Biomedical subjects
U Castiello
Publications and source records attributed to U Castiello.
Upper limb movement differentiation according to taxonomic semantic category.
The size or shape of an object, its perceptual features, determine the patterning of an arm and hand action involving that object. Little is known about the role played by the taxonomic semantic attributes of an object for perceptuomotor processing. In this study we investigated whether the semantic relationship between two target stimuli influences the kinematics of a bilateral reach-to-grasp action. The results showed that reach-to-grasp movements preceding the action of putting living-thing pairs together were faster, and showed earlier settings of reach and grasp temporal parameters, than movements involving pairs of non-living things. It is hypothesized that this reflects the recruitment of different categorical perceptuomotor pathways.
Reach to grasp: the response to a simultaneous perturbation of object position and size.
This study assessed the reach to grasp movement and its adaptive response to a simultaneous perturbation of object location and size. The aim was to clarify the means by which integration between the neural pathways modulating transport and manipulation is achieved. Participants (n = 11) were required to reach 30 cm to grasp a central illuminated cylinder of either small (0.7 cm) or large (8 cm) diameter. For a small percentage of trials (20/100) a visual perturbation was introduced unexpectedly at the onset of the reaching action. This consisted of a shift of illumination from the central cylinder to a cylinder of differing diameter (large in session A; small in session B) that was positioned 20 degrees to the left (n = 10 trials) or to the right (n = 10) of the central cylinder. The subject was required to grasp the newly illuminated cylinder. Movement duration for these "double" (position and size) perturbed trials was much longer than those of control trials to the central cylinder (session A: by an average of 250 ms; session B: 180 ms), and the increased values were much greater than those reported previously in "single" perturbation studies where either size or location of the object was perturbed. Initial signs of a response to the "double" perturbation were seen almost simultaneously in the transport parameter of peak arm deceleration and in the manipulation parameter of maximum grip aperture, but these changes were not evident until more than 400 ms after movement onset, a response onset much later than that found in "single" perturbation studies. It is proposed that the visual change resultant from the double perturbation activates integration centres that at first gate the flow of information to the parallel channels of transport and manipulation. Following processing of this information, these centres act to instigate a synchronised and coordinated response in both components. These results add support to the existence of neural centres dedicated to the integration of parallel neural pathways, and which exercise flexibility in the degree to which these components are "coupled" functionally.
Attentional coding for three-dimensional objects and two-dimensional shapes. Differential interference effects.
The role played by the attentional mechanisms that enable dominance of relevant objects over distractor objects was investigated by measuring changes in the kinematics of the reach-to-grasp movement. Subjects reached towards three-dimensional (3D) stimuli while attention was diverted towards distracting information consisting of either two-dimensional (2D) projected shapes or 3D objects. Movement kinematics were influenced to a greater degree when a secondary task was performed involving a 3D object rather than a 2D projected shape. When the distractor was 3D, both the reaching and the grasping components were altered but, when it was 2D only, the reaching component was modified. It is suggested that, when attention is directed towards a distractor, it is associated with interference in the kinematics of the action towards the target. Further, the nature and dimensions of the distractor selectively influence the reach or the grasp component of a prehension movement.
Kinematic analysis of the reach to grasp movement in Parkinson's and Huntington's disease subjects.
This experiment investigates the kinematic characteristics of the reach to grasp movement of Parkinson's and Huntington's disease subjects under two different experimental conditions. In the first condition subjects were required to perform the movement at a normal speed, while in the second condition they were required to perform the movement as fast as possible. Results showed that the kinematic parameterization of movement in Parkinson's disease subjects did not differ from that of age-matched control subjects for both the normal and the fast condition. However, the performances of Huntington's disease subjects appeared to be different when compared to the other two groups. Differences were mainly related to Huntington's disease patients' inability to properly define the temporal features of the movements.
The effect of unilateral posteroventral pallidotomy on the kinematics of the reach to grasp movement.
