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Biomedical subjects

U Kellner

Publications and source records attributed to U Kellner.

98 records · Page 6Linked to original sources
PubMed1990

[AC and DC electroretinography in degenerative retinal diseases].

In clinical electrophysiology AC-recorded ERGs are used for the investigation of a- and b-wave parameters. The direct coupled (DC-ERG) ist used to record the c-wave. Theoretically the DC-ERG technique has less influence on the recorded potentials than the AC-ERG technique. We recorded AC- and DC-ERGs of 20 normal eyes, 17 eyes with x-linked congenital retinoschisis and 30 eyes with retinal degenerations. In normal eyes no difference was found between AC- und DC-ERG concerning a- and b-wave amplitudes, latencies and implicit times, the b/a-ratios and the oscillatory potentials. The 30 Hz flicker amplitude was higher in the DC-ERG (p less than 0.0003). The intraindividual variability of all measured parameters was comparable between AC- and DC-ERG. In x-linked retinoschisis the b-wave amplitudes and the b/a-ratios were lower in the DC-ERG than in the AC-ERG. In retinal degenerative diseases the a-wave amplitudes were higher and the dark-adapted b-wave amplitudes lower in the DC-ERG, therefore the b/a-ratio was lower in the DC-ERG. We conclude, the DC-ERG is a reproducible method for clinical routine investigations. It is comparable to the conventional AC-ERG technique. In certain diseases the pathological features of the electroretinogram were more distinct in the DC-ERG than the AC-ERG.

Adolescent↗
PubMed1990

[X-chromosomal congenital retinoschisis. Clinical aspects and electrophysiology].

We evaluated retrospectively the clinical records and electrophysiological results of 52 patients suffering from X-linked congenital retinoschisis. Characteristic clinical findings were hyperopia (mean +2.3 +/- 3.1 D), reduced visual acuity (mean 0.24 +/- 0.2) and always macular pathology. Peripheral retinoschisis was present in 53% of the eyes. The natural course of the disease was normally stable. Complications were visual loss in 9.3%, vitreous hemorrhages in 4.7% and retinal detachments in 10.7% of the eyes. These complications generally occurred within the first decennium. Prophylactic laser coagulation was of no use because it was complicated by retinal detachment in 43% of our series. The electrooculogram was usually normal. In addition to the known electroretinographic findings of a low normal a-wave and reduced b-wave amplitudes, we found prolonged b-wave latencies and implicit times.

Adolescent↗
PubMed1989

[Acute psychosis caused by poisoning with cyclopentolate].

The authors report on a 17-year-old female patient who suffered an acute psychotic attack after local application of cyclopentolate 1.0% in both eyes. The literature is reviewed with regard to systemic side effects of local application of cyclopentolate. Toxicity of cyclopentolate may be found in every age group even if tolerated without side effects before and it has no specificity for patients with certain (especially brain) diseases. The rapid short-term cycloplegic effect and the rare cases of systemic toxicity support the authors opinion that cyclopentolate is a very useful and well-tolerated diagnostic substance.

Adolescent↗
PubMed1988

Effect of intravitreal liquid silicone on optic nerve function.

We recorded visual-evoked cortical potentials before and after pars plana vitrectomy and intravitreal liquid silicone filling in 30 patients (30 eyes) with complicated retinal detachments without vascular eye disease or glaucoma. The flash- and flicker-evoked cortical potentials increased in amplitude in all cases. Of 21 eyes followed up for more than 50 days, eight had a 30-Hz flicker response before and after surgery. Of 13 eyes with preoperatively reduced flicker-frequency responses, ten (77%) were improved after surgery. The visual-evoked cortical potential parameters did not deteriorate in any of the patients. We concluded that no toxic effect of intravitreal liquid silicone on the optic nerve could be shown by electrophysiologic methods.

Cerebral Cortex↗
PubMedDate not supplied

Refined mapping of the gene encoding the p127 kDa UV-damaged DNA-binding protein (DDB1) within 11q12-q13.1 and its exclusion in Best's vitelliform macular dystrophy.

Best's vitelliform macular dystrophy (Best's disease) is an autosomal dominant disorder of unknown causes and is typically characterised by an accumulation of lipofuscin-like material in the subretinal space of the macula. The disease gene has been localised to chromosome 11q12-13.1 within a 1.4 Mbp interval flanked by markers at D11S1765 and uteroglobin (UGB). Here we report the refined mapping of the gene encoding the p127 kDa subunit (DDB1) of a UV damage-specific DNA binding protein within the D11S1765-UGB region. Northern blot analysis demonstrates an abundant expression of the DDB1 transcript in the retina suggesting a functional role for DDB1 in this tissue. These considerations together with the chromosomal localisation have led us to evaluate the possible involvement of DDB1 in the pathogenesis of Best's disease.

Base Sequence↗