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Biomedical subjects

U Stamer

Publications and source records attributed to U Stamer.

13 recordsLinked to original sources
PubMed2006

[Genetics, pain and analgesia].

Genomic variations influencing nociceptive sensitivity and susceptibility to pain conditions, as well as responses to pharmacotherapy of pain are currently under investigation. Candidate genes involved in pain perception, pain processing and pain management such as (opioid) receptors, transporters and other targets of pharmacotherapy are discussed. Drug metabolizing enzymes represent a further major target of ongoing research in order to identify associations between an individual's genetic profile and drug response (pharmacogenetics). Polymorphisms of the cytochrome P 450 enzymes influence analgesic efficacy of codeine, tramadol and tricyclic antidepressants (CYP2D6). Blood levels of some non-steroidal anti-inflammatory drugs (NSAIDs) are dependent on CYP2C9 activity, whereas opioid receptor polymorphisms are discussed with respect to differences in opioid-mediated analgesia and side-effects. Pharmacogenetics is seen as a potential diagnostic tool for improving patient therapy and care and will contribute to a more individualized drug treatment in the future.

Analgesia↗
PubMed2005

[Does genomics determine efficacy of analgesics?].

Recent advances in knowledge about gene structure derived from the human genome project has also revealed data on genomic variation and their possible impact on complex and acute diseases as well as pharmacotherapy. The hypothesis of a genetic predisposition for complex diseases such as pain syndromes, side effects, and adverse outcomes challenging the clinician is ready to be tested by advanced genetic-epidemiologic study designs employing the latest genotyping technology. In pain therapy, the genetic background of the efficacy of analgesics, especially of opioids, is of particular interest. Genetic differences in drug kinetics and dynamics, e.g., differences in metabolism or genetic variations of the drug target (e.g., receptors) will be of importance in the future. Pharmacogenetics can individualize pharmacotherapy and improve care by predicting the optimal dose and avoiding side effects and toxicity in individual patients.

Analgesia↗
PubMed2004

Prolonged restaurant-associated outbreak of multidrug-resistant Salmonella Typhimurium among patients from several European countries.

This report concerns a prolonged restaurant-associated outbreak of infection caused by a multidrug-resistant (ASSuT) strain of Salmonella Typhimurium, phage-type U302, which took place during July and August 2003 and affected people from Denmark and neighbouring countries who had attended a specific restaurant. The outbreak comprised 67 laboratory-verified cases and ten probable cases; however, the actual number of patients was estimated to be more than 390. The outbreak strain was isolated from a buffet which was probably contaminated by an assistant chef who was found to excrete the epidemic strain. An attack rate of 7.3% was estimated and long incubation periods were observed, including one extreme instance of 27 days. This outbreak underscores the importance of conscientious personal hygiene, including frequent washing of hands, for professionals handling food.

Adolescent↗
PubMed2002

[Postoperative pain therapy in Germany].

OBJECTIVE: A survey was performed to obtain information on the organization and practice of postoperative pain management. METHODS: A questionnaire was mailed to 773 directors of German departments of anesthesiology. RESULTS: A total of 446 replies (57.7%) could be analyzed. Of the departments, 161 (36.1%) had established an acute pain service (APS), more often in hospitals > or = 1000 beds (63%) than in hospitals with 400-999 beds (40%) and hospitals with < 400 beds (27%). Epidural analgesia was practiced in 97% of the departments, however, it was the analgesic technique of choice for larger abdominal surgery or amputation of the lower limb only in 60.8% and 45.5% of the departments, respectively. Departments with APS provided epidural analgesia more often on general wards than departments without APS (88.2% vs. 68.4%, p < 0.01). Technically more challenging methods (e.g. catheters for regional anesthesia, PCA, PCEA) were more often provided in hospitals running an APS (p < 0.001). CONCLUSIONS: The number of departments with APS has increased over the last 10 years. Future decisions on reimbursement should consider this extensive service.

Analgesia, Epidural↗
PubMed1998

[Current practices in anesthesia for cesarean section in german university clinics. Results of a survey in the year 1996].

