Search PubMed⌕ Search

Biomedical subjects

U Steiger

Publications and source records attributed to U Steiger.

At least 19 recordsLinked to original sources
PubMed1992

["Psychogenic" bulbar paralysis].

This 58-year-old female presented with a history of difficulties in swallowing for 30 years. No diagnosis was made in spite of repeated investigations including barium-contrast radiography. A probative strumectomy and psychotherapy were unsuccessful. After an episode of major depression the swallowing disturbances increased. In addition the patient complained of mastication difficulties and was dysarthric. Finally, neurological examination and neurophysiological studies established the diagnosis of progressive bulbar palsy.

Bulbar Palsy, Progressive↗
PubMed1992

[Rare form of uveitis with neurological symptoms: the Vogt-Koyanagi-Harada uveomeningoencephalitic syndrome].

A 51-year-old Italian woman developed migraine-like headaches with increasing frequency 5 years after menopause. The simultaneous onset of severe bilateral uveitis, neurological signs such as vertigo, hearing loss, small sensomotor hemisyndrome, cognitive brain dysfunction and lymphocyte liquor pleocytosis confirmed the diagnosis of Vogt-Koyanagi-Harada syndrome, a rare disease of probably autoimmune origin with destruction of pigment containing neuroepithelium. Other vasculitic diseases, especially those of infectious or rheumatologic origin, were excluded. Systemic corticoid treatment suppressed the activity of the illness but on dose reduction relapses occurred. Additional immunosuppressive medication prevented uveitic relapses and made it possible to reduce the corticoid dose.

Cyclophosphamide↗
PubMed1990

Albendazole kinetics in patients with echinococcosis: delayed absorption and impaired elimination in cholestasis.

The pharmacokinetics of albendazole and its main metabolite, albendazole sulphoxide, have been examined after giving a single oral dose of 200 mg albendazole to 19 patients with either Echinococcus multilocularis or E. granulosus, 5 of whom had significant extrahepatic obstruction due to the underlying disease. The AUC of albendazole sulphoxide was increased in the latter patients (mean 122 mumols.h.l-1 compared to 17 mumols.h.l-1 in the non-obstructed group). Obstructed patients had delayed absorption, ka averaging 0.39 compared to 1.41 h-1 in non-obstructed patients. The corresponding elimination rate constant, ke was also prolonged, averaging 0.041 and 0.13 h-1 in the two groups, respectively. Four patients were restudied after complete or partial resolution of the cholestasis. The pharmacokinetic parameters in them had returned towards values comparable to those in the non-obstructed patients.

Adult↗
PubMed1990

Albendazole treatment of echinococcosis in humans: effects on microsomal metabolism and drug tolerance.

We prospectively studied the effect of albendazole on microsomal reserve and on first-pass activation to albendazole sulfoxide in patients with hydatid disease. An aminopyrine breath test was performed in 12 patients while they were receiving albendazole treatment and while they were not. Excretion of 14CO2 in breath averaged 0.70%.kg.mmol-1 +/- 0.20%.kg.mmol-1 without treatment and 0.54%.kg.mmol-1 +/- 0.14%.kg.mmol-1 with treatment (p less than 0.005). Plasma levels of albendazole sulfoxide were measured 4 hours after the morning dose during the first and second half of the 4-week treatment cycles. In nine of the 12 patients albendazole sulfoxide levels decreased during the second half of the cycle by an average of 0.84 +/- 0.76 mumol/L (p less than 0.02). Transaminase levels increased in 10 of the 12 patients during long-term albendazole treatment, and major side effects, including hepatotoxicity, neutropenia, and alopecia, were observed in three patients. We conclude that albendazole partially inhibits microsomal enzyme function but induces its own metabolism. Hepatotoxicity and other possible severe side effects necessitate close therapeutic monitoring of patients who are given albendazole.

Adult↗
PubMed1990

Recurrence rate after discontinuation of long-term mebendazole therapy in alveolar echinococcosis (preliminary results).

The recurrence rate was investigated in 19 patients with non-resectable alveolar echinococcosis after discontinuation of a long-term therapy with mebendazole (average treatment 4.3 years). A control group consisted of 14 patients who underwent radical surgery and finished a course of prophylactic postoperative mebendazole treatment of 2 years. In the controls, no recurrence was observed after a post-therapy period averaging 3.5 years. In contrast, recurrence occurred in 7/19 patients (37%) with non-resectable alveolar echinococcosis an average of 1.6 years after discontinuation of the long-term mebendazole therapy. The absence of clinically detectable recurrence in the remaining 12 patients seems to be due either to spontaneous inactivation of alveolar echinococcosis preceding chemotherapy or too short post-therapy surveillance. The patients with recurrence responded favorably to reintroduction of chemotherapy. The data indicate that mebendazole therapy is parasitostatic rather than parasiticidal.

Adult↗
PubMed1989

[Eosinophilic fasciitis with aplastic anemia and Hashimoto's thyroiditis. Review of the literature and report of a typical example].

Eosinophilic fasciitis (EF), described for the first time in 1974 by Shulman, is characterized by induration and inflammation of the fascia of the extremities. The disorder is associated with peripheral blood eosinophilia, hypergammaglobulinemia and an elevated erythrocyte sedimentation rate. In most patients the clinical and laboratory features improve following administration of systemic corticosteroids. Since 1978 several patients with EF and various hematologic disorders have been described. In this report we present a female patient aged 62 exhibiting, besides symptoms indicative of EF, features of Hashimoto thyroiditis and aplastic anemia. In the review of the literature we compare 209 patients with EF including 15 cases with additional hematologic disorder.

