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Biomedical subjects

U Michel

Publications and source records attributed to U Michel.

61 records · Page 4Linked to original sources
PubMed1986

[Compliance in adjuvant chemotherapy].

The study presented deals with the issue of therapy compliance on the example of female patients with breast carcinoma, who had received adjuvant chemotherapy. Catamnestic results are reported for 44 patients who had answered a complaints questionnaire and participated, additionally, in unstructured interviewing on the problems and strain experienced during and following therapy. The study group consisted of 10 women who had dropped out of treatment, and 34 women who had followed the treatment as scheduled. The physical and emotional strain found are reported, and discussed from the perspective of therapy compliance. Of particular interest in this context is the doctor-patient-relationship, i.e. the question of how the patients' subjective considerations and medical cost-benefit calculations could be heeded in as open and trustful an exchange between doctor and patient as possible.

Adult↗
PubMed1986

[Thermographico-histologic study of the lymph drainage areas in malignant melanoma].

In an investigation including 176 patients with malignant melanoma (MM) of the skin, the preoperative infrared telethermograms (IR-TT) obtained from the draining lymph node area were compared with the clinical and histologic data on lymph nodes removed by dissection. In 19 out of 92 cases with high-risk MM subjected to primary tumor excision and draining lymph node dissection, metastatic involvement of one or more lymph nodes was found histologically. In 18 of 19 cases (= 95%) with metastatic spread of MM, there was a considerable degree of hyperthermic radiation in the respective axillary or inguinal area. On palpation, only 13 of 19 patients (= 68%) showed conspicuous lymph node enlargement. The histologic sections of the lymph nodes of the above 18 patients with both regional spread of MM and hyperthermia were reexamined in order to compare the extent of tumor involvement with the q-classification of IR-TT. There was a remarkable correlation between an increase in the number of macrometastases (and conversely, a drop in the number of micrometastases) and the grades of regional hyperthermia.

Carcinoma in Situ↗
PubMed1985

[Infrared thermography in malignant melanoma. Diagnostic potential and limits].

Using infrared thermography, 264 in patients who were clinically suspected of having primary malignant melanoma (mM) of the skin were examined with regard to the thermographic pattern of both tumor and peritumoral skin area. In 84% of the patients with histologically confirmed mM deviations from normothermic pattern (mainly hyperthermic) were found of the tumor itself and/or the peritumoral area. All nodular mM proved to be hyperthermic. Pigmented skin tumors other than mM (e.g., angioma, basalioma, nevus cells, mole, histiocytoma) predominantly exhibited local isothermia or only minor thermographic changes. The infrared radiation intensity of the mM depended on the individual surface attributes of the tumors. As a rule, the larger mM are warmer than small mM. When comparing histological staging of a mM with thermographic classification, the pT values were strongly correlated with the thermographic values, ranging from Q1 to Q4. The highest measurements of infrared radiation were obtained in the nodular and acrolentiginous mM, as compared to the other melanoma types. There is evidence that mM exhibiting marked local hyperthermia have a particularly to poor prognosis.

Adolescent↗
PubMed1982

[Ulceromutilating acroosteopathy of the feet (author's transl)].

The cutaneo-osseous syndrome of ulceromutilating acroosteopathy, occurring in a rare hereditary and a "symptomatic" form, represents a nosologically clearly defined disease of the forefoot. Main symptoms are painless, deeply penetrating plantar ulcers with hyperkeratotic edges, non-segmental peripheral sensory neuropathy with a more or less dissociated disturbance of sensitivity and pyrexia of the forefoot (or single toes) without typical clinical signs of inflammation. Secondary symptoms, obligatory in therapy-resistant cases, include (almost) non-reactive acroosteolyses of the "neuropathic" type. The disease, increasing potentially in frequency and not recognised sufficiently, can only be treated successfully when pathogenic risk and precipitation factors are abolished selectively. Twenty-five cases could be observed over a period of 11 years with an increasing incidence.

Adult↗