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Biomedical subjects

U F Haustein

Publications and source records attributed to U F Haustein.

At least 253 records · Page 14Linked to original sources
PubMed1979

[The Sézary syndrome--an erythrodermic T-cell-lymphoma].

Report on a 75-year-old patient with Sézary syndrome which is characterized by the following leading symptoms: Erythrodermia, leukocytosis, circulating atypical lymphocytes with cerebriformous nuclei (Sézary cells) and swollen lymph nodes. Light microscopic and electron microscopic findings refer to a transitory situation of the Sézary cells from the reactive character to the (pre)neoplastic one. The disease is classified by T-(helper)cells as a low grade non-Hodgkin-lymphoma in parallel to mycosis fungoides and in general it finishes lethally after a course of 5 to 8 years. Apart from local steroid ointments and UV-irradiations the internal application of steroids, in the late stage if necessary in combination with cytostatics is recommended for therapy.

Aged↗
PubMed1979

[The Langerhans cell--its macrophages-analogous function in the triggering of the allergic contact eczema (author's transl)].

1. Langerhans cells represent specific granula-containing dendritic cells which do not have desmosomes, tonofilaments and (pre)melanosomes and which therefore appear as clear cells in the epithelial tissue. 2. They occur in the squamous epithelium, and also in the corium, lymph node and thymus. They account for 1-1,7% of the whole volumen of the epidermis. 3. They do not represent effete melanocytes, but they originate from the mesenchym. Their migration from the dermis into the epidermis, their identity with histiocytosis X cells, their surface receptors as well as function underline the mesenchymal origin. 4. Probably the Langerhans cells regulate the mitosis and differentiation of the keratinocytes. 5. The antigen-presenting and lymphocyte stimulating functions of Langerhans cells as effector cells in allergic contact eczema are proved. They are able to phagocytize antigens (haptens), to apposite lymphozytes, to proliferate after the challenge by antigens as well as to migrate through the lymph vessels into the regional lymph nodes. 6. At their surface they bear receptors for Fc-IgG and C3 as well as Ia-antigens as immune response genes of the major histocompatibility complex (MHC). 7. With regard to point 5 and 6 they have the same properties as the macrophages. 8. Langerhans cells are damaged and destroyed, respectively, by immune complexes after activation of the complement pathway as well as by killer T-lymphocytes. Thus they are regulated as target cells by humoral and cellular mechanisms. 9. The allergic inflammatory reaction is triggered by mediator substances (of lysosomal origin?) which are liberated by the destruction of the Langerhans cells as well as by lymphokines. The preferently suprabasal occurrence of the Langerhans cells explains the early beginning of the edema and spongiosis as well as their localization in the lower layers of the epidermis. 10. The macrophages-analogous and antigen-presenting functions, which are genetically regulated are essential for the sensitization in allergic contact eczema. The ability to stimulate allogenic T-Lymphocytes in the mixed lymphocyte reaction might be of particular importance for the skin transplantation.

Complement C3↗
PubMed1979

[On the suitability of migration inhibition techniques in the in-vitro-diagnostics of chromium allergy (author's transl)].

1. Under the conditions of cell culture potassium dichromate is reduced to trivalent chromium (diphenylcarbacid/fotometry). Trivalent chromium reacts with proteins more strongly than the hexavalent chromium (gelchromatography/atom absorption spectrophotometry) and presumably represents the actual hapten. 2. Because of this in-vitro-conjugation chromium salts are suitable in their unconjugated form for applying in migration inhibition tests (capillary/Clausen technique). 3. In migration inhibition tests potassium dichromate showed a better antigenicity than chromium chloride. The capillary method was more sensitive than the Clausen technique when using the same test concentration. 4. Correlations between the degree of the patch test and the value of the migration inhibition did not exist.

Allergens↗
PubMed1979

[Detection of intercellularsubstance-autoantibodies after antigen-antibody-complex splitting in pemphigus foliaceus (author's transl)].

One patient suffering from pemphigus foliaceus exhibited the typical intercellular deposits of immunoglobulins in the subcorneal layers of the affected and not affected skin by direct be detected by means of several antigensubstrates. They could only be found after splitting of the antigen-antibodies-complexes. The laboratory findings exclude a more distinct deviation of the humoral and cellular immune reactivity.

Antigen-Antibody Complex↗
PubMed1979

[Impetigo herpetiformis and PUVA-treatment (author's transl)].

Report on a 20 years old pregnant woman, who fulfilled the criteria of the impetigo herpetiformis as well as later those of the pustular psoriasis Zumbusch in her clinical course. The impetigo herpetiformis is interpreted as a variant of the pustular psoriasis occurring during the pregnancy with lowered calcium-level, which increases the endogeneous eruption pressure. After negative attempts of treatment with Prednisolon, antibiotics, and later with Methotrexat an excellent therapeutic effect could be achieved by oral PUVA-treatment.

Administration, Oral↗
PubMed1978

[Veneral diseases today].

The venereal diseases gonorrhoe and syphilis showed again in GDR an increasing tendency concerning their frequency by the year 1974, after having reached a low point about 1967. Now they occur relatively constantly. This increase observed throughout the world is caused by acceleration, changes in sexual behavior, homosexuality, increased promiscuity, tourism and other factors. Numerous false diagnoses of syphilitic symptoms such as herpes simplex, balanitis, carcinoma of the penis, angina, haemorrhoides, anal fissure, drug eruption and others cause the delay in the diagnostics and false treatments. Penicillin represents the drug of choice nowadays. Strict registration orders, intensification of the interdisciplinary cooperation, strict investigation of the infectious sources and endangered contact persons as well as enlarged health and sexual education are suitable weapons in the fight against the spreading of the venereal diseases.

Diagnostic Errors↗
PubMed1978

[Sclerosing of varicose veins in general practice].

The great number of patients suffering from varicosis and its complications urgently requires an active therapy. This treatment simultaneously represents a prophylaxis against the development of thrombophlebitis, thrombosis, leg ulcers and hypostatic congestion dermatoses. The varicosclerosation is not bound to instrumental preliminary examinations and therefore feasable without great efforts in the outpatient department. After testing the patency of the deep veins and taking into consideration the indications and contraindications the varicosclerosation achieves good results and is nearly free from side-effects. The percentage of relapses is caused by the constitutional weakness of the connective tissue and must be taken into account from the very beginning. General practitioners and specialists of internal medicine should make use of this method, since dermatologists and surgeons alone are not able to cover the quantitative demand.

Humans↗
PubMed1978

Detection of antibodies after immune complex splitting in serum of patients with bullous pemphigoid and systemic lupus erythematosus.

No free anti-basement membrane antibodies were found in the sera of four patients with bullous pemphigoid, and no free anti-DNA antibodies in the sera of two patients with systemic lupus erythematosus. The sera treated with 3 mol/l urea and by gel chromatography to separate these antibodies from any circulating complexes, and antibodies to basement membrane were detected by immunofluorescence and to DNA by the Farr technique. The appropriate antibodies were found in all the sera, indicating that failure to detect antibodies by routine procedures may be due to binding of the antibodies to soluble antigens forming complexes in the sera.

Antibodies↗