Search PubMed⌕ Search

Biomedical subjects

U Laaser

Publications and source records attributed to U Laaser.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Prevention during adolescence: cardiovascular risk profile in juveniles of Cologne].

6302 adolescents were examined in 1975 for a cardiovascular risk profile ("Cologne Study"). Defined subpopulations could be followed-up prospectively in 1976 and 1980 (participation rates: 76.2%, 81.4%, 66.5%). Both sexes showed a correlation of cigarette smoking and intake of alcoholic beverages. Girls taking contraceptive smoked, drank more and their total cholesterol was significantly higher, and HDL-cholesterol significantly lower as compared to girls without hormonal contraception. A quarter to a third of the total variance for blood pressure, heart rate, total cholesterol, cigarette smoking and body-mass-index can be explained by measurements one resp. four or five years ago. Elevated values in the highest quintile show a clear tendency towards stability of risk status. Considering multifactorial constellations by cluster analysis, three groups with low, medium, and high risk status can be distinguished: 48% of all adolescents maintain their category over 5 years. For children with long-term and manifest elevation of blood pressure a more detailed determination of the risk status is recommended.

Adolescent↗
PubMed1981

[Epidemiology of hypertension risks: of no consequence to the German Federal Republic? (author's transl)].

A widely based epidemiologic research on hypertension has led to successful action programs abroad: e.g. the incidence of hypertension fell by about 50% in North Karelia, Finland, and in the USA the life expectancy rose by 1.5 years. Against the background of international scientific agreement both the Conference for Security and Cooperation in Europe and the World Health Organization have awarded hypertension the highest priority for European cooperation. In the Federal Republic there is a great backlog; the responsible politicians are called upon to set a new course.

Adult↗
PubMed1980

[Kaposi's sarcoma (author's transl)].

Kaposi's sarcoma of the skin and an aplastic syndrome occurred together in a 51-year-old patient. Macroscopically livid papules and nodules were observed. Histomorphologically endotheliomatous cell proliferation with signs of infiltrative growth was found. Because of the aplastic pancytopenia cytostatic treatment of the Kaposi sarcoma was contraindicated. The patient finally died of vascular failure with haemorrhagic diathesis being manifest. Syntropy of Kaposi's sarcoma with malignant haematological diseases is known. However, association with aplastic anaemia has not been observed so far. The pathogenesis of Kaposi's sarcoma is unknown.

Anemia, Aplastic↗
PubMed1980

[Sézary syndrome (author's transl)].

Morphological demonstration of the typical Sézary cell in peripheral blood confirmed the diagnosis of Sézary syndrome in a 64-year-old patient with generalized erythrodermia and typical histopathological skin changes. Enzymes and immunocytological membrane characteristics of Sézary cells changed in the course of the disease after cytostatic therapy. Polychemotherapy clinically led to transitory complete regression of skin changes. Reviewing the few published investigations it is found that the morphologically sufficiently defined Sézary cells are apparently not uniform cytochemically and immunocytologically in different patients.

Autopsy↗
PubMed1980

Sézary syndrome: immunocytological and cytochemical variability of Sézary cells.

The characteristic large cells in the blood of a patient with Sézary syndrome underwent immunocytological and cytochemical changes during polychemotherapy, which caused transient regression of skin lesions. Tartrate-resistant acid phosphatase was demonstrable in a few cells only after chemotherapy; initially, only 2% T cells and 26% B cells could be demonstrated in the blood by immunocytological methods; after cytostatic therapy, 35% T cells but no B cells were detected.

Acid Phosphatase↗
PubMed1979

[Kaposi's sarcoma and aplastic pancytopenia: simultaneous occurrence in a patient].

A 49 year old patient developed simultaneously a histologically verified Kaposi's sarcoma and an idiopathic aplastic pancytopenia. An association of these perhaps virus-induced diseases has not been reported until now. Consequences concerning the diagnostic approach of changes in peripheral blood cells in patients with Kaposi's sarcoma are delineated. Changes in peripheral blood and bone marrow in patients with Kaposi's sarcoma are discussed.

Biopsy↗
PubMed1978

[The importance of changes in whole-body balance of sodium and noradrenaline in essential hypertension (author's transl)].

