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Biomedical subjects

U Kunze

Publications and source records attributed to U Kunze.

At least 37 records · Page 2Linked to original sources
PubMed1998

[European Medical Association Smoking or Health (EMASH)--consensus on smoking cessation: guidelines for physicians].

The present study summarizes the latest scientific findings on smoking cessation and the various therapeutic possibilities. The guidelines presented here were compiled by the experts of EMASH (European Medical Association Smoking or Health). Accurate diagnosis and adequate treatment of nicotine dependence is essential for achieving sustained abstinence. Diagnostic procedures including the Fagerström Test for Nicotine Dependence (FTND) and various modes of nicotine replacement therapy (chewing gum, plaster, nasal spray and inhaler) are described. New symptoms of nicotine dependence (nocturnal sleep disturbing nicotine craving, nicotine pre-abstinence syndrome), that permit a more precise diagnosis, are discussed.

Europe↗
PubMed1998

[Vienna standard in diagnosis of nicotine dependence: Vienna Standard Smoking Inventory].

The Standard Vienna Smokers' Inventory (VSSI) ("Wiener Standard Raucher-Inventar" [WSR]) is based on the authors' experience and was designed to optimize primary and additional diagnostic procedures associated with smoking cessation treatment. The aim of this inventory is to enable therapists interested in smoking cessation interventions to initiate diagnostic procedures as well as to use efficient therapeutic modalities. The study also highlights those areas of the patient's history which should be given special attention and the theoretical background of these areas. The various comprehensive sections of the WSR include general data pertaining to the patient's life, the basic situation (basic rate), especially with regard to nicotine dependence, pre-abstinence syndrome and "tar" exposition values, follow-up of smoking habits, earlier attempts to give up smoking, and possible barriers to cessation of smoking--such as insufficient motivation, "nocturnal sleep disturbing nicotine craving" or carbohydrate dependence. Furthermore, previous illnesses, pre-existing risk factors and regular intake of drugs are also discussed. Finally, the study emphasizes that the WSR should be used by the therapist according to his/her level of training and experience, thus providing the possibility to use specific, individual approaches to deal with specific individuals and situations.

Adult↗
PubMed1998

Self-reported prevalence of venous diseases in the general population of Austria--results of the SERMO (Self-Reported Morbidity) Study.

Venous diseases are common in Western societies, their causes, however, have remained largely unknown. The prevalence of venous diseases in the general population of Austria was assessed, and information on the background morbidity of venous diseases obtained from the data base of the SERMO study (Self-Reported Morbidity Study). The SERMO study consists of 9 representative population surveys conducted between December 1994 and December 1995; the study aimed at describing and monitoring the characteristics of background morbidity in the Austrian population. 5.9% of the sample reported to suffer from venous diseases (vein varicosis, phlebitis, vein thrombosis) in 1995; the point prevalence was 4.1%. The prevalence rate of chronic vascular disorders of the lower extremities was 5.9%. The prevalence of venous diseases is much higher among women than men. Advanced age is as much a risk factor for venous diseases as is low education. This study has shown that persons suffering from venous diseases, especially those advanced in age, suffer more often from concomitant diseases and disorders than others. In addition to clinical and mortality data, self-reported morbidity data provide important information on the health of a general population. Persons above 60 years of age are expected to constitute one third of the entire Austrian population by the year 2030. With this anticipated demographic development in view, the need for long-term prevention plans of chronic venous diseases appears to be of particular importance.

Adolescent↗
PubMed1998

[Obesity in Austria: epidemiologic and social medicine aspects].

The importance of overweight not only for individual health and life expectancy but also for resulting health economics is stressed considering data from Austria. Epidemiology of overweight in Austria shows 8.5% of the population to be morbidly obese (Body Mass Index [BMI] higher than 30) and 14.5% overweight (BMI between 27 and 29.9). Prevalence of overweight in Austria shows a very masked decrease from eastern to the western districts of the country. As in other countries correlation of overweight with cardiovascular risk factors (cholesterol, triglycerides, glucose and systolic blood pressure) was found to be highly significant also in Austrian health screening programs. As far as treatment of overweight and its prevention is concerned not only short term weight loss, but it maintenance is important. Not only a realistic change in feeding behaviour and dieting but also a change in life style including regular physical activity is recommended requiring repeated and long-term controlling by qualified persons of the health profession.

Adult↗
PubMed1997

[Diagnosis and therapy of nicotine dependence].

The 1988 Report of the US-Surgeon General states very clearly, that the use of tobacco products is not a matter of free choice, but is the result of an addiction as scientifically valid as the addiction to heroin and other narcotics. Using the Fagerström Test for Nicotine Dependence (FTND) to assess nicotine dependence in a population 6,000 randomly selected Austrians were interviewed. 42% of men and 27% of women were found to be smokers. 3 groups of smokers differing in dependence can be described: 36.5% are nicotine addicted; 30.2% must be psychosocial dependent because they show nearly no sign of nicotine dependence; and there is a group between. The scientific literature provides informations on many methods and techniques for a smoking cessation, both pharmacological approaches have been tried to treat nicotine dependence in man. According to scientific standards and many controlled studies, nicotine has been the only drug found to be effective in treating nicotine dependence. Many techniques, ranging from self help to sophisticated combined therapeutic approaches including pharmacological interventions, are now available to deal with the nicotine addiction.

Adolescent↗
PubMed1997

Childhood cancer mortality in Austria, 1980-1992.

