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Biomedical subjects

U P Kalyanaraman

Publications and source records attributed to U P Kalyanaraman.

12 recordsLinked to original sources
PubMed1983

Neuromyopathy of cyanide intoxication due to "laetrile" (amygdalin). A clinicopathologic study.

A 67-year-old woman with lymphoma presented with a neuromyopathy following "laetrile" (amygdalin) treatment. She had significant elevation of blood and urinary thiocyanate and cyanide levels. Sural nerve biopsy specimen revealed a mixed pattern of demyelination and axonal degeneration, the latter being prominent. Gastrocnemius muscle biopsy specimen showed histochemically a mixed pattern of denervation and myopathy with Type II atrophy. It is concluded that cyanide toxicity secondary to laetrile therapy and nutritional deficiency caused the neuromyopathy, as the changes in peripheral nerve are similar to changes described in ataxic polyneuropathy occurring in Nigeria attributed to high cyanide content in the diet and nutritional deficiency. Although this patient received vincristine initially, the development of the neuromyopathy had no temporal relationship to its administration. The clinical profile, as well as peripheral nerve and muscle changes were not similar to either vincristine neuromyopathy or neuromyopathy due to paraneoplastic manifestation of lymphoma. Clinical improvement following discontinuation of "laetrile" by the patient further supports the toxic etiologic results for the neuromyopathy in this patient.

Aged↗
PubMed1982

Intramedullary ganglioneuroma of spinal cord: a clinicopathologic study.

A case of intramedullary ganglioneuroma, a rare tumor occurring in the cervical spinal cord, is presented, and its histologic and ultrastructural features are discussed. In view of the benign course of ganglioneuroma, as represented in this case, it is important to distinguish this tumor histologically from ganglioglioma, a tumor that is histologically similar but has greater malignant potential. The inherent problems in this distinction are discussed. The embryogenesis of ganglioneuroma of the nervous system is also reviewed.

Adult↗
PubMed1982

Clinically asymptomatic pituitary adenoma manifesting as pituitary apoplexy and fatal third-ventricular hemorrhage.

A 56-year-old woman with an asymptomatic pituitary adenoma had a fatal third-ventricular hemorrhage of sudden onset. A suprasellar mass with hemorrhage and rupture into the third ventricle was found at autopsy. Histologically, the tumor cells from the suprasellar mass and the third-ventricular hemorrhage were diagnostic of a pituitary adenoma. The pathogenesis of the third-ventricular hemorrhage from a pituitary adenoma and the need to consider pituitary apoplexy in the differential diagnosis of third-ventricular hemorrhage are discussed. On the basis of a review of the literature, it is felt that computerized tomographic scanning, although most helpful in diagnosis of sellar lesions, does not replace skull radiographs and sellar tomography in the investigation of suspected pituitary apoplexy.

Adenoma↗
PubMed1981

Malignant fibrous histiocytoma of the meninges. Histological, ultrastructural, and immunocytochemical studies.

A case of malignant fibrous histiocytoma arising from the meninges in a 12-year-old boy is reported. This tumor presented as an extracerebral hemorrhagic mass in the left frontal lobe without obvious invasion of the underlying brain. Histologically, a malignant tumor with the characteristic storiform pattern of malignant fibrous histiocytoma with focal areas of hemorrhage was observed. Ultrastructurally, fibroblastic cells, undifferentiated cells, histiocytic-type cells, multinucleated tumor giant cells, and xanthomatous cells were distinctly seen. The possible cell of origin of these meningeal tumors and their prognosis are discussed. The significance of considering this entity in the differential diagnosis of those tumors of the central nervous system with a spindle-cell or xanthomatous component is discussed, and the value of ultrastructural and immunocytochemical study with glial fibrillary acidic protein in the diagnosis is stressed.

Child↗
PubMed1980

Prolactin-secreting pituitary oncocytoma with galactorrhea--amenorrhea syndrome: a histologic, ultrastructural, and immunocytochemical study.

A case is reported of a 24-year-old woman with amenorrhea and galactorrhea and markedly elevated serum prolactin levels who underwent operative resection of a pituitary adenoma. Ultrastructural examination revealed the classic features of an oncocytoma. Immunocytochemical staining was positive for prolactin. Following excision of the tumor, serum prolactin levels returned to normal and the galactorrhea became minimal. This is the first case of a pituitary oncocytoma in which secretion of prolactin was both clinically and immunocytochemically documented.

Adenoma↗
PubMed1979

Primary glioblastoma of the pineal gland.

A 68-year-old woman had Parinaud's syndrome, difficulty in walking, and dementia. A diagnosis of pineal tumor was based on clinical as well as arteriographic and computerized tomography findings. At operation, the tumor was found to be limited to the pineal gland. Histologically, it had the features of a classical glioblastoma.

Aged↗