. Other manmade disasters, however, most notably those involving hazardous materials and radioactive materials, are capable of producing patients who not only have unfamiliar medical problems but also have problems about which little information is readily available in the medical literature. Hospital physicians can do much to prepare themselves for these eventualities. Discussion and planning should be done among separate staffs (ICU, operating suite, emergency department), as well as among staff of the various disciplines so they can interact more effectively when a disaster occurs. Local disaster planners should receive input from hospital staffs so hospital capabilities are known and the field operation can mesh well with the hospital's operation.

Chemical Warfare↗
PubMed1986

[Fire toxicology].

Explore the source record for details and available documents.

Burns, Inhalation↗
PubMed1985

Effect of methyl prednisolone on normobaric pulmonary oxygen toxicity in rats.

Male albino rats were exposed to 81, 86, 90 or 99% oxygen until death. Rats were also administered methyl prednisolone (MP) 10-60 mg/kg/day intraperitoneally. MP-treated rats survived significantly less than controls: 53.5 +/- 4.7 vs. 65.2 +/- 8.2 h, p less than 0.001 in 99% O2, 74.4 +/- 9.4 vs. 120 +/- 39.8 h, p less than 0.02 in 86% O2 and 113.7 +/- 21.4 vs. 162 +/- 17.9 h, p less than 0.03 in 81% O2. Rats were exposed to 99% O2 for 10, 30 and 50 h and the activity of superoxide dismutase (SOD) and catalase in their lungs was monitored. MP-treated rats showed less increase in pulmonary SOD after 10 h (111 vs. 171%, p less than 0.03) but no effect on SOD activity thereafter. MP had no effect on the response of catalase to O2. No effect of MP on lung morphology could be found under the light microscope.

Animals↗
PubMed1985

Relationship between plasma and stimulated-saliva concentrations of theophylline in asthmatic children.

The trough steady-state concentration of theophylline in plasma and stimulated saliva of 12 asthmatic children receiving an oral slow-release theophylline preparation was determined after 1 week of treatment. Plasma theophylline concentration ranged from 3.6 to 10.8 microgram/ml and saliva concentration ranged from 3.2 to 7.0 microgram/ml. There was an excellent linear relationship between theophylline concentration in plasma and stimulated saliva (r=0.89, p is less than 0.001). These observations suggest that theophylline therapy could be monitored routinely using stimulated saliva. This may be a convenient, painless and non-invasive alternative for routine monitoring of theophylline levels in asthmatic children.

Asthma↗
PubMed1983

Computerized medical reasoning in diagnosis and treatment of acid-base disorders.

A system is described for aiding the clinician in the management of acid-base disorders. The medical knowledge required for interpretation of blood gas measurements, etiologic diagnosis, and treatment selection for acid-base disorders is structured into decision pathways consisting of a series of inferences. Each inference is defined by a medical logic module which specifies the different combinations of criteria, patient data and/or previously confirmed inferences, sufficient for confirming or rejecting the inference. A method is provided for converting numerical observations to the appropriate logical statement used in the modules. Patient data are compared to the medical logic and a status report lists the input data, acid-base diagnosis, and the suggested therapy. After initial testing on patient data, the medical logic was updated to express the medical policy of our clinical specialists. The system was applied to 54 patients and the system's conclusions were in full agreement with our staff in 93% of the cases, and in partial agreement in the other cases. The modular structure of the system's medical knowledge allows full expression of all the nuances of medical policy in our unit and facilitates updating to encompass the latest developments in acid-base management. The system can be integrated readily into existing computerized patient monitoring systems.

Acid-Base Imbalance↗