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Biomedical subjects

U S Barzel

Publications and source records attributed to U S Barzel.

At least 55 records · Page 3Linked to original sources
PubMed1981

Parathyroid surgery in the aged.

The results of parathyroid exploration in a group of elderly patients with the diagnosis of hyperparathyroidism were compared with those in a younger group and were found to be similar with 92% cure rate and 3% permanent complication rate. The criteria for deciding to subject an elderly patient to parathyroid surgery should therefore the same in the elderly as in the younger patients and age per se should play no role in the decision. Life expectancy, on the other hand should be taken into account.

Adult↗
PubMed1981

Clinical hypothyroidism in the elderly--a preventable disorder?

Among 27 ambulatory aged patients receiving thyroxine therapy for hypothyroidism, 4 had the "failing thyroid syndrome" (FTS) and 23 had frank clinical hypothyroidism. Patients with FTS are asymptomatic and the subnormal thyroid function is recognized only by a high level of serum thyrotropin (TSH) with a normal level of thyroid hormone (thyroxine or triiodothyronine). They require a smaller dosage of thyroid hormone for replacement initially. Identification of these cases through routine blood analyses for TSH in patients at risk (those with a history of Graves' disease or Hashimoto's thyroiditis) may permit early treatment of incipient hypothyroidism and the prevention of clinical hypothyroidism. Since there is a reduction in the thyroxine dosage required for complete replacement with age, the expected final replacement dosage when the thyroid fails completely is less than that reported for younger adults. This is true for patients with FTS, for patients with newly diagnosed clinical hypothyroidism, and for patients with long-established hypothyroidism receiving replacement therapy. The thyroid replacement dosage should be adjusted both for age and for body weight to avoid overdosage and thyroid toxicity, to which the elderly are particularly sensitive.

Aged↗
PubMed1977

The changing face of hyperparathyroidism.

Despite its earlier reputation as a relentlessly progressive disease, hyperparathyroidism may actually remain asymptomatic for many year. If its possible presence is signaled by hypercalcemia and supported by other laboratory findings, surgery is often indicated because no medical treatment is effective, and long-term follow-up of this frequently malignant condition is difficult; the surgical cure rate is about 95%.

Adult↗
PubMed1976

Ectopic hyperparathyroidism (pseudohyperparathyroidism) in esophageal malignancy. Report of a case and a review of the literature.

Described here is a patient with esophageal carcinoma who had hypercalcemia, an elevated serum level of parathyroid hormone and normal parathyroid glands. A review of the literature reveals that a total of 25 other patients with ectopic hyperparathyroidism in esophageal malignancy have been described, four of whom had documented elevations of serum parathyroid hormone levels. Esophageal neoplasms should be added to the list of tumors associated with ectopic secretion of parathyroid hormone.

Aged↗
PubMed1975

The effect of chronic ammonium chloride ingestion on parathyroid hormone function.

The purpose of this study was to examine the effect of ammonium chloride ingestion on the hypercalcemic effect of parathyroid hormone in vivo. Thyroparathyroidectomized rats were given 1.5% ammonium chloride for 5-6 days. Ingestion of ammonium chloride increased serum calcium, but also significantly enhanced the calcium elevating effect of injected parathyroid extract. This result is compatible with a proposed hypothesis that the calcium mobilizing function of the parathyroid hormone may be enhanced by the hormone's own influence on systemic hydrogen ion concentration.

Administration, Oral↗
PubMed1975

Studies in osteoporosis: the long-term effect of oophorectomy and of ammonium chloride ingestion on the bone of mature rats.

Adult female rats were subjected to a prolonged period of observation after oophorectomy. The oophorectomized animals and their controls were given a regular diet ad lib and water or ammonium chloride as their drinking fluid. Oophorectomy did not result in reduced bone density, fat free weight, total ash weight, or calcium content of the bone, thus failing to produce the changes of osteoporosis. Ammonium chloride ingestion caused significant decreases in the same parameters equally in normal and oophorectomized rats. Thus, oophorectomy neither leads to changes of osteoporosis, nor increases the sensitivity of the bone to ammonium chloride-induced osteoporosis.

Ammonium Chloride↗