This paper is the first to describe trend analyses focusing on cancer mortality among children (aged 0-14) in Austria covering the period 1980-1992. The data used for analysis were abstracted from the official Austrian mortality statistics of the years 1980-1992. Because of the poor reliability of cancer registry data in Austria in the past, the study is based on mortality date only. The reliability of the mortality data is positively related to a high autopsy rate in Austria. Statistical standardization is based on the European standard population. In the period 1980-1992 cancer was the cause of death of 718 children. Leukaemia was responsible for 34.5% of all childhood cancer deaths and 1.5% of all childhood deaths. The mortality of all malignant neoplasms in children decreased significantly (p = 0.0004) from 54.8 per million in 1980 to 33.9 per million in 1992. This trend is mainly due to the reduction in mortality of leukaemia, which has decreased from 22.3 per million in 1980 to 13.1 per million in 1992 (p = 0.0003). The age group 0-4 years experienced the highest overall cancer mortality (46.7 per million). The decreasing trends are primarily caused by better diagnostic and therapeutic procedures and most probably not by decreasing incidence. Due to the small number of cases this positive effect can only be demonstrated in leukaemia mortality, but not for other cancer sites.

Adolescent↗
PubMed1997

[Health monitor (SERMO study)--concept, methodology and a paradigmatic result on subjective morbidity in headache].

In Austria, microcensus surveys on self-reported morbidity are carried out at regular intervals every ten years, generally by the Federal Statistic Centre. In the following, we describe an epidemiological observational service which could be regarded as an additional public health instrument. This service is termed "health monitor", and the SERMO (self-reported morbidity) study is the scientific project associated with it. The "health monitor" data provide information on the prevalence of various illnesses and impairment, characteristics and variables of background morbidity by repeated short-term representative surveys on self-reported morbidity. The health monitor permits continual observation of the background morbidity of an entire population, while scientific questions pertaining to the SERMO study can be investigated via the health monitor data base. Self-reported morbidity data provide important information about the health of a general population, in addition to clinical and mortality data, and help to make decisions in health policy. By collecting informations (e.g. nearly every month) on background morbidity, "health monitor" and SERMO project could complement other Austrian public health systems to measure the overall health of the population in general.

Adolescent↗
PubMed1996

The human insulin analog insulin lispro improves insulin binding on circulating monocytes of intensively treated insulin-dependent diabetes mellitus patients.

The rapidly absorbed analog of human insulin, insulin lispro (LP), is characterized by a faster onset of action, a higher peak insulin level, and a shorter duration of action compared with regular insulin (RI). The aim of this study was to investigate whether intensified treatment with either LP or RI influences insulin receptor status. Twelve patients with insulin-dependent diabetes mellitus (IDDM) participating in a multicenter randomized cross-over trial were allocated to this study. Four patients began with LP, whereas eight patients started with RI. Each patient was switched to the other insulin after a 3-month treatment period. Competitive [125I]A-14-insulin binding studies were performed with isolated monocytes. Treatment with insulin lispro increased the total number of insulin binding sites from 9,400 +/- 2,200 (RI) to 20,300 +/- 3,000 (LP)/monocyte (P < 0.001). The insulin concentration required for a 50% competition of [125I]insulin binding (IC50) decreased from 0.6 +/- 0.2 (RI) to 0.1 +/- 0.03 (LP) nmol/L, indicating significantly higher affinity of insulin binding sites during LP treatment (P < 0.001). In additional experiments, the time course of insulin binding was determined after an oral meal. In LP-treated IDDM patients, the affinity and capacity of insulin binding showed a nadir 1 h after insulin injection and a regained binding affinity and capacity 5 h later. These changes observed after LP treatment were comparable to the effect of endogenous insulin secretion in healthy control subjects. In contrast, the IDDM patients who injected RI showed a decreasing insulin binding affinity and capacity, most markedly expressed after 5 h. The corresponding serum levels of insulin were inversely correlated with the affinity and capacity of insulin-binding sites. Pretreatment of cultured human IM-9 lymphoblasts with LP or RI yielded no difference in the down-regulation of insulin binding. In summary, intensified conventional insulin therapy with LP increased the number and affinity of insulin receptors on circulating monocytes to a level similar to that observed in healthy subjects. We conclude that the improved insulin receptor status observed during LP treatment is caused by its more physiological pharmacokinetic profile.

Adult↗
PubMed1995

[Blood pressure awareness in Austria: indicators of an increasing information deficit].

Attitudes and knowledge of the Austrian population concerning hypertension have been investigated on a regular basis for 15 years (1978-1993). In 1978 a public campaign of information on hypertension was conducted all over Austria. Between 1978 and 1993 four representative population surveys, based on random samples, were performed (1978, 1984, 1990, 1993). The four surveys showed that maximal blood pressure awareness after the campaign was followed by a decrease of awareness between 1984 and 1993. Above all, lack of knowledge of personal blood pressure increased markedly over the observation period. The determinant "don't know my blood pressure" was self reported by 10% in 1978, 7% in 1984, rising to 17% and 18% in 1990 and 1993, respectively. This increase was significant in females and males younger than 50 years. Nearly no differences were found in self-reported high blood pressure and antihypertensive drug intake between 1978 and 1993 (1978, 1984, 1990: 14%, 1993: 12% with respect to the former; 1978: 10%, 1990: 11%, 1993: 8% with respect to the latter). In 1993 significantly less people than in 1978 reported that their blood pressure had been measured within the past three months (1978: 49%; 1993: 34%). People estimated overweight, alcohol, mental stress, and cigarette smoking as the most important risk factors for hypertension (89%, 89%, 88%, 83%, respectively). The importance of these risk factors in the eyes of the questioned population increased between 1978 and 1993, significantly in the case of cigarette smoking. Primarily a lack of information was found in knowledge of personal values, whereas knowledge of risk factors for hypertension was considerably higher. The results of the four surveys lead to the conclusion that the population should be informed about the health hazards of high blood pressure more intensively and people should be motivated to take an interest in their blood pressure.

Adolescent↗