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Biomedical subjects

U Engelmann

Publications and source records attributed to U Engelmann.

At least 145 records · Page 8Linked to original sources

The Mainz pouch (mixed augmentation ileum and cecum) for bladder augmentation and continent diversion.

The surgical technique for construction of the Mainz (mixed augmentation ileum and cecum) ileocecal pouch for bladder augmentation or continent urinary diversion focuses on 3 functional features: creation of a low pressure reservoir of adequate capacity from cecum and 2 ileal loops, which are split open longitudinally, antirefluxing ureteral implantation into cecum or ascending colon, achieved by a standard submucosal tunnel technique, and in cases of bladder augmentation continence depends on competence of the bladder neck and urethral closure mechanisms, while in urinary diversion continent closure of the pouch is achieved by isoperistaltic ileoileal intussusception or implantation of an alloplastic stomal prosthesis. Of 11 patients with Mainz pouch bladder augmentation (5 of which were undiversions) 10 are completely dry day and night with normal intervals of bladder evacuation. Two patients with myelomeningocele are on intermittent catheterization for bladder evacuation, while the remainder void spontaneously without significant residual urine. Of 12 patients with Mainz pouch urinary diversion 6 have an ileoileal intussusception valve and are completely continent, as are 3 of 4 with an alloplastic stomal prosthesis. Two patients still are awaiting implantation of a sphinteric prosthesis.

Adolescent↗

The Mainz pouch (mixed augmentation ileum 'n zecum) for bladder augmentation and continent urinary diversion.

A new technique for fashioning an ileocecal pouch, applicable for both bladder augmentation and continent urinary diversion, is described. A low pressure reservoir is achieved by antimesenteric longitudinal transsection of ileum and cecum and formation of a pouch from the cecum and two ileal loops. The antireflux procedure consists of submucosal tunnel implantation of the ureters into the cecum. Clinical application of the operative technique in 4 cases for bladder augmentation and in another 6 cases for urinary diversion has proven the validity of our functional concept: all patients with Mainz pouch bladder augmentation are completely dry day and night with normal intervals of bladder evacuation. Of the 6 patients with Mainz pouch urinary diversion, 2 rely on a an all alloplastic stomal prosthesis for continence, another 2 have achieved continence with isoperistaltic ileo-ileal invagination, and the remainder are awaiting implantation of a sphincteric device.

Adult↗

[Heart valve replacement with myocardial revascularization].

Coexisting coronary artery insufficiency includes risks to patients with valvular heart disease, thus complicating management. In 15 patients requiring aortic or mitral valve replacement preoperative coronary angiography demonstrated severe coronary stenoses which were treated by bypass grafts with valve surgery. These combined operations turned out to be safe and effective.

Adult↗

[Differential diagnosis of palpable changes in scrotal content. Specificity and sensitivity of high resolution B-scan sonography].

In 96 patients in urological treatment the 10 MHz high resolution B-scan sonography proved to be a valuable complement to inspection, palpation and diaphanoscopy. A distinction between testicular, extratesticular, cystic and solid lesions could be made with great reliability. Masked testicular neoplasia associated with hydroceles testis and epididymitis can be detected earlier with sonography. However, great care must be taken when differentiating benign from malign changes in the testicles and epididymis. Testicular neoplasia, focal orchitis, testicular abscess and chronically inflamed tumours of the epididymis have a similarly lowered echogenicity and a tumour-like picture. Focal areas of increased testicular echogenicity in all cases represented benign calcifications, fibrosis or cicatricial tissue. Operative exploration is obligatory when the dignity of the lesion is unclear.

Diagnosis, Differential↗

Digital subtraction angiography in staging renal cell carcinoma: comparison with computerized tomography and histopathology.

Digital subtraction angiography was compared to computerized tomography and histopathological findings for staging renal cell carcinoma in 24 patients. Injection of contrast material through a 16 gauge angiocatheter into the femoral vein provided digital subtraction cavography, digital subtraction arteriography and excretory urography during 1 investigation. Computerized tomography established the diagnosis in all patients, while digital subtraction angiography showed all angiographic signs of renal cell carcinoma in 14 (58 per cent). T staging was correct on computerized tomography in 18 patients and on digital subtraction angiography in 16. Absence or presence of venous involvement was indicated correctly by computerized tomography in 20 patients and by digital subtraction angiography in 21. In small tumors the combination of ultrasonography, digital subtraction angiography and excretory urography is sufficient for an operation. In all other tumors digital subtraction angiography cannot replace computerized tomography but adds useful information about arterial distribution, possible venous tumor thrombus and the anatomical relationship of vessels.

Angiography↗

[The effect of cisplatin on the healing of intestinal anastomosis in the rat. Microangiography and light microscopy studies].

The influence of a single dose cisplatin on wound healing of enterostomies in rats was investigated by measurement of the wound-breaking strength, microangiographically and histologically. Cisplatin (5 mg/kg body weight) was given on day-1 or day-5 preoperatively. Cisplatin led to a significant reduction of the wound-breaking strength, mostly marked on day +14 after operation. The reasons are: a reduced induction of connective tissue proliferation; an inhibition of proliferation of fibroblasts and endothelial cells, and a retardation of vessel proliferation.

