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Biomedical subjects

U Gaspard

Publications and source records attributed to U Gaspard.

At least 109 records · Page 6Linked to original sources
PubMed1977

Comparison of histological changes seen in placental tissue cultures and in placentae obtained after fetal death.

The histological changes in placental tissue cultures were observed and compared with those seen in placentae obtained after intrauterine fetal death. Early damage of the syncytiotrophoblast and improvement in the appearance of cytotrophoblast were seen in both cases. It is suggested that it is the cessation of the fetal circulation which causes these changes.

Culture Techniques↗
PubMed1977

Thyroliberin and gonadoliberin tests during pregnancy and the puerperium.

Highly specific and sensitive radioimmunoassays for HTSH, HFSH and HLH have been used in order to investigate pituitary thyrotrophic and gonadotrophic functions of pregnant and puerperal women. The radioimmunoassay system for HFSH, using reagents prepared in our laboratory, is described. Thirty-three women were studied during pregnancy and post-partum. Forty-one TRH tests were performed. Basal levels of TSH, and increase in serum TSH after intravenous injection of TRH were similar in pregnant and puerperal women and in a control group. Thirty-three LH-RH tests were also performed. Basal levels of LH and FSH remained undetectable throughout pregnancy and in early puerperium. Furthermore, after intravenous injection of LH-RH neither LH nor FSH activity could be detected. It has thus been demonstrated that pituitary responsiveness to TRH during pregnancy and the puerperium is similar to that of non-pregnant young women. In contrast, a complete cessation of pituitary gonadotrophic functions is observed during the same period.

Adolescent↗
PubMed1977

[Alpha fetoprotein in maternal blood during normal and pathological pregnancies].

AFP was assayed in serum of normal pregnant women and in patients with pathological pregnancy. Pathological levels of AFP, defined as increased or decreased concentrations compared with the normal distribution, was detected in 83.5 % of pregnant women who delivered a dysmature child and in 88 % of those whose placenta was macroscopically sclerous. A longitudinal determination of AFP appears to be useful in the follow-up of risk of abortion.

Estriol↗
PubMed1976

Prolactin levels during the menstrual cycle.

The levels of prolactin, FSH, LH, oestradiol and progesterone were measured daily during fourteen ovulatory cycles. The behaviour of FSH, LH, oestradiol and progesterone was classical. Non-systematic changes occurred in prolactin levels during the course of the menstrual cycle with the highest level being either during the ovulatory period or during the luteal phase. However, the mean level of prolactin was significantly higher during the ovulatory and luteal phases than during the follicular phase. A direct relationship between oestradiol and prolactin levels was noted, although there was no correlation between prolactin on the one hand and FSH, LH and progesterone on the other.

Adult↗
PubMed1975

Plasma glucagon levels in normal women during pregnancy.

Increased plasma pancreatic glucagon concentrations have been reported during various states of decreased glucose tolerance. In vitro studies have demonstrated that human somatomammotropin stimulates glucagon release. The present investigation aimed at evaluating the role of plasma flucagon in the insulin resistance associated with normal pregnancy. Postprandial samples of plasma were obtained from 156 pregnant women between the 5th and the 40th week of pregnancy and were assayed for blood glucose, plasma insulin, glucagon and free fatty acids. Plasma insulin showed a gradual increase during pregnancy, and reached its maximal values during the last trimester. A moderate but significant increase in plasma glucagon was present between the 16th and the 28th week of gestation, whereas during the first and the last trimester of pregnancy its concentration was similar to that in non pregnant women. Intravenous glucose tolerance was performed during the last trimester and in a group of non pregnant control women. The slight decrease in glucose tolerance and the marked hyperinsulinemia associated with late pregnancy were accompanied by a more rapid and more pronounced decrease in plasma glucagon. A rapid and sustained decrease in glucagon was also observed when plasma FFA were raised by the intravenous administration of a triglyceride emulsion and heparin. These data suggest that glucagon is not involved in the insulin resistance associated with normal human pregnancy.

Adult↗
PubMed1975

[Release of neurophysins during suckling in the lactating woman].

Using radioimmunoassay for total immunoreactive blood neurophysins (I.R.Neur.) we demonstrate a significant increase 30' after the onset of suckling in 26 normal carefully studied lactating women. On the first day postpartum a constant increase is only observed in 12 patients whilst a significant increase is clearly shown for all patients from the 2nd to the 6th day. These variations are similar to those observed for prolactin blood levels; there is however no relation between basal, suckling stimulated, or ergocryptin inhibited prolactin blood level on the one hand and I.R.Neur. blood level on the other hand.

Exocytosis↗
PubMed1975

[Radioimmunologic assay of alpha-fetoprotein in various normal and pathological conditions].

AFP can be measured by radioimmunoassay in 52 hours using an incubation at 18 degrees C for 48 hours and the double antibody solid phase method to separate the free labelled AFP from the labelled AFP bound to the antibodies. In these conditions, the sensitivity and precision of the assay are very satisfactory and the results are directly in correlation with the results obtained using the classical double antibody method. In the serum of normal people, except pregnant women, the concentration of AFP is not detectable or is less than 20 ng/ml. In the serum of pregnant women, AFP increases from the 8th. week of gestation to the 32nd., then stabilises or gradually decreases.

Carcinoembryonic Antigen↗