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Biomedical subjects

U Neubert

Publications and source records attributed to U Neubert.

At least 73 records · Page 4Linked to original sources
PubMed1982

Susceptibility of Neisseria gonorrhoeae to cefotaxime: in vitro studies and treatment results.

More and more beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae are nowadays isolated in most parts of the world including the European continent. Therefore, there is a need for reliable alternatives in the treatment of gonorrhoea. Cefotaxime--first representative of a new generation of beta-lactamase-resistant cephalosporins--was evaluated for this reason, first in vitro and then in vivo. All 191 strains tested proved susceptible, the highest MIC amounting to 0.03 microgram/ml, a drug concentration well exceeded in plasma for more than 4 h after i.m. application of 0.5 g cefotaxime. In contrast to other investigators we have therefore decided to test this relatively small dose clinically without the addition of probenecid. The clinical results were excellent: 146 of 151 patients (96.7%) were cured. In the female sub-group (34 patients) the cure rate amounted to 100%. Thus, the i.m. injection of 0.5 g cefotaxime as a single dose must be looked upon as a reliable regimen for the cure of uncomplicated gonorrhoea, both in males and females.

Cefotaxime↗
PubMed1982

Antimicrobial effects of an antiperspirant formulation containing aqueous aluminum chloride hexahydrate.

To document deodorant efficacy the antimicrobial activity of a gelatinous antiperspirant formulation of aqueous aluminum chloride hexahydrate was investigated. In vitro assays demonstrated highly bactericidal activity on microorganisms comprising the resident axillary skin flora, including micrococcaceae and aerobic diphtheroid bacteria. Gram-negative bacteria and yeast were partially inhibited. In vivo experiments utilizing occlusive patches on forearm skin and bacterial sampling of the axilla showed pronounced bacteriostasis and persistence of aluminum chloride on the skin. Inhibition of microbial growth lasted more than 3 days after a single treatment of the axilla. Following repeated open applications to the volar aspect of the forearm, the skin remained virtually sterile for 3 days.

Adult↗
PubMed1982

[Sporotrichoid infection caused by Nocardia brasiliensis].

A few days after a spine of one of his indoor cacti had pricked the fourth finger of his left hand, a 56-year-old man developed multiple inflammatory suppurating nodules and infiltrates and a cord-like lymphangitis on the left forearm and upper arm. Nocardia brasiliensis was cultivated from aspirated pus. Subsequently, both Nocardia brasiliensis and Nocardia asteroides were isolated from the cactus earth. This is the first report of an infection by Nocardia brasiliensis acquired in Germany.

Arm↗
PubMed1981

[Sensitivity of Neisseria gonorrhoeae to spectinomycin].

The susceptibility of 408 strains of N. gonorrhoeae to spectinomycin was determined by an agar plate dilution test. The 401 beta-lactamase-negative and 7 beta-lactamase-positive strains were isolated from patients of the Department of Dermatology, University of Munich, in the years 1977 to 1980. The minimum inhibitory concentrations (MIC) ranged from 2 to 32 micrograms/ml. Only one strain was less susceptible with a MIC of 64 micrograms/ml. A comparison between the isolates of 1977/1978 and 1979/1980 showed no decrease in the susceptibility to spectinomycin.

Microbial Sensitivity Tests↗
PubMed1981

[Trachyonychia: 20-nail dystrophy].

Trachyonychia (20-nail dystrophy) is described in four patients with clinical, histological, and scanning electron microscopy techniques. Trachyonychia is a polyetiological symptom: psoriasis vulgaris, lichen planus, alopecia areata, atopic dermatitis, 20-nail dystrophy of childhood, and severe nail dystrophy can all lead to trachyonychia-like nail changes. Nail bed biopsies are necessary for proper diagnosis. In our patients, lichen planus, or psoriasis were excluded clinically and histologically. Spongiotic dermatitis of nail matrix and nail bed with column-like parakeratosis within the nail plate are found in trachyonychia due to alopecia areata, atopic dermatitis, and in its idiopathic form.

Adolescent↗
PubMed1979

[The bacterial flora of preputial space].

The bacterial flora of the preputial space of 210 healthy males (43 children aged between 2 and 11 years, 137 males between 12 and 60 years and 30 men over 60 years) was determined by smears and cultueres from glans penis, sulcus coronarius and the adjacent prepuce. The results were grouped according to various criteria, e.g. glans covered or uncovered and age of males. Differences in the distribution of germs could be found in relationship to age. In the case of an uncovered glans penis the presence of microbial flora corresponds to the grampositive saprophytic bacteria in areas rich in sebaceous glands. In the case of a covered glans the density of microorganisms increases. Prevalent are gramnegative anaerobes, especially Bacterioides melaninogenicus, also enterococci, enterobacteria and coagulase-positive staphylococci.

Corynebacterium↗
PubMed1978

[The diagnostic value of ejaculate cultures in acute unspecific epidiymitis (author's transl)].

Bacteriological cultures of the ejaculates of 28 patients with acute unspecific epididymitis yielded in 6 cases growth of organisms which were considered to be the cause of the disease. Tests with conventional clinical antibiotics showed organism resistance in half of these cases. Because of possible contamination of the ejaculate with organisms in the urethra and in the preputial area, the results of bacteriological cultures of the ejaculate must be evaluated critically. But a bacteriological ejaculate culture should be carried out in all cases of acute epididymitis at the first consultation so that the antibiotic treatment can be begun immediately afterwards with a tetracycline preparation. If the cultures prove to be tetracycline resistant an appropriate antibiotic can then be substituted.

Adult↗
PubMed1978

[Yersiniosis].

A survey was undertaken about bacteriologic, epidemiologic and clinical features of infections caused by Yersinia. Yersinia enterocolitica and Yersinia pseudotuberculosis are gram negative rods of the enterobacteriaceae family. The number of cases of these infections has increased considerably in the past few years. Erythema nodosum often occurs after an enteritic infection by Yersinia. Other skin manifestations are erythema exsudativum multiforme, erythema figuratum and "drug-eruption-like exanthema". Moreover, Yersinia-arthritis may occur. In one particular case a Reiter-syndrome was described. The mechanism whereby Yersinia induce skin lesions is unknown. Prognosis is good. Therapy of choice for infections caused by Yersinia are tetracyclines.

Adult↗
PubMed1978

[Localized dermatitis herpetiformis Duhring of the Cottini type].

Dermatitis herpetiformis Duhring restricted to knees and ellbows is relatively unknown and is called Cottini type. We observed a 23 year old female patient, in whom the resolution of the lesions occured after topical steroids. The dermatitis flared possibly following treatment with an iodine-containing coughing sirup.

Adult↗
PubMed1977

[Unusual picture of a localized argyrosis].

Blue to black patches appeared in the scar of a sectio caesarea performed 30 years ago. Histology and electron microscopy showed a localized argyrosis due to silver suture material used in the operation.

Argyria↗
PubMed1976

[Maceration of the interdigital spaces and gram-negative infection of feet].

The microbiological flora of the macerated skin of the interdigital spaces of the feet of 64 patients were compared to those of 64 other control patients who had normal toe webs. In the control group coagulase-negative staphylococci and aerobic corynebacteria ("diphtheroids") were the most common bacteria found compared to a great number of different organisms including a high percentage of potentially pathogenic bacteria and fungi that were isolated from the macerated toe webs. The clinical appearance was not helpful in suggesting the nature of the causative organism. In order to prevent therapeutical errors bacteriological and mycological cultures are necessary before treatment.

Candida↗