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Biomedical subjects

U Nilsonne

Publications and source records attributed to U Nilsonne.

At least 37 records · Page 2Linked to original sources
PubMed1983

Correlation between lymphocyte-mediated auto-tumor reactivities and clinical course. I. Evaluation of 46 patients with sarcoma.

T-cell-enriched blood lymphocyte populations from 24 osteosarcoma and 22 soft-tissue sarcoma patients were assayed at the time of surgery for proliferative response to, and/or cytotoxic potential against autologous tumor cells. Tumor-free period and survival of the patients were correlated with the results obtained in the in vitro tests. The observation time was between 18 and 118 months (mean 62) for the osteosarcoma patients and between 18 and 72 (mean 42) for the patients with soft-tissue sarcoma. In both groups tumor-free period and survival were longer for those individuals who had auto-tumor reactivity. In the non-reactive group, all patients died within 3 years. Almost all patients had cytotoxicity against K562.

Adolescent↗
PubMed1983

Preoperative radiation therapy of high malignancy grade soft tissue sarcoma. A preliminary investigation.

Twenty-three patients with high malignancy grade soft tissue sarcoma received irradiation (about 40 Gy) followed by surgery. The follow-up time was 62 months or more in all patients. The local recurrence rate was 9 per cent (2/23). One of the patients was reoperated and is living free of disease, giving a local control rate of 95 per cent. Thirty per cent (7/23) of the cases developed distant metastases and died of the disease. Delayed wound healing was observed in 2 cases which was possibly due to the radiation therapy. Since surgery was regarded non-radical in 5 cases, the local control obtained by the combined radiation therapy and surgery is good and should be the subject for further investigations.

Adult↗
PubMed1982

Treatment of osteosarcoma by interferon and differentiated surgery.

Since 1972, all cases of osteosarcoma (48 patients) at the Karolinska Hospital in Stockholm have been treated by leukocyte interferon. It has been administered by intra-muscular injections with a dosage of 3 million standard interferon units daily for one month and thereafter 3 times weekly for a further 17 months. Thirty-two patients were subjected to amputation or disarticulation, but in 16 cases local surgery has been resorted to and the defect after tumour resection has been replaced by autogenous bone grafting or endoprostheses. In 5 of 16 locally treated cases, local recurrence occurred and amputation was performed. Four of the patients later on succumbed from metastases. The selection of cases which can be treated by local resection is difficult. In the present series, the rate of survival was 58% after 5 years. Before 1972 (historical group) the survival rate was 14%. The corresponding - 5 - year survival figure for the contemporary group treated without interferon is 33%. Although the 58% survival rate seems to represent an effect of interferon on osteosarcoma, no statistically significant conclusions can be drawn.

Clinical Trials as Topic↗
PubMed1982

Epidemiology and some prognostic factors in osteosarcoma in Sweden.

Since 1958, there are about 80 cases of primary malignant bone tumours registered each year to the Central Cancer Registry. During the first 10 years, that is 1958--1968, 242 cases of osteosarcoma were registered (28.8% of all bone tumours--22.9% for chondrosarcoma) the incidence should be calculated at 2-3 cases per 1 million a year. The distribution according to age and sex is the same as found in most western countries. In a group of osteosarcoma patients, Dr Broström could study the longitudinal growth from birth until the age of diagnosis and relationship with tooth eruption. It was found that they were statistically identical for the patient and for the controls. An other study demonstrated no difference in the 5-year-survival rate between patients who had an amputation without prior biopsy and those who had a biopsy.

Bone Neoplasms↗
PubMed1982

Adjuvant interferon treatment of human osteosarcoma.

This paper updates the results of the clinical trial to examine the efficacy of exogenous leukocyte interferon therapy as adjuvant treatment for osteosarcoma. So far the incidence of metastases is lower and the survival rate is better for the interferon-treated group than for the concurrent control group. The number of treated patients is too small at present to allow proper statistical calculations to be made.

Clinical Trials as Topic↗
PubMed1982

Function after pelvic tumour resection involving the acetabular ring.

Seven patients subjected to pelvic tumour resection involving the acetabular ring were analyzed with respect to function. In addition to conventional clinical assessment gait was analyzed objectively by means of an electronic walk-way and residual hip-muscle power tested by means of a Cybex II dynamometer. Functional results reported by the patients with respect to pain, walking and working capacity appeared better than those elicited by clinical examination. All patients exhibited a marked pelvic tilt and a positive Trendelenburg sign. Only one patient walked without any kind of support. Leg-length discrepancy was on an average 6 cm. Objective gait analysis disclosed that all patients had reduced weight-bearing time on the operated side as compared to the non-operated. This, however, was clearly less pronounced for those patients who appeared best with respect to pain, walking and working capacity. These patients also showed the best hip extension power which appeared more important from a functional point of view than hip flexion and, surprisingly, hip abduction power. Radiographic examination showed that bony support for the proximal femur, provided either by the formation of a bone shelf from the remaining iliac bone or by the remaining iliac bone itself, was of decisive importance for function. The results of the present study show that pelvic tumour resection involving the acetabular ring, provided radical tumour removal can be achieved, constitutes a feasible alternative to hemipelvectomy from a functional point of view.

Acetabulum↗
PubMed1982

Survival in osteosarcoma in relation to tumor size and location.