UNLABELLED: Obviously there is a world-wide trend towards regional anaesthesia for caesarean section (CS). Data on the current practice in Germany are lacking. METHODS: In 1996 questionnaires on obstetric anaesthesia were mailed to all University departments of anaesthesia. RESULTS: All 38 University Hospitals with obstetric units replied (100%). Mean annual delivery rate was 1156 with a mean CS-rate of 24%. For scheduled CS the University departments used general anaesthesia in most cases (60%), followed by epidural (31%) and spinal anaesthesia (9%). General anaesthesia was predominantly used for more urgent (87%) or emergency deliveries (99%). Spinal anaesthesia was offered to patients as an option of anaesthesia for CS in 16 of 38 departments, epidural anaesthesia in 36 of 38. The majority of university hospitals (22 of 38) performed more than 25% of their CS in epidural anaesthesia; 14 departments had a ratio of at least 50% of regional anaesthesia. 28 of 32 centres administered some kind of acid aspiration chemoprophylaxis as a routine management. Special devices for the management of a difficult airway were provided in 61% of the hospitals within the delivery unit. In 70% the anaesthesiologist was responsible for the postoperative pain management following CS. CONCLUSION: A significant trend towards regional anaesthesia for CS has taken place in German university hospitals: According to a former survey regional anaesthesia was used in less than 10% of CS in 1977, whereas in the current evaluation from 1996 this figure was significantly higher (40%). Nevertheless, compared to other countries the rate of general anaesthesia still is rather high.

Anesthesia, Epidural↗
PubMed1998

[Current practices in obstetrical analgesia in German university clinics. Results of a 1996 survey. Part 2].

UNLABELLED: Obviously there is a world-wide trend towards regional analgesia for pain relief during delivery. Data on the current practice in Germany are lacking. METHODS: In 1996 questionnaires on obstetric anaesthesia and analgesia were mailed to all university departments of anaesthesia. RESULTS: All 38 university hospitals with obstetric units replied (100%). Mean annual delivery rate was 1156. Epidural analgesia (EA) (n = 22), intramuscular injection of opioids (n = 18), and non-opioids as a suppository (n = 17) were often used for pain relief during labour. Intravenous injections (n = 12) or pudendus anaesthesia (n = 7) were practised as well. Entonox (N2O/O2), paracervical blocks or transcutaneous electrical stimulation (TENS) was rarely used. EA for relief of labour pain was offered in all university hospitals. Twelve of them had an epidural rate of less than 10%, in nine the rate was 10-19%, in eight hospitals 20-29% and 30% or more in nine. Indication for EA was a demand by the parturient (n = 34), by the obstetrician (n = 26) or the midwife (n = 18), predominantly because of prolonged labour (n = 32) or significant pain (n = 21). Half of the university departments used an epidural combination of local anaesthetics (bupivacaine) and opioids (sufentanil (n = 12) and/or fentanyl (n = 9)). In all but one department the application of an epidural catheter was performed by anaesthesiologists exclusively. In some hospitals obstetricians (n = 10) or midwives (n = 4) were allowed to give epidural top-up injections. Of the 38 university departments 11 had an anaesthesiologists on duty 24 h a day responsible for the obstetric unit exclusively. CONCLUSION: In 1977, 14 of 18 university departments of anaesthesiology offered epidural analgesia for parturients. This option was available in all university departments in 1996. A mean rate of 10-20% epidurals for vaginal delivery is well within the limits reported from other countries, whereas the rate of regional anaesthesia for scheduled caesarean section (40%) still is rather low in Germany, as reported in part 1 of this survey (Anaesthesist 1998;47:59-63).

Adult↗
PubMed1996

[Forgotten pain].

A 55-year-old female patient developed a severe chronic lumbar pain syndrome over a period of 17 years. An intervertebral disc operation was performed 5 years after the start of the painful illness. The patient later developed resistance to therapy and was unable to stand or walk. She was confined to bed and wheelchair and socially completely withdrawn. Drug therapy and invasive therapeutic techniques escalated. An intrathecal catheter for morphine administration had to be removed owing to bacterial meningitis, and repeated malfunction led to several revisions of an epidural catheter. Withdrawal of the morphine therapy, carried out with the patient's agreement, was complicated by an epileptic seizure and an acute circulatory failure with cerebral hypoxia. The succeeding severe amnestic syndrome extinguished all recollection of the last 20 years, including the entire course of the painful illness. The patient could then be mobilised without pain. Consistent care avoided a relapse into the pain syndrome as the amnestic syndrome gradually receded. The patient was fully able to accept responsibility and not longer required special pain therapy. The course demonstrates that chronic pain disorders of a predominantly psychodynamic, and therefore corticocerebral, genesis are dependent on an intact memory. In such cases memory failure can induce pain relief.

