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Biomedical subjects

U Runne

Publications and source records attributed to U Runne.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Erythema chronicum migrans with arthritis (author's transl)].

In a 46-year-old woman arthritis developed in several large joints eight weeks after the onset of erythema chronicum migrans. The joints of the leg were swollen and painful. In addition there was painful involvement bilaterally of knee, hip and elbow joints. Circulating immune complexes were demonstrated in serum and the erythrocyte sedimentation rate was moderately increased. All other laboratory and radiological tests were within normal limits. On symptomatic treatment the arthritis regressed without sequelae within six weeks. The disease is nosologically related to Lyme disease recently described in the North East of the U.S.A. in which erythema chronicum migrans is followed by arthritis; here, too, circulating immune complexes have been demonstrated.

Antigen-Antibody Complex↗
PubMed1980

[Verrucous leiomyoma of the scrotum presenting as condyloma acuminatum].

Verrucous Leiomyoma of the Scrotum Imitating Condyloma Acuminata. Solitary leiomyomas of the scrotum have an uncharacteristical clinical appearance therefore they are usually not recognized by clinicians. A 55 year old man was found to have multiple asymptomatic verrucous lesions on the scrotal wall which resembled condylomata acuminata. As a large disk-like induration (6 x 8 cm in diameter) could be palpated in the dermis of the anterior scrotal wall, the whole area was excised. Histologically a large multicentered leiomyoma of the tunica dartos was found.

Condylomata Acuminata↗
PubMed1980

[Budd-Chiari syndrome during treatment with dacarbazine (DTIC) (author's transl)].

Adjuvant chemo- and immuno-therapy with dacarbazine (1st to 5th day 250 mg/m2 daily) and BCG (6th day 0.01 ml intracutaneously)was administered to a 50-year-old male patient in a three-week cycle after surgical removal of a superficially spreading malignant melanoma. Metoclopramide was used as an antiemetic. During the second therapy cycle sudden severe vascular collapse with increasing hepatomegaly and signs of acute hepatic failure occurred leading to death after two days. At necropsy a Budd-Chiari syndrome with thombosed hepatic veins and congestive liver parenchyma necroses was found. The cause was hyperergic endophlebitis combined with severe infiltration of the vascular walls by eosinophilic granulocytes. In association with 5 more similar cases from other clinics (personal communications) this picture must be assumed to be a complication of dacarbazine treatment.

Budd-Chiari Syndrome↗
PubMed1980

[Partial synchronization and cytostatic combination therapy of disseminated malignant lymphomas of the skin].

Six patients with advanced disseminated malignant lymphomas of the skin were treated with cytostatics using the method of partial synchronisation of the tumor cell growth phases. Though five patients had already shown a resistance against the usual chemo- and/or radiotherapy, all patients responded to this therapeutical principle. Full remission was achieved in four patients. We proved that vincristine effectively synchronizes the growth of proliferating human tumor cells in vivo. Treatment was applied in two steps. First a partial synchronisation of tumor cell growth was induced by vincristine as a pharmacologic means. Then the cytostatics were applied in killing doses at the calculated time. For this purpose we determined the average length of each generation of cells and developed individual therapy schemes. To get the best results with this method usually several therapy cycles were used. In case of a relapse the therapy scheme was adjusted to the altered cellular kinetics. This principal of partial synchronisation is suitable for treating malignant lymphomas with high efficiency, especially those with rapid proliferation even in advanced states.

Adult↗
PubMed1979

[Double flap method in the frontal and temporal area to cover larger defects left by surgery].

Regional flaps are often necessary to cover defects left after operations in the forehead and temple area, since the skin of the scalp does not stretch well and because of the likelihood of dislocation of the eyebrow. We find the double advancement-flap technique using curving incisions of great use in this area. These curved flaps margins follow the wrinkles of the forehead and the relaxed skin tension lines. This contributes to easy healing and inconspicous scars. At the same time undersired facial asymmetry or disturbance of expression can be avoided.

Facial Asymmetry↗
PubMed1979

[Treatment of psoriasis using vitamin A, vitamin A acid and oral retinoids].

Vitamin A, Vitamin A acid (retinoic acid) and their synthetic derivatives were variously applied in the management of psoriasis with different therapeutic results. Obviously, they influence the proliferation rate and the differentiation of human keratinizing epithelia and have beneficial effects on skin diseases with disturbances of keratinization, including psoriasis. Systemic application of Vitamin A has been yet largely abandonned since high dosages leading to clearing develop evident systemic toxicity. The anti-psoriatic effect of Vitamin A acid is either moderate or restricted, because of side effects. Only its combined local application with topical corticosteroids may be considered. Oral application of newly synthesized retinoids, however, was beneficial in psoriasis, particularly in erythrodermic or pustular types. With this group of retinoids new pathways were opened in dermatotherapy which may help to replace cytostatic drugs in these cases. Additionally, oral retinoid treatment may be introduced as an adjuvans in the management of widespread psoriasis, in order to enhance the effect of anthralin, PUVA or UVB treatments.

Female↗
PubMed1978

[Subungual malignant lentigo with longitudinal nail pigmentation--diagnosis and surgical treatment].

A subungual Lentigo maligna was found to be the cause of a longitudinal melanotic stripe in the thumbnail of a 45-year old male. Because of the possibility of a malignant process, a histological diagnosis must be made in all cases of pigmented nail stripes. The best procedure is complete excision of the lesion in a bloodless field, followed immediately by frozen section analysis. According to the result either a larger operation is made during the same session or the wound closed. This procedure enables a specific therapy of pigmented subungual lesions, and contributes to the early recognition and prophylaxis of subungual malignant melanomas.

Amputation, Surgical↗
PubMed1978

[Severe generalized courses of zoster due to cellular immunologic defects. Importance of an absolute or relative T-cell deficiency].

Four patients with chronic lymphatic leukaemia, M. Hodgkin and metastatic breast carcinoma developed particularly severe generalised herpes zoster, with complications of herpes zoster pneumonia, signs of encephalitis and phrenic nerve paresis. Virus specific complement-fixing antibodies increased regularly or delayed, without strict correlation to the clinical course. However, in all these cases there was a relative or absolute deficiency of T-lymphocytes in the peripheral blood, as a result of the underlying illness and of treatment with cytostatic agents. Because of the vital role of cell-mediated immunity in the control of the varicella-zoster virus (VZV), the observed T-cell deficiency seems to be an important pre-condition for the development of severe generalised herpes zoster.

Adult↗
PubMed1978

[Lipoatrophia semicircularis in the male. Coincidence of arterial variations and micro-traumas as a possible disease cause].

Semicircular lipoatrophy is a new entity with horizontal depressions involving half the circumference of thigh, on the antero-lateral aspect. After seven female patients we observed this condition for the first time in the male. Therefore semicircular lipoatrophy is not specific to the female. The cause could not be determined clinically, nor by biochemical, immunological or histological methods. In our opinion semicircular lipoatrophy represents an ischemic atrophy of the fatty tissue, manifested by repeated microtraumata (corners of wash-basins, dressing tables or desks). The perfusion on the antero-lateral aspect of the thighs is tenous, especially when the course of the lateral femoral circumflex artery varies from the normal. In this case semicircular anastomotic areas become ischemic and horizontal bands of lipoatrophy result.

Adipose Tissue↗