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Biomedical subjects

U Schneyer

Publications and source records attributed to U Schneyer.

31 records · Page 2Linked to original sources
PubMed1982

[Studies on the incidence of diabetes mellitus in obese patients].

In a retrospective investigation 228 obese persons with healthy metabolism and diabetics (NIDD) were invited to a check-up 4-10 years after a reduction of weight which was performed during a clinical treatment in the 2nd Medical Clinic of Halle University. 95 patients did not comply with the invitation, 9 patients had died in the meantime. Among the 24 obese persons examined were 9 patients with NIDD. In other 19 patients a diabetic metabolic disturbance had become manifest in the meantime. 78 obese persons underwent a clinical examination, among them 9 NIDD. 60 patients had a normal and 18 a pathological carbohydrate tolerance. Of these 18 patients in 9 patients an up to now unknown diabetes mellitus could be proved. The obesity coincides with a relatively high rate of disturbed carbohydrate tolerance and a larger proportion of manifest diabetics compared with the normal population. In the own group of patients the morbidity of diabetes among the obese persons increases from 10.5 to 30% after on an average 7 years. Obese persons who had essentially exceeded their initial weight in the meantime and show further metabolic disturbances are particularly endangered.

Adult↗
PubMed1981

[The value of growth hormone stimulation tests].

In 142 test persons the insulin hypoglycaemia test as well as the glucagon propranolol test were performed under the interrogation of a hyposomatotropism. The combination of these tests proved as suitable for the answers to this inquiry. The insulin hypoglycaemia test led in 29%, the propranolol glucagon test only in 6% to the false indication of a hyposomatotropism. Thus the propranolol glucagon test has the higher diagnostic certainty. Insulin hypoglycaemia test and propranolol glucagon test seem to have a different effect.

Glucagon↗
PubMed1981

[Peripheral thyroid function and TRH-TSH test in patients with acromegaly].

In 11 patients with acromegaly the peripheral thyroid hormones were determined and a TRH-TSH-test was carried out. Depending on the result of the determination of the growth hormone the patients were classified into two groups (active and inactive acromegaly). The serum thyroxin level and the T3-binding capacity were normal. Only in a few patients decreased triiodotyronine levels were found. Independent of the degree of activity of the acromegaly positive as well as negative TRH-TSH-tests were found. The struma in patients with acromegaly which is frequently to be observed seems to be in a causal connection with this disease. The examination show altogether that the control of the function of the thyroid gland and the TRH-TSH-test do not deliver an essential contribution for the diagnostics of acromegaly itself.

Acromegaly↗
PubMed1981

[Growth hormone secretion in growth retarded children and adolescents].

In 119 children and adolescents with restricted growth whose secretion of growth hormone (hGH) was investigated in the insulin hypoglycaemia test, different hGH-secretion patterns were found. 52.1% of the investigated persons showed a prestimulatory stress-conditioned hGH-secretion. There were no relations to age or to sex. The hypoglycaemia-conditioned secretion of hormone following this spontaneous release has quantitatively no relation to the size of the decrease of blood sugar. However, it is also determined by the trend of secretion in the pretest-phase. Different modes of synthesis and release are the cause for this behaviour. High spontaneous hGH-levels decrease the hypoglycaemia effect of the intravenously applied insulin. In 33.9% of the cases the levels of the growth hormone are lower during the proper test phase or only as high as in the preparation time. Twelve times the poststimulatory values simulated a hyposomatotropism. The eventual importance of the secretion patterns remains up to now unclear for the longitudinal growth.

Adolescent↗
PubMed1977

[Mechanism of effect and clinical use of antiandrogens].

It is reported on the possibilities of the application of anti-androgenics, especially of cyproterone acetate. The indication extends to hirsutism, sexual deviations, growth disturbances in pubertas praecox as well as diseases of the prostate. Particularly strong standard are to be applied in the treatment of fertile women, as there exists the danger of an intrauterine feminisation of male foetuses, when a pregnancy was not absolutely excluded. Side-effects and results of animal experiments are mentioned. The therapeutic mechanism of the anti-androgenics can be explained with the help of a concurrency mechanism at the androgen receptor or acceptor.