OBJECTIVE: To assess postoperative effects of unilateral posteroventral pallidotomy on the organisation of upper limb movement. METHODS: A three dimensional kinematic system (ELITE, B/T/S/ Italy) was used to record reach to grasp movements to objects of either small (0.7 cm) or large (8 cm) diameter placed at a reaching distance of either 20 or 30 cm. Four patients with Parkinson's disease were assessed in "off" (12 hours without medication) and "on" (1 hour after administration of medication) preoperatively and postoperatively. RESULTS: Duration of the movement and the time spent in arm deceleration were significantly reduced after surgery. However, movement patterning according to object size was adversely affected. Postoperatively, all four patients showed an abnormal pattern of a longer movement duration, and three showed a longer time of reaching arm deceleration, for reach to grasp movements to the large object than for those to the small object. CONCLUSION: Posteroventral pallidotomy seems to be beneficial in reducing bradykinesia of upper limb movements but may have "costs" to movement patterning, particularly for reach to grasp movements to objects of differing sizes. This study raises interesting questions about the role of the globus pallidus interna in coordinating stimulus bound visual information with appropriate motor patterning.
Prehension movements and perceived object depth structure.
This study asked the question, "Will the motor pattern to a perceived two-dimensional (2-D) object differ from that same object when it is perceived as three dimensional (3-D)?" Subjects were required to reach and grasp an apple that could appear to be 2-D or 3-D. Two experimental sessions were conducted. In Condition A, the apple was initially perceived to be 2-D, but, for 20% of trials, it suddenly shifted to a 3-D apple at movement onset. In Condition B, the apple was initially perceived to be 3-D, but, for 20% of trials, it suddenly shifted to a 2-D silhouette of the same apple. For control trials, subjects grasped the perceived 2-D apple as if it were a disc (82%), and they grasped the 3-D apple, as they would a normal apple, with a whole-hand grasp (86%). For Condition A perturbed trials, there was a rapid change from a 2-D precision grip to a 3-D whole-hand prehension, whereas the converse was true for the opposite perturbation. Peak acceleration was anticipated for Condition A perturbed trials but not for Condition B perturbed trials. These results indicate that the motor patterns we use in interacting with an object are strongly influenced by the way we perceive the object in real time, and that object affordances, such as dimension, can override the influence exerted by existing representations.
Dissociation of covert and overt spatial attention during prehension movements: selective interference effects.
In four experiments, the influence of distractor objects on the temporal evolution of the reach-to-grasp movement toward a target object (an apple) was examined. In the first experiment, the distractor was another apple, which moved laterally behind the target and occasionally changed direction toward the target, thus becoming the to-be-grasped object. In the second and third experiments, the distractor was a stationary piece of fruit, which sometimes became the to-be-grasped object because of a change in illumination. The fourth experiment was a combination of the first two experiments. In all cases, selective interference effects on the transport and manipulation components were observed only when attention to the distractor was covert rather than overt. It is proposed that covert visuospatial attention selects information about distracting but potentially important stimuli, such that a registration of significance is accomplished without the need to process all available information.
Arm and mouth coordination during the eating action in humans: a kinematic analysis.
The kinematic characteristics of the eating action in humans were assessed. Ten subjects were asked to bring to the mouth pieces of cheese of different sizes (0.7 cm and 2 cm). The pattern of mouth aperture with respect to the size of the food was similar to that found for grasping differently sized objects with the hand. Mouth aperture was appropriately scaled and the time of maximum aperture was reached earlier for the smaller than for the larger piece of cheese. The deceleration phase of the arm was prolonged when the small piece of cheese had to be brought to the mouth with respect to when the large piece of cheese had to be brought to the mouth. Temporal coupling between the time of maximum peak deceleration and the maximum mouth aperture was found in seven of the ten subjects. Taken together these preliminary results suggest that coordinated actions are subserved by the use of a common coordinating schema independently from the effectors involved.
The bilateral reach-to-grasp movement of Parkinson's disease subjects.
