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Biomedical subjects

U D Koenig

Publications and source records attributed to U D Koenig.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Humoral immune response--cervical cancer patients: lymphocytotoxic antibodies (author's transl)].

Sera of 120 cervical cancer patients as well as that of 116 healthy control persons were screened for lymphocytotoxic antibodies using microlymphocytotoxic tests variated in temperature and incubation time. In 76 of 120 cancer-sera (63.3%) lymphocytotoxic antibodies could be detected in comparison with 26 sera of 116 controls (22.4%); p less than 0.0005. With the differentiation into the stages of the disease the highest percentage of lymphocytotoxic antibodies was found in patients with stage 0 of cervical cancer. The presence of lymphocytotoxic antibodies in sera of cervical cancer patients suggest the possibility that this disease is an allotransplant as well as expression of an autoimmune process.

Antilymphocyte Serum↗
PubMed1978

[Cervix carcinoma as an immunological model. Part 2. In vitro studies and HLA system typing].

Carcinoma of the cervix uteri is one of the most important tumors in women. The tumor induces an immunological defense reaction against itself in the tumor host. The round cell infiltrate at the tumor invasion line, which predominantly consists of small lymphocytes is the morphological equivalent of this interrelationship. In the lymph-nodes of the drainage area of the tumor certain patterns of reaction can be differentiated, which may be interpreted as humoral or cellular immune reactions. Cellular immune reactions in lymph-nodes of patients operated according to the method of Wertheim-Meigs were correlated with a better prognosis of the tumor disease. The hypothesis of an involvement of the HSV-type II in the genesis of the cervical carcinoma is supported by the increased incidence of antibodies against the virus. Therewith, relations between the stage of disease and the age of the patient were found as a possible basis for the virus hypothesis and the immune reaction to the tumor associated antigens an altered genetic situation may be presumed. Typing in the HLA-system demonstrates an accumulation of the frequency of the antigen B12 in patients with carcinoma of the cervix. These investigations may lead to a differentiated outlook with regard to the detection of risk groups and therapeutical consequences for cervical cancer.

Antibodies, Viral↗
PubMed1978

[Anaesthesia and immunology (author's transl)].

There is evidence of immunosuppressive influence of trauma/operation and anesthesia. The human immunological system is outlined as a complex functioning apparatus with humoral and cellular factors. The influence of operation and/or anesthesia on immunocompetence has been demonstrated by animal studies, in vitro examinations and clinical investigations. The analysis of these results and their significance for an impairment of the immunological surveillance of the patient is tried to be elucidated. There should be payed attention to the clinical consequences, especially in patients on high risk.

Anesthesia↗
PubMed1977

[HL-A polymorphism and its relation to cervix neoplasms].

Twenty-three HLA antigens were investigated in 121 patients with clinical cancer as well as 188 male and 212 female controls. Patients with cervical carcinoma showed significant differences in some HLA frequencies from that of controls. Patients with cervical carcinoma showed significant differences in some HLA frequencies from that of controls. In the localized form of the neophasia HLA-A3 was decreased, HLA-A9 and B 12 were increased. In the disseminated form of cervical carcinoma HLA-A 1 were found decreased and AW 32 and B 12 increased. HLA antigens could be factors, together with others yet unknown, i.e. immune response genes, HSV-2-infection, which produce an increased susceptibility to the disease.

Antibody Formation↗
PubMed1977

[Cold-lymphocytotoxic antibodies in the sera of cervix-carcinoma patients].

Sera of 120 patients with cervical cancer were screened for cold reacting, complement dependant autolympho-cytotoxins (CoCoCy). These antibodies occurred in 21,7% of the patients in comparison with 11,2% of 116 controls. The highest percentage of CoCoCy-antibodies was detected in the sera of patients with cervical cancer stage I (27,6%). Thus demonstration of CoCoCy-antibodies may be of pathogenetic rather than of diagnostic interest. CoCoCy-antibodies could be seen to reflect autoimmune reactions in cervical cancer.

Autoantibodies↗
PubMed1977

[The importance of herpes simplex virus type 2 (HSV-2) infection pregnancy and the period following birth (author's transl)].

The Type 2 herpes simplex virus is mainly localized in the genital region and is transmitted by sexual intercourse. A distinction must be made between primary and recurrent infection. During pregnancy, infection of the generative tract with HSV-2 can be expected in 0.1% of cases, depending on the patient's social status. It was possible to culture HSV-2 from the cervical secretion in 0.65% of an investigated group of pregnant women. Fifty percent of all infections in pregnancy are asymptomatic. Miscarriages are common before the 20th week of pregnancy (33%), while later there is a slight increase in premature confinement. Where HSV-2 infection exists at the time of birth, cesarean section is the method of choice for delivery. If rupture of the amnion has occurred over 4 hours previously surgical delivery to prevent infection is no longer justified. A start has been made on therapy for herpes genitalis and neonatal herpes, although sufficient experience for therapeutic recommendations has not yet been gathered.

Abortion, Spontaneous↗
PubMed1976

[Investigation of HL-antigens in cervical cancer patients (author's transl)].

Twenty-three of HL-antigens were investigated in 119 patients with clinical cancer and 230 female controls. Patients with cervical carcioma showed significant differences of some HLA frequencies from that of the controls. HLA-A 3 and A 28 were increased, HLA-A 1 was decreased. HL-antigens could be factors, together with others yet unknown, which produce an increased susceptibility to the disease.

Female↗
PubMed1976

A Mobile Laparoscopy Unit.

Our experience has led us to the construction of a Mobile Laparoscopy Unit. This unit increases safety and permits the adequate performance of laparoscopy. The Mobile Laparoscopy Unit is an alternative to a special laparoscopy room.

Germany, West↗
PubMed1975

[Seroepidemiological studies related to the association of genital herpes to cervical cancer (author's transl)].

Blood sera of 290 patients were examined for the presence of antibodies against herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2): 1. lues - seronegative individuals, 2. patients with specific lues antibodies, and 3. patients with so-called carcinoma in situ and invasive carcinoma of the uterine cervix. The group of syphilis-seropositive individuals served as control for the group with cervical lesions, because in both groups certain socioepidemiologic factors (promiscuity, early sexual intercourse) appear to be prevalent. The average value for HSV-2-antibodies was significantly higher in patients with cervical lesions than that in lues-seropositive individuals. Also, the average value was higher in the lues-seropositive group than that in the lues-seronegative group. The frequency of HSV-2-antibodies was highest in the group of patients with so-called carcinoma in situ and invasive carcinoma, less in the lues-seropositive group, and even more less in the lues-seronegative group. These results make it unlikely that the connection between cervical carcinoma and HSV-2-infection is a common or "nonsense"-correlation. They suggest a more narrow correlation between both diseases, but leave open whether it consists of either a causal relationship between herpes infection and the development of cervical carcinoma, or a predilection for herpes infection in the cervical region by the carcinomatous tissue.

Adult↗