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Biomedical subjects

U Goldbourt

Publications and source records attributed to U Goldbourt.

At least 163 records · Page 9Linked to original sources
PubMed1977

Differences in cardiovascular morbidity and mortality between previously known and newly diagnosed adult diabetics.

498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermittent claudication were considerably greater in both groups of diabetics than in non-diabetics. The frequency of hypertension and left ventricular hypertrophy was about the same in both groups, and in non-diabetics. -However, the pattern of increased morbidity for angina pectoris and the increased rate of sudden death is seen only in the previously diagnosed diabetics. Different pathological mechanisms might be responsible for angina pectoris and sudden death, as compared to myocardial infarction and these might be related in diabetics to the duration and severity of the disease.

Adult↗
PubMed1977

Characteristics of smokers, non-smokers and ex-smokers among 10,000 adult males inIsrael. II. Physiologic, biochemical and genetic characteristics.

Physiologic, biochemical and genetic characteristcs of current smokers, non-smokers and ex-smokers were compared among a study population of almost 10,000 working men aged 40-65 years in Israel. Many significant differences were found, although most differences were small. Current and ex-smokers were slightly taller than non-smokers, and height was correlated to amount smoked. Current smokers had lower weights (absolute and adjusted)8 skunfolds, systolic and distolic blood pressures, and uric acid levels, but had higher pulse rates and higher concentrations of total and beta-cholesterol, hemoglobuin and hematocrit. They showes, however, lower alpha-cholesterol (absolute and relative) concentrations. All the above differences were dose-response-related but discriminant analysis incorporating socio-demographic and behavioral correlates revealed only a moderate degree of combined discrimination. The conclusion is that, while cigarette smokers differ from non-smokers in many ways, the overall difference is umimpressive. This explains why, in prospective analysis, increased mortality and morbidity among smokers could not be attributed to confounding variables. Ex-smokers resembled current smokers in height and cholesterol but were closer to non-smokers levels of weight, skinfolds, blood pressure, uric acid and alpha-cholesterol. Ex-smokers also had inermediate levels of hemoglobin and hematocrit. Cigar and pipe smokers differed from non-smokers only in their elevated levels of cholesterol and uric acid. There was no variation by smoking habits among blood groups of seven types. It is concluded that an overall similarity exists between different smoking groups mainly in terms of coronary risk factors, and that therefore, constitutional differences do no account for the increased mortality and morbidity among smokers.

Adult↗
PubMed1976

Angina pectoris among 10,000 men. II. Psychosocial and other risk factors as evidenced by a multivariate analysis of a five year incidence study.

The major independent role played by anxiety and severe psychosocial problems (especially family ones) is demonstrated by this multivariate analysis of a five year prospective study of the development of new angina pectoris among almost 10,000 adult men (average annual incidence = 5.7/1,000). The independent effect of these two variables is considerably augmented by the other significant risk factors of age, total serum cholesterol, systolic or diastolic blood pressure, certain electrocardiographic abnormalities and diabetes mellitus. The presence of all seven risk factors (at a high level) increases the probability of angina pectoris developing within five years to 289/1,000 from 14/1,000, when these factors are low or absent. The wife's love and support is an important balancing factor, which apparently reduces the risk of angina pectoris even in the presence of high risk factors. The implications of these findings to the pathophysiology and prevention of angina are stressed.

Adult↗
PubMed1976

Diabetes, prediabetes and uricaemia.

Three diabetes surveys carried out at two yearly intervals on 10000 men aged 40 years and over have enabled us to compare four groups of subjects with regard to their serum uric acid level in relation to carbohydrate metabolism. Prediabetics, that is, persons who screened negative at previous surveys and subsequently developed diabetes, had a higher mean uric acid level than normals (p less than 0.001). Their uric acid level was considerably higher than in diabetics, who had a mean value lower than normals (up to p less than 0.001). Men, without diabetes, but having an abnormal GTT were found to have a mean value higher than the normals at each survey.

Adult↗
PubMed1976

Unrecognized myocardial infarction: five-year incidence, mortality, and risk factors.