Animals↗

[Accuracy of computer tomography in urinary bladder cancer. Study of 74 patients following radical cystectomy].

The accuracy of computed tomography in staging bladder carcinoma has been investigated in 74 patients who underwent cystectomy (n = 70) and pelvic lymphadenectomy (n = 74). The results of the initial CT findings (prospective analysis) and the results of reviewing all CT scans retrospectively by 3 investigators have been compared. Retrospectively, T-staging was correct in 64%, overstaging was seen in 26% and understaging in 10%. N-staging was correct in 99% (n = 73/74) and obstruction of the upper urinary tract with dilatation of the ureter could be diagnosed in every case. The differences between retrospective and prospective analysis are discussed. Staging errors are seen in patients with tumor infiltration of the prostate or the uterus, with microscopic invasion of the perivesical fat, after irradiation of the pelvis or previous surgery. Metastatic involvement of lymph nodes below 1.5 cm diameter cannot be recognized.

Adolescent↗

Permeability of the rat bladder to Cisplatinum under different conditions: comparison with Mitomycin C and Adriamycin.

In 50 female Sprague-Dawley rats the absorption of Cisplatinum through the bladder wall was studied. Under different conditions, including cystitis and electrocoagulation of the bladder mucosa, the absorption was low and the measureable serum concentrations did not exceed 2.64 micrograms/ml. The influence of Tween 80--a non-ionic surfactant--on the absorption is investigated. The results are compared with those found for Adriamycin and Mitomycin C under identical conditions.

Animals↗

Adriamycin permeability of the rat bladder under different conditions.

Fifty female Sprague-Dawley rats were treated with 1.4 or 2.4 mg. adriamycin intravesically. Radioimmunological measurement of serum concentrations were performed up to 3 hours post-instillation in normal bladder mucosa, cystitis, and after electrocoagulation, under different filling conditions, as well as with the use of a detergent (Tween 80). The serum concentrations achieved were markedly higher after electrocoagulation or cystitis; altogether they reached only 1/6,000 of the instilled concentration. These studies on the rat bladder suggest that perioperative instillation of adriamycin to prevent recurrence is not contraindicated shortly before or after transurethral resection (TUR) of superficial bladder tumors.

Absorption↗

[Computed tomography of renal angiomyolipomas].

22 cases of angiomyolipoma were studied by computerized tomography. Characteristics of the tumours were density values less than -25 HU in 21 patients; one patient having tuberous sclerosis showed higher attenuation values. In 6 of 22 patients angiomyolipomas were associated with tuberous sclerosis. Two large tumours presented with spontaneous rupture and massive retroperitoneal hemorrhage. CT findings are sufficiently typical for angiomyolipomas and therefore suitable for distinguishing the benign lesion from renal cell carcinoma.

Adolescent↗

Influence of cis-platinum on healing of enterostomies in the rat.

The influence of cis-platinum on the wound healing of bowel anastomoses was studied in 104 male Sprague-Dawley rats. After a single preoperative doses of 5 mg/kg body weight, the wound-breaking strength (WBS) was tested with a material tester on the 4th, 7th, 14th and 28th day postoperatively. The WBS was significantly lower in treated animals as compared to the untreated controls. The reasons for this are discussed in comparison with other cytotoxic agents. Before cis-platinum can be used as adjuvant chemotherapy to cystectomy, which is frequently combined with an ileum or colon conduit procedure, further investigations on the operative side effects of cis-platinum on bowel anastomoses are necessary.

Animals↗

Experimental investigations on the absorption of intravesically instilled mitomycin C in the urinary bladder of the rat.

After ligation of ureters and urethra, male Sprague-Dawley rats were treated over 3 h with either 2 mg mitomycin C (MMC) intravesically (group I), or in conjunction with pre-instillation bladder electrocoagulation (group II) or iatrogenic Escherichia coli/xylene-induced severe cystitis (group III). Vesical absorption of MMC was investigated by measuring serum MMC up to 180 min postinstillation on the basis of a thin agar plate method. There was no statistically significant different with regard to the total amount of MMC absorbed between groups I and II. However, when groups I and III or II and III were compared, a significant differing transvesical absorption was calculated, being higher for the electrocoagulation than for the cystitis group. The possible clinical implication of this finding is discussed in connection with the most recent literature.

Absorption↗

Ferritin - another tumor marker for testicular malignancies.

On the basis of results obtained with other malignancies, the usefulness of serum ferritin as a tumor marker in the diagnosis of testicular tumors was studied. In 68 patients with malignant testicular tumors and 22 patients with benign testicular processes, serial determinations of beta-human chorionic gonadotropin (beta-HCG), alpha-fetoprotein (AFP) and serum ferritin were performed. The serum ferritin values showed no relationship to tumor stage, and no difference in nonseminomatous and seminomatous tumors. In particular, no diagnostic improvement was achieved in those cases in which the conventional markers AFP and beta-HCG were unsuccessful (falsely negative results). Furthermore, serum ferritin values were influenced by hepatic factors and anemia, so that serum ferritin - on the basis of the present material-could not be considered a useful tumor marker in testicular malignancies. Further studies on the determination of carcinofetal isoferritin and other new tumor markers are warranted.

Adolescent↗