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Biomedical subjects

U Noster

Publications and source records attributed to U Noster.

14 recordsLinked to original sources
PubMed1978

[Immunofluorescence test in the diagnosis of mushroom worker's lung (author's transl)].

Growing and harvesting a new edible mushroom (Pleurotus florida mushroom--oyster mushroom) liberates a high amount of spores the inhalation of which causes symptoms similar to those of "farmer's lung". The Ouchterlony test detects precipitins against antigens of the spore membrane only in cases with high serum antibody levels, i.e. only one in eight sufferers from the disease had a positive antibody test. Because of this, indirect immunofluorescence was used as a more sensitive method for serum antibody detection: all mushroom workers with clinical symptoms were found to have precipitating antibodies. The test is, therefore, superior to the Ouchterlony one, is simpler and saves time. Furthermore, the immunoglobulin class can easily be obtained at the same time.

Alveolitis, Extrinsic Allergic↗
PubMed1978

[Occupational dermatitis due to a yellow quinophthalone dye (solvent yellow 33: C.I. 47 000)].

An occupational allergic contact dermatitis caused by a yellow quinophthalone dye which is used for colored smokes in detonators was the reason for further studies of this case of allergy. Solvent Yellow 33 (German: Rauchgelb) belongs to the groups of quinaldine dyes which are produced by condensing quinaldine and phthalic anhydride. The dye itself is a mixture of 67% unsubstituted quinophthalone and 33% 6-methylquinophthalone (Colour Index 47 000). Quinophthalone derivatives are widespread in technology and industry and are used as yellow dyes in food (pudding), plastics (PVC), textile goods (nylon) and cosmetics (lipsticks, make-up). Cases of contact sensitization due to quinophthalone dyes are seldom recognized. Sensitizing experiments in guinea pigs were unsuccessful. Therefore Solvent Yellow 33 must be considered a weak sensitizer.

Adult↗
PubMed1977

[Relationship between the skin test and the specific IgE (radio-allergo-sorbens test) in the diagnosis of inhalative allergies].

Immediate-type reactions such as asthma, pollinosis and several forms of urticaria can be regarded as type I reactions according to Coombs and Gell. Primary these diseases are caused by the immune globulin E. As skin testing is accompanied by numerous failors, there is a real possibility in increasing the diagnostic relevance by measurement of the specific IgE in serum (Radio-Allergo-Sorbens-Test = RAST; Phadebas-RAST -- Pharmacia Uppsala). There are often found divergent results and therefore this investigation was started. 1357 RAST-results (530 patients) were compared with skin tests in order to investigate the concordance of the two test-methods. The statistical analysis is performed wit "4-square-Chi2". Very good correspondence could be calculated for the pollens of Festuca elatior, Poa pratensis, horse-epithelium and housedustmite (1 0/00O significancy). 1 0/0 significancy was found for catepithelium and 5 0/0 for Birch-pollen. The advantages and the disadventages of RAST are discussed.

Asthma↗
PubMed1976

[Mushroom worker's lung caused by inhalation of spores of the edible fungus pleurotus Florida ("oyster mushroom") (author's transl)].

A new edible mushroom, known as oyster mushroom (Pleutrotus Florida, variety of Pleurotus ostreatus) has recently gained commercial importance in Europe, having been imported from the U.S.A. in 1963 and cultivated in Germany between 1972 and 1973. Several persons concerned with the cultivation and industrial production of this mushroom fell ill, after close contact with it over a period of some months, with exhaustion, headache, chills and fever, and cough. These symptoms, similar to those of "farmer's lung" were proved to be caused by the spores of Pleurotus Florida, inhaled in harvesting rooms. The suspicion of an allergic disease, is supported by the history and clinical picture, and the demonstration of precipitating antibodies against spore extracts (Ouchterlony test). The antigens probably have a high molecular weight and are fixed to the spore membrane. Experimental sensitisation of rabbits also revealed precipitins. One of three isolated antigens produced antibodies identical in man and rabbit.

Adult↗
PubMed1976

Squaric-acid-diethylester - a strong sensitizer.

A patient developed a circumscribed contact dermatitis after a single contact with squaric-acid-diethylester (SADE). Patch tests with low concentrations of SADE were positive. Based on these observations, experimental studies on the sensitizing capacity of SADE were performed on guinea-pigs. The results disclosed that this compound is a strong sensitizer. Derivatives of SADE, such as the nearly insoluble squaric acid, squaric acid-1,2-diamide and dithio-N,N'-dicyclohexyle-1,2-diamide were not able to produce allergic skin reactions in the sensitized patient nor in guinea pigs. The chemistry and the range of uses of squaric acid and its derivatives are briefly mentioned. A hypothesis on the molecular mechanism of conjugation of SADE to human proteins and thereby on sensitization is discussed. A warning is given for taking precautionary measures before handling this substance.

Animals↗
PubMed1976

Comparison of guinea pig sensitization methods.

Up to now, different methods in guinea pig sensitization were used, to assess contact sensitization potential of low molecular weight chemicals. In order to compare the efficiency of the epicutaneous, intradermal and combined sensitization methods, two stronger sensitizers, the water soluble chlormethylimidazoline hydrochloride (CMI) and the lipid soluble 1,3-dinitrochlorobenzene (DNCB) were used for the experiments. Eleven modified sensitization methods were performed. In a first trial each substance was tested on 10 animals. In a further study those techniques which had produced the best results, that is the highest degree of sensitization, were applied to 25 to 30 animals. For comparison of the results of the various methods, a mean sensitization index was calculated. The best results were achieved with the Maximization Test of Magnusson & Kligman (1969) and the Split Adjuvant Technique of Maguire & Chase (1967).

Administration, Topical↗
PubMed1976

[Influence of a preliminary irradiation once or twice on radioresistance of mice*].

The radioresistance of mice was tested in order to find out in which way it was influence by one or two preliminary irradiations. The thirty-day survival rate after a single total irradiation was taken as a criterion of the radioresistance. Only one test group showed a significant increase of radioresistance after two preliminary irradiations, whereas the resistance of three other groups was reduced remarkably after irradiation doses of 300 resp. 400 R. From these facts we draw the following conclusion: either radiotoxins and the remote effects produced by them are only playing a minor role in NMRI/Han mice or these mice are particular "low-responders" as far as the produciton of antibodies against radiotoxins is concerned.

Animals↗
PubMed1975

[Ulceration of the skin in necrobiosis lipoidica (author's transl)].

As a supplement to earlier investigations, a case of a 46 year old female patient is reported who has suffered from necrobiosis lipoidica granulomatosa with ulceration for 17 years. A marked remission was obtained by treatment with anti-inflammatory and immunosuppressive therapy. It is pointed out that under the usual treatment when ulcers of the lower leg and other areas of the skin do not heal, after exclusion of malignancies, necrobiosis lipoidica diabeticorum or necrobiosis lipoidica granulomatosa must be considered, especially as prophylactic examinations may arise.

Anti-Inflammatory Agents↗