English Abstract↗
PubMed1992

[Ambulatory epidural analgesia in patients with tumors. An outmoded technique?].

In 35 of 316 patients suffering from severe cancer pain, an epidural catheter was placed for continuous morphine application. Indications for epidural opiates included failure of pain relief with oral morphine, severe side effects with oral administration, and contraindications for oral morphine, e.g., ileus. METHODS. The epidural catheter was inserted in the lumbar, thoracic or cervical region, according to the main localization of pain. A silicon catheter with a Dacron cuff (4.2 F Broviac Davol, Cranston, R.I.) was connected and tunneled subcutaneously to a distant exit on the lateral chest wall (Fig. 2). A portable morphine pump (CADD-PCA Pharmacia Deltec) was connected to the externalized catheter. The morphine was infused continuously at a basic rate. It could be increased to a programmed limit by additional boli determined by the patients themselves. Thirty patients were treated as outpatients. RESULTS. The mean duration of treatment was 101 (10-333) days. The daily dose of morphine ranged from 9 to 200 (33) mg at the beginning of therapy, and from 20 to 288 (88) mg at the end of treatment. In 27 patients (77%) epidural morphine administration proved to be a valuable method of pain control (Fig. 3). Even in most cases of tolerance to oral morphine, especially in patients suffering from pain of neuropathic origin, pain control was adequate. There were no cases of continuous loss of effectiveness of continuous loss of effectiveness or development of tolerance (Fig. 5). The epidural morphine dosage depended on the character and intensity of pain and its responsiveness to epidural opiates. Technical complications were noticed in 6 patients (17%), and fairly mild side effects of epidural morphine occurred in 20% of the patients for a limited time. CONCLUSIONS. The technique described is a simple and convenient method for long-term treatment of cancer patients with epidural morphine. There was no need for more invasive procedures, such as intrathecal or intraventricular morphine administration, in this group of patients in whom no pain relief had been achieved with oral morphine administration.

Adult↗
PubMed1987

[Methods of electron microscopy studies of the uterine horn of the New Zealand rabbit following use of 4 different coagulation methods].

To study the effect of 4 different coagulation methods used for sterilization, the subsequent process of wound healing, and the regeneration capability of tissue electronmicroscopically the uterus horns of white New Zealand rabbits were coagulated by monopolar or bipolar high frequency current or by endocoagulation through pelviscopy or by the CO2-laser through laparotomy. For each procedure coagulation power resp. temperature, coagulation time and interval from operation to tissue examination were varied. The methods especially of tissue preparation and examination were described in detail.

Animals↗
PubMed1987

[Results of electron microscopy studies of the uterine horn of the New Zealand rabbit following use of 4 different coagulation methods].

The effect of 4 different coagulation methods used for sterilization, the subsequent process of wound healing, and the regeneration capability of tissue were investigated electron-microscopically. For that purpose, the uterus horns of white New Zealand rabbits were coagulated by monopolar or bipolar high frequency current or by endocoagulation through pelviscopy or by the CO2-laser through laparotomy. For each procedure coagulation power resp. temperature, coagulation time and interval from operation to tissue examination were varied. Monopolar and bipolar high frequency coagulation caused the largest zone of destruction, judged by the macroscopic, microscopic, and ultrastructural cell alterations. The nervus and blood vessels of the mesometrium were also subjected to coagulation effects. In endocoagulation, the destroyed area was limited to the tissue grasped by the crocodile forceps. The CO2-laser only produced a thin layer of coagulated tissue at the section edge. Altogether, only about 2-3 mm of tissue were destroyed. The small amount of tissue that had to be resorbed by inflammatory cells after endocoagulation allowed for a much more rapid healing process than after application of the two high frequency techniques. Characteristic of a healing process not completed even 5 months after monopolar high frequency coagulation, we saw carbonized necrotic remains and numerous macrophages and foreign body giant cells. Beginning or complete recanalization was found in 1/4 of the uterus horns operated by CO2-laser. An increased mitotic activity of undifferentiated cells indicated the attempts at complete reconstruction. The blastem-like tissue showed no differentiation towards ciliated or secretory epithelial cells yet. Endocoagulation should by preferred as the safer method for tubal sterilization because of the relatively small amount of tissue destruction, which, however, is sufficient for a complete separation of the uterus horns from the body, because the mesometrium is not damaged and because wound healing is quicker and adhesion formation is practically absent.

Animals↗