The performance of simultaneous movements is said to be disrupted in Parkinson's disease, yet there are some indications that this dysfunction is less evident for bilateral inter-limb actions, as opposed to unilateral simultaneous actions. Focussing specifically upon natural actions, this study uses a three-dimensional kinematics system (ELITE) to assess the movement kinematics of a bilateral non-homologous reach-to-grasp action. The target device consisted of a large cylinder (diameter 8 cm) to which a handle (diameter 0.8 cm) was attached. The task was to reach and grasp the cylinder with one hand (gross grasp) while reaching to grasp the handle with the contralateral hand (precision grasp). Overall the results indicated that Parkinson's disease subjects, like controls, showed independent and appropriate kinematic parameterization of each limb. For example, and as a reflection of task precision requirements, the time taken to decelerate upon the item to be grasped was longer for the limb grasping the handle than for the limb grasping the cylinder. Subtle indications of compensatory mechanisms, in response to left upper limb inadequacies of Parkinson's disease subjects, were suggested by findings of an earlier timing of maximum hand grip aperture for the left than for the right hand, and adjustments to the final transport phase of the left arm under bilateral conditions. It is proposed that left-right hand differences are more evident with basal ganglia dysfunction, but that these differences are compensated for by CNS mechanisms so that natural non-homologous reach-to-grasp actions are performed in a functional, coordinated and appropriate manner.
How perceived object dimension influences prehension.
A kinematic study assessed the effects of the perceived dimensions of an object upon the patterning of a prehension movement involving that object. If an apple was perceived as two-dimensional, subjects utilized a large precision grip between the index finger and thumb. If the apple was perceived as three-dimensional, whole hand prehension involving all the digits was utilized. A visual perturbation from perceived two-dimensional to three-dimensional at movement onset resulted in a transition from the 2D precision grip pattern to the 3D whole hand prehension. These results suggest that visual mechanisms for interpreting the dimension of an object directly influence motor selection pathways, and do not necessarily access a three-dimensional central nervous system representation of the object.
Three-dimensional covert attentional functions in Parkinson's disease subjects.
This study assessed the ability of mildly affected Parkinson's disease (PD) subjects (n = 16) to perform attentional cognitive tasks within a three-dimensional object. A hollow cube was displayed on a computer screen and the subject was required to respond as quickly as possible to the highlighting of one of the cube angles by pressing the spacebar of the keyboard. Prior to the appearance of this imperative stimulus, the same ("valid" trials) or an alternative ("invalid" trials) angle was highlighted. For the invalid trials this meant that the subject oriented attention to the cued angle but, on imperative stimulus appearance, was unexpectedly required to redirect attention to another angle, which could be on a different cube face to that which had been cued. For one experimental session the cube was stationary, that is, object-centred and viewer-centred coordinates of a cube angle corresponded. For another session, the cube rotated such that the viewer-centred coordinates of an angle changed between appearance of the cue and appearance of the stimulus, but the angle's object-centred coordinates remained constant. The finding of lower reaction times for the valid than for the invalid trials, even when the cube was rotating, indicated that PD subjects could operate attention using an object-centred coordinate system. However, PD subjects showed exaggerated reaction times when the stimulus appeared in a cube face that was opposite to, rather than the same as, that of the invalidly cued angle. It is suggested that this reflects a dysfunction in the grouping of the structural components of the whole object at an attentional level.
Grasping a fruit: selection for action.
This study used a natural task, with no emphasis placed on speeded responses, to investigate unconscious information processing. Using the ELITE system, a kinematic analysis was performed of the upper limb reach-to-grasp movement. Nine experiments explored how the presence of distractors affects the transport and grasp component of this movement. Experiment 1 showed that the kinematics for grasping apples, mandarins, cherries, and bananas were measurably different. Experiments 2A-D, 3, and 4 showed that these kinematics were not affected by the presence of nearby distractor fruits of either the same or a different kind. In Experiment 5, interference effects became evident when participants were required to perform a subsidiary task involving the distractor (counting the number of times a laterally placed fruit was illuminated). Experiment 6, requiring both grasping a target fruit and counting the number of times that this fruit was illuminated, revealed no interference effects. Taken together, these results suggest that selection for action does not involve substantial passive processing of distractors. However, dual-action processing of simultaneously presented objects does appear to involve automatic processing of even the task-irrelevant properties of the distractor.
