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Biomedical subjects

U Jensen

Publications and source records attributed to U Jensen.

24 records · Page 2Linked to original sources
PubMed1986

[Work of breathing in spontaneous respiration with continuous positive airway pressure].

In postoperative respiratory failure continuous positive airway pressure (CPAP), besides improving pulmonary gas exchange, influences respiratory mechanics. Elastic and flowresistive components of respiratory work were measured in intensive care patients being weaned from the respirator. Measured values during breathing with a continuous-flow CPAP system with elastic reservoir were compared with those for O2 breathing via T-tube. Under CPAP total breathing work and resistance were reduced. Compliance, tidal volume and respiratory frequency did not change significantly. The reduction in respiratory work was primarily due to decreased nonelastic work associated with a decrease in resistance. Thus, on weaning from mechanical ventilation using a reservoir-CPAP system, the respiratory work was reduced in comparison to O2 breathing via T-tube.

Airway Resistance↗
PubMed1986

[Thiopental kinetics in high-dose use].

The kinetics of thiopentone when administered in high doses were investigated in two patients with elevated intracranial pressure and three patients with focal cerebral ischemia. Initial saturation of the tissues is best achieved by a series of infusions with decreasing infusion rate. Administration of a bolus followed by maintenance doses proved unsuitable. The course of concentration under maintenance dosage was extremely variable, mainly due to interindividual and intraindividual variations in clearance. The apparent distribution volumes in these patients (1.38-3.10 l/kg, mean 2.43 l/kg) corresponded to the volumes determined after bolus administration. The total body clearance was low (45.8-103.4 ml/min, mean 72.3 ml/min) and was the reason for long elimination half-times (15.6-25.0 h, mean 23.2 h). Four patients biotransformed thiopentone regardless of the concentration. In one female patient the biotransforming enzyme systems may have been saturated. While conversion of thiopentone to pentobarbitone is generally only of secondary importance, an unusually high plasma pentobarbitone concentration was observed in one patient, reaching 50% of the concentration of the original substance. On the average, thiopentone was 75-80% proteinbound. The binding rate changed considerably with time. It could not be shown that this was influenced by albumin concentration between 25 and 50 g/l. The thiopentone concentration in the ventricular fluid corresponded approximately to that in the plasma fluid. Owing to the variability of the total body clearance and plasma protein binding, and the possibility of changes in tolerance, thiopentone administration must be controlled individually according to the EEG and intracranial pressure. Monitoring of the drug concentration in plasma is recommended.

Adult↗
PubMed1983

Metabolism of phosphate and calcium after severe accidental trauma.

Hypophosphatemia is a common finding during the first 4-5 days after severe accidental trauma. We demonstrated that hypophosphatemia after trauma is caused by a definite decrease in renal phosphate threshold (TmPO4/GFR), that is the theoretical plasma phosphate concentration at which all of the filtered phosphate is reabsorbed by the renal tubules and renal excretion of phosphate is close to zero. We speculated that the decrease in renal phosphate threshold could be due to an increased activity of PTH which in turn could be the result of ionized hypocalcemia. In 7 patients with severe and in 8 patients with moderate trauma, however, we found ionized calcium and PTH levels to be within normal limits. Total plasma calcium was below normal (1.90-2.00 mmol/l) up to 20 days after trauma, probably due to a decreased plasma albumin concentration (25-30 g/l). We conclude, that ionized hypocalcemia and consecutive stimulation of PTH is not the cause of decreased renal phosphate threshold after severe accidental trauma.

Adolescent↗
PubMed1982

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH)--treatment with lithium.

Two patients with SIADH after brain trauma are described. Features of SIADH are "inappropriate" antidiuresis and excessive natriuresis with negative sodium balance resulting in hyponatremia and plasma hypoosmolality which may lead to cerebral dysfunction. Oral lithium carbonate was beneficial in both patients. With plasma levels of lithium around 1 mmol/l a temporary impairment of renal concentrating ability and antinatriuresis with normalization of plasma sodium and plasma osmolality was observed. The SIADH subsided about 4 months after the original trauma, long after gross neurological symptoms had resolved.

Accidents, Traffic↗