In the course of 5 years, 9509 healthy adult subjects had an average annual incidence of 3.6 unrecognized infarcts per 1000 persons and 5.3 clinical ones per 1000 persons. A multivariate analysis showed that the most significant risk factors were age, left axis deviation, left ventricular hypertrophy, cigarette smoking, systolic or diastolic blood pressure, and peripheral vascular disease. Some of the known risk factors of clinical infarct, or angina pectoris or both, such as cholesterol, diabetes, anxiety, and psychosocial problems, do not play a significant role in unrecognized infarcts. Subjects whose electrocardiograms were initially interpreted by cardiologists as noninfarcts but by the computer as infarcts developed a high rate of unrecognized infarcts in the subsequent 5 years. A 7-year mortality follow-up showed a markedly higher rate among the unrecognized infarct group as compared with the noninfarct population, but significantly lower than those who developed a clinical infarct.

Adult↗
PubMed1975

Major factors in the development of diabetes mellitus in 10,000 men.

The average annual incidence of diabetes among 8,688 adult men followed up for five years was 8.0/1,000 with Asian, African and Israeli-born having higher rates than European-born. Multivariate analysis of the findings suggested the following: the most significant variables associated with the development of diabetes are overweight and peripheral vascular disease; the high incidence of diabetes in immigrants from Asia and Africa might be an example of Neel's "thrifty genotype" or failure of adaptation to relatively rapid environmental changes; serum cholesterol level, blood pressure, uric acid level, and education were important also; and the probability of developing diabetes within five years rises from 17/1,000 (when the major variables are low or absent) to 450/1,000 (when they are high and present). This has important clinical implications.

Adaptation, Physiological↗
PubMed1975

Ischemic heart disease and pulmonary ventilatory function.

The results of spirometric examinations on 4, 331 Israeli male civil service employees, aged 45 years or more, were analyzed according to the presence or absence of certain aspects of ischemic heart disease. Vital capacity was lower in individuals with a previously history of a heart attack, in those with definite or suspected angina pectoris and in those with ECG evidence of myocardial ischemia, probable or possible myocardial infarction, left bundle branch block or nonspecific T wave changes in subjects without these findings. The differences were small, but statistically significant. Vital capacity was lower in subjects with a recent history of a heart attack (within three years) than in those whose heart attack had occurred more than three years prior to the examination. The ratio of forced expiratory volume in the first second to forced vital capacity was not significantly different between individuals with or without a past history of heart attack, angina pectoris or ECG evidence of coronary heart disease.

Angina Pectoris↗
PubMed1975

Characteristics of smokers, nonsmokers and ex-smokers among 10,000 adult males in Israel. I. Distribution of selected sociodemographic and behavioral variables and the prevalence of disease.

Sociodemographic and behavioral characteristics of nonsmokers and smokers were compared in a large sample of working men aged 40 to 65 years. The prevalence of several diseases was compared. There was a significantly higher percentage of smokers among those born in the Middle East (outside Israel) and North Africa. Smokers were characterized by crowded housing (a high number of persons per room); low levels of education; little leisure-time physical activity; and a tendency to be nonreligious. Current cigarette smoking gradually decreased with age, while smoking a cigar or pipe only, increased. The demographic and behavioral profile of current smokers in general, and of "heavy" (larger than or equal to 21 cigarettes/day) smokers in particular, resembled that of those who had smoked at any time. Both the current and the "heavy" smokers were more often later immigrants to Israel, had more children, and were physically active at work, frequently being engaged in manual labor or technical work. Prevalence of myocardial infarction, angina pectoris, definite peripheral arterial disease, intermittent claudication and peptic ulcer was significantly higher among those who had smoked at any time. Apart from silent myocardial infarction and intermittent claudication, subjects with these conditions also included a significantly higher percentage of former smokers. Former smoking was also related to age, number of years in the country, less crowding at home, low activity at work, and a low calorie intake (particularly of protein and carbohydrates).

Activities of Daily Living↗