A brain-damaged patient with an unusual perceptuomotor deficit.
When interacting with objects, the pattern of movements is influenced by such object characteristics as size and position. Little is known about the effect of higher level categorical encoding of objects upon movements. Here we present evidence for an approval-for-action process which takes into account such encoding. For the brain-damaged subject L.P., the ability to complete actions involving two objects in central vision is influenced by the semantic or functional relationship between the objects. Even though she perceives only one object, she can integrate two related objects into a coordinated action. If the objects are not related she is unable to integrate them into a single motor act. We propose that selection-for-action systems include processes which gate conceptually the behavioural disposition to action.
Reorganization of prehension components following perturbation of object size.
This study provides a kinematic comparison of the response of 12 older persons (ages 60-70) and 12 young persons (ages 20-26) to a perturbation of object size during a reach-to-grasp movement. For 80 out of 100 trials, each participant reached to grasp an illuminated cylinder of either small or large diameter (0.7 and 8.0 cm, respectively). For 20 out of 100 trials, a visual perturbation occurred at movement onset. This perturbation consisted of a switch of illumination from 1 to the other cylinder. For the switch from large to small cylinder, participants changed the distal grasp from whole-hand prehension to precision grip. For the opposite switch, participants changed from precision grip to whole-hand prehension. The older participants successfully adapted to these perturbations but showed a more conservative approach. Generally the approach time as the hand neared the object was prolonged, and the coordination between transport and manipulation components was maintained when comparing perturbed with nonperturbed trials. Young participants showed a more flexible pattern with a decrease or loss of temporal coupling between the components. It is hypothesized that the more rigid movement pattern of older participants to unanticipated motor requirements could be a contributory factor to the higher incidence of accidents for this group.
Covert visuospatial attentional mechanisms in Parkinson's disease.
Orienting and focusing of attention were assessed in 32 Parkinson's disease and 32 control subjects. No differences were found in the covert orienting of attention, suggesting that the Parkinson's disease subjects of the current study were not impaired in the ability to orient attention towards an expected source of stimulation. However, with the process of modulating the attentional focus or of managing more than one attentional task, dysfunction in Parkinson's disease subjects became apparent. The observed results are explained in terms of deficits in the relationship between task-related distribution of attentional resources and time efficiency of processing.
The drinking action of Parkinson's disease subjects.
Using the ELITE system, a kinematic analysis was performed of the upper limb drinking action of nine Parkinson's disease patients and nine control subjects. The aim was to use a natural task to investigate the reported Parkinson's disease dysfunction in the performance of simultaneous and sequential movements. Subjects were required to reach 28 cm, grasp a half-filled glass and then take a sip of water. Dysfunction for simultaneous movements was supported by the finding that, in both absolute and relative terms, Parkinson's disease subjects often began to open the hand later than control subjects. Dysfunction for sequential movements was supported by the finding that Parkinson's disease subjects often showed a pause between the first ('reach-grasp') and second ('take-to-lips') parts of the drinking action. Despite these delays and pauses, the proportional organization of the action was similar for both groups. This suggested that Parkinson's disease subjects were able to compensate for the problem in activating the different components of the drinking action. The results are discussed in relation to the influence of the abnormal basal ganglia input to cortical motor regions.
Perturbation of a prehension movement in Parkinson's disease.
Movement kinematics of the transport and manipulation components of a double-step prehension task were studied in eight Parkinson patients and eight control subjects. The aims were to (a) assess the effects of a spatial perturbation upon the movement for the two groups and (b) add data to the controversy about the damage/preservation of predictive behaviour in Parkinson patients. The results showed: (a) Both groups are able to preprogram a movement. (b) In both groups, the perturbation results in an anticipation of all kinematic parameters, both of the transport and manipulation components. (c) Parkinson patients, when adopting a predictive behavior, show a delay between the beginning of the two components, and thus activate them in sequence rather than simultaneously. This delay is significantly reduced by the perturbation, indicating that Parkinson patients, when using a responsive behavior, can recouple the two motor components.