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Biomedical subjects

U K Abbott

Publications and source records attributed to U K Abbott.

At least 37 records · Page 2Linked to original sources
PubMed1977

Scoliosis in chickens.

Scoliosis developed in 55 per cent of sexually mature birds (68 per cent of male and 46 per cent of female birds) in a highly inbred line of chickens originally produced from white Leghorns. The curve could first be detected at five to six weeks of age and progressed until spontaneous fusion of the thoracic vertebrae occurred. Studies of these chickens indicated that abnormalities of growth and development of the spine are not the primary cause of the scoliosis. Preliminary studies of the paravertebral musculature also indicated that simple muscle imbalance is not responsible for the curve. Initial studies of collagen extracted from the scoliotic line of chickens showed it to be more soluble than similar collagen extracted from white Leghorn controls.

Animals↗
PubMed1975

Limb development in diplopodia4: a polydactylous mutation in the chicken.

In a study of the polydactylous mutation of the domestic chicken, diplopodia4, we have found that the genetic lesion affects primarily the mesoderm and only secondarily the ectoderm. The effect of this mutant mesenchyme on overlying ectodermal ridge, either mutant or normal, is to thicken the ridge preaxially, leading to increased outgrowth and preaxial polydactylism. A "zone of polarizing activity" in the normal limb-bud seems to have a role in the control of its anteroposterior polarity. We have examined diplopodia4 limb-buds for polarizing activity and found it to be normal in its activity and distribution. These results suggest that the supernumerary outgrowth in the mutant limbs result from increased ridge mainon of the polarizing zone.

Alleles↗
PubMed1972

Inductive interactions between human dermis and chick chorionic epithelium.

In a study of specificity in mesenchymal-epithelial interactions, human embryonic dermis has been recombined with chick chorionic epithelium and cultured for 7 days on a host chick chorioallantoic membrane. Dermis from the sole of the foot or palm of the hand induces chick chorionic epithelium to form an epidermis that resembles chick rather than human epidermis. Chick epithelium, though it has the capacity to respond to a human dermal stimulus, is limited to forming chick-type tissue. The human dermis was modified in its turn by culture in combination with chick epithelium.

Animals↗