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Biomedical subjects

U N Bhuyan

Publications and source records attributed to U N Bhuyan.

At least 73 records · Page 4Linked to original sources
PubMed1981

Tuberculosis in maintenance haemodialysis patients. Study from an endemic area.

One hundred and fifty patients requiring maintenance haemodialysis were investigated to determine the incidence and pattern of tuberculosis. Twenty patients were found to have tuberculosis, giving an incidence of 13.3 times that of the general population. The most frequent clinical presentations of tuberculosis in these patients were pyrexia, pleural effusion and lymphadenopathy. Diagnostic difficulties were encountered in 7 patients in whom therapeutic trial with anti-tubercular drugs had to be undertaken. Two patients died from tuberculosis. Five patients received renal transplants after initial treatment of tuberculosis.

Adult↗
PubMed1980

Biochemical studies of the isolated rat glomerulus and the effects of puromycin aminonucleoside administration.

Using analytical subcellular fractionation techniques in combination with enzymic microanalysis, studies have been performed on the enzymology and organelle pathology of isolated glomeruli from normal rats and from animals with puromycin aminonucleoside nephrosis. There was a marked decrease in 5'-nucleotidase (plasma membrane) activity 2 days after puromycin aminonucleoside administration. In contrast, catalase (peroxisomes) and N-acetyl-beta-glucosaminidase (lysosomes) showed a significant rise during the first 6 days of treatment. By 10 days most marker enzymes showed a significant decrease in activity. The glomeruli were homogenized in isotonic sucrose and extracts were fractionated by isopycnic centrifugation on linear sucrose gradients in the Beaufay automatic small-volume zonal centrifuge. The properties of the principal organelles were characterized. ed. After 10 days of puromycin aminonucleoside treatment there were no marked differences in the centrifugal properties of these organelles. Morphological correlations with the biochemical changes are discussed and it is suggested that the plasma membrane changes represent the primary site of puromycin aminonucleoside damage.

Acetylglucosaminidase↗
PubMed1978

The effect of undernutrition on immunological responses to BCG and TAB vaccines in mice maintained on a natural diet.

A study was made on the effect of undernutrition on the immunological responses of mice to TAB and BCG vaccines. The mice were fed a diet comprising chapati and germinated grams; one group was fed ad libitum while another was given half the quantity consumed by the first group. The undernourished mice showed a poor immune response to BCG: only 23% showed a positive reaction to foot pad challenge with purified protein derivative, compared with 76% of the well-fed mice. The mean increase in thickness of the foot pad was also significantly smaller in the undernourished mice. Antibody titres against the H and O antigens of TAB were essentially similar in both groups of mice. The results suggest that undernutrition depresses cell-mediated immune responses but not humoral responses.

Animals↗