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Biomedical subjects

U Mercati

Publications and source records attributed to U Mercati.

At least 37 records · Page 2Linked to original sources

[Preliminary data on the behavior of the enzyme of metabolism of phospholipid bases in human tumor preparations].

The A.A. have investigated the phospholipids base-exchange enzyme system in the solid tumours in order to state if a correlation between this activity and the variation of the cellular ciclic nucleotides amount was possible considering that these compounds have been reported to undergo a variation in tumour compared with normal tissues. They report some previous results in a lung tumour and in an endometrial carcinoma, were they have found a big increase in the PhS synthesis. Such increase was possible to be seen in the endometrial carcinoma only after a stimulation by 17-beta-estradiol and it was reversed in this case by doxorubicine. These results suggest that an alteration of the PhS synthesis should be one of numerous peculiarity of the neoplastic cell.

Adenocarcinoma↗

[Changes in phosphatidylserine synthesis in human rectal tumors].

We have investigated the phosphatidylserine metabolism in human adenocarcinoma. This phospholipid is involved in the regulation of several enzymic activities of plasma membranes; therefore it could be useful to state if some alteration of tumour membranes propriety depend on variation of phosphatidylserine synthesis. Our results make evident that in such human tumours the phosphatidylserine synthesis is greatly augmented.

Adenocarcinoma↗

[Experience in the treatment of bleeding esophageal varices].

Personal experience with respect to the diagnosis and treatment of bleeding oesophageal varices in patients with cirrhosis is described. Diagnosis is directed both to the establishment of the site of bleeding and the disease responsible and to the evaluation of risk in view of the possibliity of portal decompression. Treatment is aimed at stopping bleeding and at lowering this risk so that as many patients as possible can be operated with an acceptable degree of surgical risk.

Esophageal and Gastric Varices↗

[Late radiological aspects after vagotomy and gastric drainage].

Personal experience in 87 cases of vagotomy and gastric drainage is presented. Pyloroplasty according to Heinecke-Mikulicz was performed in 50 cases and drainage according to Judd in 9. Three groups were distinguished on the basis of the presence of a "gastroduodenal canal" and "pseudodiverticula". Twenty-two patients were subjected to a Finney pyloroplasty, radiologically visible is a transparent line from the large curvature of the antrum to the lesser curvature medially. Jaboulay-Alexiu gastroduodenostomy was performed in 6 cases. Here anastomosis between the large curvature and the second duodenal portion was noted, with preservation of the pylorus. Mention is made of the difficulty of recurrent ulcer diagnosis and the exact interpretation of the appearance of the antrum, pylorus and duodenum after drainage operations of this type.

Duodenal Ulcer↗

[Embolisms of the upper extremities].

6 cases of upper extremity embolism observed over the past three years are reported. Fogarty embolectomy was carried out in all patients, favourable revascularization results being obtained in 5. Forearm amputations was necessary in 1 case owing to the presence of ischaemic lesions that were already advanced at admittance, further proof that results depend above all on the vitality of the extremity rather than on the duration of the arterial occlusion.

Adult↗

[Intrahepatic bilio-jejunal anastomosis].

Personal experience in intrahepatic biliojejunal anastomosis is described, along with the operative tactics and techniques now employed. Stress is laid on the importance of peroperative cholangiography in the division of patients into two groups with respect to drainage of intrahepatic bile, depending on whether or not a wide pathway exists between the two halves of the liver. The strategy to be used for each group is explained.

Aged↗

[Stenosis of the left angle of the colon caused by chronic pancreatitis].

Case of stenosis of the left flexure of the colon caused by pancreatitis is reported. The relevant literature is surveyed and an account is given of the pathogenesis of this forms, and the examinations required in its diagnosis, particularly coloscopy. A preference is expressed for an internal colic derivation (colon-colon anastomosis) rather than resection, on account of the smaller degree of risk involved.

Adult↗

[Use of glucagon in the treatment of acute pancreatitis].

Personal experience with glucagon in 15 cases of acute pancreatitis is reported. Complete remission of pain within 2-3 hr after infusion of the drug was noted in 85% of the series, together with normalisation of blood amylase within 48-72 hr. Glucagon inhibits pancreatic secretio&n. Vairous theories concerning its mechanism of action are examined.

Acute Disease↗