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Biomedical subjects

U Koch

Publications and source records attributed to U Koch.

At least 181 records · Page 10Linked to original sources
PubMed1977

[Eustachian tube function and middle ear pressure with adhesive tympanic membrane (author's transl)].

The function of the Eustachian tube and the corresponding middle ear pressure are significant factors in the etiology of adhesive ear drums as well as in the prognosis of a possible tympanoplasty. In 58 patients with adhesive tympanic membrane tubal function and middle ear pressure were determined by means of the air pressure equalization technique respectively by direct punction. Normal or only slightly impaired tubal function as well as the middle ear pressure was found in one third of the cases, whereas in the majority of the patients an impaired tubal function and underpressure in the middle ear was registrated. As a precondition for a successful tympanoplasty the ventilation of the middle ear must be improved in these cases. At present this is achieved by a polyethylene tube inserted in the tympanic membrane during the operation.

Ear Diseases↗
PubMed1977

[Ultrasound diagnosis in simulated middle-ear-effusions in isolated human temporal bones (author's transl)].

By means of simulated middle-ear effusions in isolated human temporal bones it could be demonstrated, that ultrasonic echos of the drum show typical patterns if the middle-ear is filled with fluid or not. In normal air-filled drums there is only the echo of the tympanic membrane, whereas in fluid-filled drums a second echo from the bony medial wall of the tympanon appears. --A method is described how to perform ultrasonograms under visual observation of the tympanic membrane.

Ear Diseases↗
PubMed1977

[Primary intratympanic meningioma (author's transl)].

A primary intratympanic meningioma is reported, which was histologically verified. 1 1/2 and 2 1/2 years after surgical removal, there were no signs of recurrence, neither clinically nor histologically. Sites of origin of the primary intratympanic meningiomas are discussed. Symptoms, diagnostics, differential diagnosis, therapy and prognosis are summarized in relation to nine cases of the literature.

Ear Neoplasms↗
PubMed1977

[Middle ear pressure after rhinoplasty surgery (author's transl)].

Middle ear pressure after rhinoplasty surgery was determined by tympanometry. Measurings were done in 94 patients (total of 177 ears) before the rhinoplasty operation and during the following 6 days respectively in special cases up to three weeks. In 153 ears normal middle ear pressure was found before the operation. After the rhinoplasty in about 2/3 of all cases negative pressure up to 300 mm Ws developed. This negative pressure was equalized in the vast majority of cases (84.3%) after the tamponade was removed. In some cases negative pressure persisted for 6 days after the operation (9.8%); in few cases (5.9%) up to three weeks. In 13 out of 24 patients having negative middle ear pressures together with rhinomanometrically objectified impaired nasal ventilation rhinoplasty led to normal middle ear pressure. Reasons for the development of negative pressures in the middle ear are discussed. The results of the investigations lead to consequences concerning tympanoplasty in connection with rhinoplasty operations. Rhinoplasty and tympanoplasty should not be performed on the same day--there should be an intervall of 4--6 days between these operations. Negative pressure in the middle ear in cases of impaired nasal ventilation can be improved by rhinoplasty.

Airway Obstruction↗
PubMed1977

Cell-kinetical analyses of squamous cell carcinomas of the oral region and the effect of a combined therapy of 5 fluorouracil and irradiation. A contribution to the discussion about tumorcell-synchronization.

Out of 180 incubations of human biopsies 33 were from patients with malignant tumors of the oral region. In 9 cases it was possible to analyse the cell cycle of the tumor cells with the double labeling in vitro method (3H and 14C-thymidine). Histologically the tumors were keratinizing squamous cell carcinomas with high labeling indices. The generation time of the tumor cells ranged from 20 to 130 hours. The length of the DNA synthesis phase varied between 7.3 and 17.9 hours. With the knowledge of the cell-kinetic data the patients received an infusion of 5 Fluorouracil throughout the length or parts of the calculated G 1 phase. At the end of the 5 FU infusion there was a constant two-hour pause and after the duration of the calculated DNA synthesis phase the tumors were irradiated with 150 rd per session. The treatment was repeated until a total dose of 6000 rd was achieved. Under the combined therapy of 5 FU and irradiation the inoperable keratinizing highly differentiated squamous cell carcinomas regressed extraordinarily fast. The patients were free of pain after a very short time. No vital tumor tissue was visible in control biopsies. Some patients remained without any tumor recurrence now more than 2 years after onset of therapy. In the discussion it is stressed that the reason for the successful treatment of highly differentiated squamous cell carcinomas with 5 Fluorouracil and subsequent irradiation is not easily explained, because recent experimental findings and impulsecytophotometrical studies on human biopsy material suggest that both the synergistic action of thecytostatic drug and the irradiation as well as an altered recruitment of the tumor cells are responsible for the clinical success rather than a synchronisation effect.

Adult↗
PubMed1975

[T-groups: development, participation and goals].

An attempt is made to explain the position of training groups in our society from the analysis of their development. Doing this we consider the social and economical causes of the origin and rapid growth of the T-group movement. The social structure and the motivation of the trainees are discussed, and finally, the possibility of achieving individual and social changes by training groups is examined.

Germany, West↗
PubMed1975

[Postoperative estimation of stapes- and tympanoplastics by pressure evoked threshold shift (author's transl)].

Postoperative middle ear function (tympano-and stapesplastics) is discussed by threshold shift caused by pressure evoked dislocation of the middle ear transmission system (tympano audiometry). The hearing ability in correlation with the tympanogram und tympano-audiogram of special cases out of a total of 91 patients is shown. Different types of tympano-and stapes plastics are discussed.

Audiometry↗