To evaluate the outcome for osteosarcoma patients treated with different forms of adjuvant therapy in nonrandomized series, it is important to realize the possible influence of different prognostic factors. In two series of patients with primary classic osteosarcoma, survival was analyzed in relation to tumor size and site. In the first series comprising 57 patients, no adjuvant therapy was given and the five-year survival rate for all patients was 19%. A significantly (p less than 0.01) higher survival rate (43%) was noted for patients with tumors distally located and less than 0 cm in size (as measured by their largest diameter on radiograms), as compared to 12% for patients with larger and proximally located tumors. These figures were the same at three-and five-year follow-up. In the second series, comprising 22 patients, all received adjuvant interferon treatment. The three-year survival rate was 68%, and the five-year survival rate for the 12 patients followed was 58%. The survival rate for patients with tumors distally located and less than 10 cm in size was 88%, as compared to 57% for patients with larger and proximally located tumors. In the interferon series, tumor size appeared more important than location.

Adolescent↗
PubMed1981

[The results of a combination of interferon and selective surgery in the treatment of osteosarcoma (author's transl)].

Since 1971, Interferon has been used by the authors in the treatment of 46 consecutive cases of osteosarcoma. Two thirds of the cases were treated by amputation, the remainder being treated by resection followed by grafting or a prosthesis. No case was treated by radiotherapy or chemotherapy. Before 1971, the survival rate was 15 p. 100; in contemporary cases treated without Interferon, the rate of survival was 30 p. 100. In the present series the rate of survival was 50 p. 100 after 5 years. It is concluded that Interferon seems to have a positive action. The selection of cases which can be treated by local resection is difficult.

Amputation, Surgical↗
PubMed1979

The effect of biopsy on survival of patients with osteosarcoma.

A retrospective study of patients with osteosarcoma was undertaken to determine whether there was a relationship between biopsy and survival. Fifty-seven patients treated at the Karolinska Hospital, Stockholm, between 1938 and 1959 were included in this study, all of whom were less than thirty years old, had a metaphysial osteosarcoma in a long bone but had no pulmonary metastases at the time of diagnosis; all were treated by amputation. No clinical variants of osteosarcoma were included. Twenty-four of the fifty-seven patients had an amputation without a prior biopsy; the others had biopsies before amputation. These two groups were fairly closely matched in age, sex, site and size of tumour, and in the level of amputation; some patients in each group received radiation before operation. Evaluation of these two groups of patients revealed that the performance of a biopsy, with or without a delay of not more than thirty days between the biopsy and the definitive operation, had no adverse effect on survival.

Adolescent↗
PubMed1978

Human tumor-lymphocyte interaction in vitro. III. T lymphocytes in autologous tumor stimulation (ATS).

The T-cell nature of the responding cells in autologous tumor stimulation (ATS) was proven by (1) E-rosette formation of lymphocytes attached to tumor cells during the early period of co-cultivation; (2) blast-transformed E-rosetting cells detectable at the end of the test period (day 6) and (3) the reactivity of T-enriched lymphocyte subset and unresponsiveness of T-depleted fractions. Preparation of tumor suspensions devoid of lymphocytes made it possible to carry out cross-tests between patients. Blastogenesis with allogeneic tumors was rare. The restricted autologous nature of the reaction is a strong indication for genuine tumor-relatedness.

Adenocarcinoma↗
PubMed1978

Contribution to the knowledge of the fine structure of chondrosarcoma of bone. With a note on the localization of alkaline phosphatase and "ATPase".

Seven well differentiated chondrosarcomas of bone have been analyzed by electron microscopy, and the fine structural localization of adenosine triphosphatase and nonspecific alkaline phosphatase has been elucidated. On the basis of the fine structural appearance, two distinct cell types were shown to constitute the tumor tissue: chondrocyte-like cells and large "mitochondria-rich cells". Large, multinucleated cells in the tumor did not seem to correspond to osteoclasts but rather were likely to represent true neoplastic cells. Some chondrocyte-like cells appeared to be binucleated by virtue of deep, groove-like nuclear indentations. Adenosine triphosphatase and alkaline phosphatase were associated with the plasma membrane of both chondrocyte-like and mitochondria-rich cells suggesting that they might be of common origin. Normal chondroblasts and chondrocytes lack histochemically demonstrable adenosine triphosphatase on their plasma membrane. Presence of this enzyme in the tumor cells may indicate that they are histogenetically related to immature non-chondroid matrix forming cells (known to carry the enzymes).

Adenosine Triphosphatases↗
PubMed1976

Search for anti-tumor response in a bone tumor patient with a long clinical history.

Immunological studies are presented on a patient with a long clinical history suggesting the existence of a tumor-specific immune response. His tumor, first considered benign, progressed to a highly malignant osteosarcoma. Cell-mediated immune reactivity against biopsy cells and against tumor extract was detected in vitro by the autologous tumor stimulation test (ATS) and in vivo by the skin test. In one ATS-test with tumor extract, blastogenesis of T-cells was demonstrated. The amount of Ig(s) in consecutive biopsies increased. Biopsies taken in the later period of the disease stimulated only after trypsin treatment. This stimulation was inhibited by autologous serum or acid eluate of the biopsy. The inhibitory factor in the serum was not intact immunoglobin. Blood lymphocytes did not show a discriminatory or disease-related cytotoxicity, either directly or after co-cultivation with the tumor material. Lymphocytes isolated from one biopsy were non-reactive in both the ATS and the cytotoxicity test.

BCG Vaccine↗
PubMed1976

Acute infections in interferon-treated patients with osteosarcoma: preliminary report of a comparative study.

The incidence of acute infections in eight patients with osteosarcoma who are receiving interferon regularly is currently being compared with the incidence among their family members. Observations thus far indicate that the patients treated with interferon are less frequently and less severely ill than their untreated family contacts. The study is continuing, and the patients will also be observed after discontinuation of interferon treatment. Sera are regularly frozen for future viral serologic tests. The preliminary clinical data indicate that therapy with exogenous interferon may afford protection against common acute infections.

Acute Disease↗