Anemia, Aplastic↗
PubMed1986

Arthroplasty of the elbow. Experience with the Mark III GSB prosthesis.

Forty-five total elbow replacements using the Mark III GSB prosthesis are reviewed. Average follow-up was 2.7 years. The overall results were good in 87% of cases, fair in 9%, and poor in 4%. Excluding the two poor results, which required prosthesis removal, 96% of cases had no significant pain. The flexion/extension are improved 24 degrees and the supination/pronation arc improved 22 degrees. No prosthesis was loose and only one had a significant radiolucent line. The overall complication rate was 25%. Disassembling of the two components, due to inadequate ligament tension, was the most frequent complication and this occurred in four elbows.

Adult↗
PubMed1985

[Results of tibia condyle osteotomy].

The subjective and objective results of infra-condylar tibia condyle osteotomy are presented, based on a study of 71 cases. Arthroplasty of the knee joint can often be avoided by performing an infra-condylar tibia condyle osteotomy, taking into consideration the contra-indications, in cases of painful (varus) gonarthrosis becoming mainly manifest in a joint compartment, combined with an axis shift. The gait capacity can be improved, the subjective pain symptomatology be diminished and progression of the arthrosis might be avoided. The good results correlate with an optimal correction of the axis condition; in cases of varus gonarthrosis a slight overcorrection beyond the physiological valgus position of 7 degrees and in cases of valgus gonarthrosis a physiological valgus position of 7 degrees should be aimed at.

Adult↗
PubMed1983

[Systemic chronic juvenile arthritis (Still's disease) in adults. Review of the literature].

UNLABELLED: The entire literature up to the present of 119 patients described as having adult Still's disease is reviewed. Clinical, laboratory, radiological and histological findings, treatment, follow-up and outcome are presented. 1. CLINICAL FINDINGS: All patients had arthralgias and/or myalgias. Seven did not fulfill strict diagnostic criteria as they did not have overt arthritis. All had fever, and 93% had septic fever with temperature peaks of greater than or equal to 39 degrees C. The characteristic maculo-papular rash was present in 89%. Other findings were sore throat, lymphadenopathy, splenomegaly (in about 50% each), weight loss, pericarditis, hepatomegaly, pleuritis (in 1/4 to 1/3 of the cases each). Less frequent were alopecia, pneumonitis and abdominal pain (in less than 10% each). 2. LABORATORY FINDINGS: The ESR was uniformly elevated. Over 90% of the patients exhibited neutrophilic leukocytosis. Anemia, hypoalbuminemia and pathologic liver function tests were found in 60-80%. IgM-RF and ANA were both negative in 95% of the patients and hence were not more frequently present than in the normal population. 3. X-ray findings: There were no pathognomonic radiological abnormalities of the joints. Nevertheless, the tendency to ankylosis, especially of the carpus, seems to be typical. A few patients developed severe destructive lesions, especially of the hip and shoulder joints. 4. Biopsies: Many biopsies were performed and did not reveal specific histologic abnormalities. Nonetheless, they sometimes are necessary in order to exclude other disease entities. 5. Treatment, follow-up, prognosis: Therapeutically high-dosage ASA and (if necessary) systemic steroids are recommended for the acute phase. The efficacy of this treatment is controversial. Even after successful control of the acute disease, exacerbations are frequent for many years. Despite the initial optimism, there is significant long-term morbidity due to recurrent disease flare-ups on the one hand, and articular destructions in some patients on the other.

Adult↗
PubMed1983

[Still's disease in adults. 2 case reports].

Two patients with adult Still's disease are presented. Both had high "septic" fever, weight loss, mild pharyngitis, evanescent maculo-papular rash, myalgias, arthralgias, splenomegaly and pericarditis, while one of the two patients also had lymphadenopathy and pleurisy. Arthritis, which is a sine qua non for the diagnosis, developed only 5 months after disease onset in one patient. Both ultimately developed severe destructive joint disease requiring hip arthroplasty. Laboratory findings were neutrophilic leukocytosis, normochromic normocytic anemia, elevated ESR, slightly elevated liver enzyme values, negative IgM-rheumatoid factor and antinuclear antibodies, and normal or slightly elevated complement factors. Several biopsies failed to reveal pathognomonic findings. It is of the utmost importance that the exclusion diagnosis of adult Still's disease be posed in order to avoid repeated hospitalizations with undue investigations and unnecessary therapeutic trials with antibiotics.

Adult↗
PubMed1980

[Functional backache].

Although functional pain must be accepted as a fact by the patient and his physician, the relevant somatic investigation is indicated. The localization of musculoskeletal pain always corresponds to intensified local strain on the locomotor system. By instruction regarding the connection of pain with strain the patient learns to keep his functional pains within tolerable limits by active control of the loads and stresses on his own body. Aggressive diagnostic or therapeutic measures often increase the problem.

Back Pain↗
PubMed1980

[Management of the geriatric patients with osteoarthrosis (author's transl)].

A knowledge of the differential diagnosis of osteoarthrosis and its predicted natural course is essential in the management of patients with this disease. The prognosis is usually better than is generally accepted; osteoarthrosis is the remodelling of a joint defect rather than a progressive disease. An explanation of the origin of his pain is more important to the patient than medical treatment. He should be helped to strike a balance between protection of the diseased joints, thus preventing traumatisation and therefore new painful inflammation on the one hand, while maintaining active use of his joints which is important in their remodeling and adaptation on the other. Some pain on weightbearing has to be accepted as a physiological joint protection.

Aged↗