Acne Vulgaris↗
PubMed1977

[Studies on stress-conditioned secretion of somatotropin].

72 of 413 adults and 55 of 112 children with intact function of the hypophysis revealed secretions of the growth hormone already in the preparation time for a clinical test. These variations of the HGH basal levels must be regarded as conditioned on test. In the judgment of the function of the anterior lobe of the pituitary gland with the help of the dynamics of the HGH-secretion the changes in the pretest-period should be included in order to avoid false diagnoses. From the secretion of the growth hormone conditioned on stress hitherto no conclusions can be made to the following course of the HGH-secretion.

Adolescent↗
PubMed1975

[Studies on the behavior of human growth hormone (HGH) level in the preparation period for the clinical test].

Behaviour of human growth hormone (HGH) during preparation for a clinical test. 172 adults and 63 children were examined for the behaviour of their HGH basic values during preparation for a clinical test. Even before the beginning of the stimulation itself 11% of the adults and 47,5% of the children showed a fluctuation of the HGH levels in the serum. Neglect of these HGH movements involves the risk of misinterpretation and thus of false diagnosis. It therefore appears to be essential, especially for judging stunted-growth forms in childhood, to make tests for "empty stomach" values for the purpose of HGH determination at least 30 minutes before and immediately at the beginning of the stimulation test. The behaviour of the basic values must be included in the assessment of the test.

Acromegaly↗
PubMedDate not supplied

HCG induced hyperthyreosis in germ cell cancer.

Human germ cell tumors have the unique capacity for totipotential differentiation. AFP (the product of normal yolk sac) and HCG (produced by trophoblastic tissues) are frequently produced by germ cell tumors. The a-subunit of the glycoprotein HCG is identical to that of several pituitary glycoprotein hormones (e.g. TSH, LH, FSH), whereas the b-subunit of HCG, TSH, LH and FSH is homologous but distinct in the terminal amino acid sequence suggesting that HCG is part of a superfamily of gestational hormones. However, the role of TSH within this hormone superfamily is still not yet established. A 24-year old patient was admitted to our clinic because of a widespread recurrence of a germ cell tumor (stage IIIC, Lugano classification). The routine hematologic and blood chemical tests were normal, yet, an elevated HCG was found. In addition, increased levels of the thyroid hormones FT3 and FT4 were seen, although, this was not associated with clinical symptoms of a hyperthyreosis. There was no history of hyperthyreosis and thyroidal autoantibody screening revealed normal titers. An ultrasound examination of the thyroid gland showed no abnormalities and no iodine exposure had occurred during the last months. To mobilize peripheral stem cells (PBSC) he was initially treated with paclitaxel (175 mg/m2) and ifosfamide (8.000 mg/m2)) followed by apheresis of PBSC. The patient was then entered in our phase-II-study for relapsing germ cell carcinomas using a high-dose chemotherapy regime (paclitaxel 175 mg/m2, ifosfamide 9.000 mg/m2, carboplatin 900 mg/m2, etoposide 900 mg/m2) with subsequent retransfusion of collected stem cells. Due to cranial metastases an cranial irradiation was also performed. After three courses of this protocol an excellent partial remission of the tumor lesions was achieved and the HCG value dramatically decreased. Due to elevated thyroidal hormones, the patient was initially treated with thiamazole (20 mg) resulting in decrease of the thyroidal hormones. Thus, the thiamazole dose was reduced to 5 mg and then omitted. The decrease of the thyroidal hormones FT3 and FT4 strongly correlated with the reduction of HCG values (r2 0.91 and 0.77, p < 0.0008). To date there is only slight evidence that enhanced HCG levels may cause, at least in part, a hyperthyreosis (e.g. gestational hyperthyreosis), however, the underlying biochemical mechanism still remains unclear. In this case report we have demonstrated a clear positive correlation between HCG levels and thyroidal hormones in a patient with germ cell tumor suggesting a direct stimulation of hormone producing thyroidal cells by HCG, however, this was not associated with clinical symptoms of hyperthyreosis. Currently, several in vitro studies are underway in our laboratory to further elucidate the biochemical mechanisms of HCG induced hyperthyreosis.

Adult↗