In 22 patients with essential hypertension plasma levels and urine excretions of sodium and noradrenaline were studied before, during and after long-term beta-blockade with pindolol. The relation between mean blood pressure and the quotient of sodium-/noradrenaline-excretion changed during treatment (placebo r=-0.34; pindolol r=+0.31). During placebo there existed a significant (p is less than 0.03) correlation between blood pressure and sodium-excretion which disappeared during beta-blockade. No correlation between blood pressure and noradrenaline was seen during placebo, whereas during beta-blockade a significant (p is less than 0.003) correlation was observed. In contrast to the placebo period there was a significant positive correlation between sodium- and noradrenaline-excretion during long-term treatment with pindolol. It is concluded that whole-body balance of sodium and noradrenaline is an important factor in essential hypertension.

Adrenergic beta-Antagonists↗
PubMed1978

[A field study with the combination of Pindolol and Clopamid in antihpertensive therapy (author's transl)].

In a field study comprising 678 patients with arterial hypertension efficacy and tolerance of the stable combination VKB 105 consisting of 10 mg Pindolol (Visken) and 5 mg Clopamid (Brinaldix) were investigated. Treatment with 1--2 tablets of VKB per day resulted in a successful therapy in 94% of all patients corresponding on the average to a reduction in blood pressure to 145/85 mm Hg within 14 days. In mean arterial pressures ranging between 120 and 170 mm Hg a positive linear relationship between the individual initial value and the hypotensive effect of the combination could be observed. A controlled omission trial disclosed qualitatively the respective contribution to the effect of the two components Pindolol and Clopamid. With a systematic case control of the serum potassium under the combined therapy with VKB 105 and during a monotherapy with Clopamid and antihypokalaemic effect of Pindolol could be demonstrated diminishing the tendency for potassium loss. The result revealed a far-reaching potassium neutrality of diuresis-depending stimulation of renin by the beta-receptor blocker. In 61 patients altogether subjective side-effects could be recorded, such as vertigo (5%), palpitations (2.8%), fatigue (2%), insomina (1.9%), nausea (1.7%) and vomiting (0.8%). Laboratory controls gave no indication for clinically relevant changes.

Adrenergic beta-Antagonists↗
PubMed1978

Antihypertensive therapy in patients above age 60. Third interim report of the European Working Party on High blood pressure in Elderly (EWPHE).

Three hundred forty nine hypertensive patients above the age of 60 have entered the double-blind multicentre trial of the European Working Party on High blood pressure in the Elderly (EWPHE). After stratification and randomisation half were treated with one or two capsules containing 25 mg hydrochlorothiazide and 50 mg triamterene and if blood pressure control was insufficient methyldopa was added up to 2 g daily; the other half received matching placebo. No significant differences between the groups were present prior to randomisation. A significant blood pressure difference of 25/10 mm Hg was obtained between the groups and maintained during two years of follow-up. No major disturbances in serum potassium or serum sodium were noted with the present drug combination. However, during the initial phase an increase in serum creatinine and serum uric acid was noted in the actively treated group, which was maintained for two years. Also glucose tolerance was impaired after 2 years in the actively treated group. A favourable influence on prognosis by active treatment can be expected on the basis of the blood pressure reduction and in the absence of major electrolytes disturbances. But this benefit must be proven by observed statistical differences in terminating events between the groups. Therefore the patients are being followed for a longer period of time and more patients are admitted into the trial.

Aged↗
PubMed1977

[Risk factors in juveniles. Indications of cardiovascular risk in higher-grade school children of Cologne].

During the last years several studies on the cardiovascular risk-profile of children and adolescents have been started. About 6000 pupils between 15 and 19 years of age have been examined in a cross-sectional investigation in Cologne 1975. One third of them underwent a reexamination in 1976 (80% of the eligible population). The results of the 1975-survey indicate that between 5 and 15% of these adolescents show the following risk-factors in varying combinations: systolic blood pressure above 140 mmHg, cholesterol above 225 mg/100 ml, uric acid above 7 mg/100 ml, smoking of more than 20 cigarettes per day, Broca-weight-index of more than 1,0. The gross partial correlation factors indicate a relatively close association between systolic blood pressure, cholesterol and weight. Some of the risk-factors in adolescents can probably be traced throughout longer periods, thus systolic blood pressure was measured repeatedly in high categories for the same individuals (with a predicitve value of about 50%). The Cologne-study is to be continued for high risk-groups as a long-time-follow-up study.

Adolescent↗