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Biomedical subjects

U Müller

Publications and source records attributed to U Müller.

At least 631 records · Page 35Linked to original sources
PubMed1975

[The significance of the cytochemical adenosine triphosphatase reaction for the diagnosis of benign monoclonal gammopathy (author's transl)].

In 26 cases with benign monoclonal gammopathy the cytochemical activity of the adenosintriphosphatase (ATPase) in the plasmocytes of bone marrow smears was studied. 15 cases showed a decreased and 11 patients showed normal proportions of ATPase positive cells, indicating that the impairment of ATP-ase is non-specific for the diagnosis of multiple myeloma.

Adenosine Triphosphatases↗
PubMed1975

[Drug allergy damage to the blood ].

Drug induced blood dyscrasias, leukocytopenia, thrombocytopenia and hemolytic anemia were observed in 7% of 643 adverse drug reactions registered by drug monitoring in Bern, Switzerland, in the period 1970-1973. Life threatening reactions were consistently more frequent in hematological side effects (22%) than in the total of adverse drug reactions (6%). Blood dyscrasias induced by drug allergy are generally believed to belong to the allergic reactions of type II. Antigen-antibody reaction evolves in connection with cells of the blood, either by fixation of the drug itself or a metabolite on the cell surface, or by adsorption of primarily formed antigen-antibody complexes on the cell. In drug induced immune hemolytic anemia three types may be distinguished: 1. the innocent bystander type, caused by quinine, PAS, rifampicin and others, 2. the penicillin-type, caused by penicillins and cephalosporins, and 3. the autoimmune type caused by alpha-methyl-dopa etc. Agranulocytosis in Europe is most frequently due to pyrazolones, while phenothiazines play the leading role in the USA. In pyrazolone agranulocytosis an allergic pathogenesis is very probable, whereas phenothiazines probably induce agranulocytosis by a direct toxic effect on bone marrow cells. The clinical course in pyrazolone agranulocytosis is acute, whereas it is rather insidious in the phenothiazine type. The main drugs causing allergic thrombocytopenia are thiazide diuretics, quinine, quinidine and sulfonamides. Clinical aspects and therapy of drug induced blood dyscrasias are discussed.

Agranulocytosis↗
PubMed1975

[Cerebral blood flow in rabbits during hypoperfusion of the brain. Flow distribution and methodological problems (author's transl)].

Brains of rabbits were perfused by arterial blood via the internal carotids after ligation of vertebral and external carotid arteries. The effect of the reduction of cerebral perfusion volume on cerebral blood flow was studied by recording the clearance of Krypton-85 from the brains. The clearance curves obtained by recording the gamma radiation of the Krypton-85 represented the sum of tissue clearances from the whole brain (about 10 g) and about 45 g of extracerebral tissue and so were not representative of cerebral or cortical bloow flow. Using external beta-counting the cortical blood flows calculated from the tissue-clearance curves reached mean values of 87 and 159 ml/100 g/min in perfusions with 12 and 18 ml/min respectively. But during reduced cerebral perfusion (2 ml/min) the clearance curves gave cortical blood flow values of 56 ml/100 g/min on the average and so exceeded the values calculated from the perfusion volume (2 ml/min) and the brain-weight (10 g) two to three times. It is concluded that regions of nonperfusion exceeding 50% of the cerebral tissue coexisted with adequately perfused areas. In hypoperfusion the cortical metabolic state was sufficiently correlated with the perfusion volume, but no correlation existed with the cortical blood flow calculated from the clearance curves.

Animals↗
PubMed1975

[Glossopharyngeal neuralgia with cardiac arrhythmias (author's transl)].

In a 68-year-old female patient glossopharyngeal neuralgia of unknown origin occurred accompained by cardiac arrhythmias (bradycardia to asystole) and loss of consciousness. Subcutaneous atropine injections improved bradycardia but did not influence attacks of pain. Complete and permanent freedom from symptoms was established only after treatment with carbamazepine (Tegretal) 200 mg t.d.s.

Aged↗
PubMed1975

Characterization of ineffective erythropoiesis in erythroleukaemia.

In 6 cases initially showing a symptomatology of erythroleukemia, the proliferation of erythroblasts was studied by combined Feulgen cytophotometry and autoradiography after labelling with 3H-TdR in vivo. A proliferation disturbance was observed consisting of an accumulation of diploid and unlabelled cells and a decreased proportion of cells in S. This defect occurred within the basophilic cell compartment in one case and within the early polychromatic cell compartment in all 6 cases. The results indicate the existence of out-of-cycle cells, which may be responsible for the inefficacy for erythropoiesis in this disease. The defect was present in all 4 cases with acute erythroleukaemia. In one of the two cases showing no deterioration of the physical and haematological condition over a period of years, an additional defect was observed, consisting of a striking accumulation of tetraploid unlabelled cells. Therefore, the technique used may be suitable as a diagnostic tool for evaluation of new types of ineffective erythropoiesis.

Aged↗
PubMed1975

Experimental results to immunomesenchymal suppression.

Wet weight of cotton-pellet granuloma and 35SO4-uptake in the acid mucopolysaccharides (AMPS) of granulation tissue of rats and the number of plaque forming cells (PFC) of mice were investigated after the treatment with antilymphocyte globulin, prednisolone, cyclophosphamide and azathioprine. In this way, the effect of these substances could be observed in a mesenchymal reaction and in an immune reaction. The substances are mesenchymosuppressive as well as immunosuppressive, but the present results show that the effective dosage is higher for mesenchymal suppression than for immunosuppression. Antilymphocyte globulin did not cause an alteration of the 35SO4-uptake in AMPS. These experimental findings confirm the clinical experience in the treatment of the so-called autoimmunological diseases which are primary localized in connective tissue. These diseases need a higher dosage of cytostatic substances, glucocorticoids and antilymphocyte globulin in times of acute inflammatory exacerbation than in the chronic phase.

Animals↗