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Biomedical subjects

U Simeoni

Publications and source records attributed to U Simeoni.

60 records · Page 4Linked to original sources
PubMedDate not supplied

[Arterial blood pressure and arterial stiffness in adolescents are related to gestational age].

BACKGROUND: Recent studies show that low birth weight (LBW) infants are at risk of increased arterial blood pressure (BP) in adulthood. Previous work from our centre and others suggests that arterial stiffness (AS) is increased in such patients. However, the respective roles of preterm birth and of intrauterine growth restriction (IUGR) are unclear. AIM: To characterize AS and BP in adolescents who were: born at term with an appropriate birth weight for gestational age (GA) (group 1, n=41); born preterm with an appropriate birth weight for GA (group 2, n=25); born at term and small for GA (group 3, n=24). PATIENTS AND METHODS: Systemic BP was measured with an automated oscillometric device. AS was assessed by measuring pulse wave velocity (PWV) between carotid and radial arteries. RESULTS: 90 adolescents were studied at a mean (SD) age of 13.9 (1.2) years. Subjects from group 2 were born with a 33.6 (1.5) GA. Systolic BP, mean BP, and PWV were significantly increased in group 2 subjects in comparison to both group 1 (123 +/- 11 vs. 117 +/- 11 mmHg, p = 0.04; 88 +/- 7 vs. 83 +/- 7 mmHg, p = 0.03; 7.7 +/- 1.0 vs. 7.0 +/- 0.9 m/s, p = 0.02 respectively) and to group 3 (114 +/- 15 mmHg, p = 0.03: 79 +/- 8 mmHg, p = 0.001; 6.8 +/- 0.9 m/s, p = 0.005 respectively) subjects. Systolic BP, mean BP, and PWV were similar in group 1 and group 3 subjects. CONCLUSION: BP and AS are increased during adolescence in subjects born with a LBW due to preterm birth, while they are not altered in subjects when LBW is related to IUGR. It may be speculated that such changes predispose to long term hypertension and that preterm birth is involved in the early programming of arterial diseases in adulthood.

Adolescent↗
PubMedDate not supplied

[Branhamella catarrhalis in neonatal pulmonary infectious pathology].

Bronchopulmonary infections has been described for the most part in adults. ORL and upper respiratory tract infections are encountered in children. In neonates, only conjunctivitis have been reported. In their report, the authors describes the first cases of bronchopulmonary infections due to Branhamella Catarrhalis in premature infants with respiratory distress syndrome. Three cases are described in which this bacteria has been isolated in bronchial secretions and in the culture of the nasotracheal tube. Clinical and biological features were not specific. Only orosomucoid serum level was increased. A favourable outcome was obtained by macrolides. Epidemiological survey permitted the isolation of Branhamella Catarrhalis in one of the nurse who had taken care of the neonates. Otherwise, these infections occurs in immunologically compromised hosts. Hyaline membrane disease appears most likely as an auspicious factor.

Bacterial Infections↗
PubMedDate not supplied

[Temporary auxiliary orthotopic transplantation of a reduced liver for fulminant hepatitis. A successful case in a child].

A 4 years boy with fulminant hepatitis due to virus A, underwent a temporary auxiliary liver transplantation. The graft which consisted in an adult reduced-liver, was implanted orthotopically after a left hepatectomy was performed on the recipient own liver. A good liver function was immediately restituted and the remaining native liver, that was 90% necrotic at time of transplantation, regained normal histological structure within 3 months. The auxiliary graft was then removed and immunosuppressive therapy permanently stopped.

Biopsy↗
PubMedDate not supplied

[Nitric oxide (NO) and normal and pathologic renal development].

Nitric oxide (NO) has been identified as the mediator accounting for the biological effects of endothelium-derived relaxing factor (EDRF) and has been shown to be generated by the action of constitutive and inducible NO-synthases (NOSs) from L-arginine in a variety of cells, including macrophages, neurons and endothelial cells. NO acts as an autocrine or paracrine mediator, its half-life being very short, within the range of few seconds. The NO produced in endothelial cells exerts potent, regional vasodilatatory effects. In the kidney, NO has been shown to play a key role in various processes in normal and pathological conditions. NO is involved in the control of renal basal vascular tone and the maintenance of low vascular resistance. Increasing data suggest that NO interacts with the renin angiotensin system to ultimately influence renal haemodynamic function.

Animals↗