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Biomedical subjects

U Caruso

Publications and source records attributed to U Caruso.

54 records · Page 3Linked to original sources
PubMed1988

Plasma levels of beta-endorphin in uraemic patients during haemodialysis.

Plasma levels of beta-endorphins (h-beta-END) are reported to increase under condition of stress. The authors have determined the plasma levels of h-beta-END in six uraemic patients before, during and after haemodialysis. They have found a significant increase at each subsequent time. It is suggested that the cause of the increasing h-beta-END concentrations is the intradialytic stress.

Adult↗
PubMed1985

Digestive tract endoluminal perfusion of cisapride (R 51619) and effects on gastrointestinal hormone levels in anaesthetized pigs.

The authors evaluated the in vivo effects of the new drug Cisapride on gastrointestinal hormone release in the mini-pig. Cisapride has been reported to stimulate and coordinate peristalsis of the GI tract. Selective endoluminal perfusion with Cisapride solution of the isolated but not denervated gastric antrum, duodenum and distal ileum demonstrated a significant increase of gastrin levels following perfusion of the gastric antrum and a decrease in vasoactive intestinal peptide following perfusion of the duodenum, only at very high doses.

Animals↗
PubMed1984

Hyperplasia of antral G cells in uraemic patients.

In this study we have performed a quantitative analysis of antral gastrin cells in 9 uraemic patients under dialytic treatment compared to a group of 10 chronic gastritis patients with a similar histological degree of gastritis. Immunocytochemistry was carried out on endoscopic biopsies of both groups. Using a computerised image analysing system we showed a significant increase of G-cell density (number of cells/mm2) in uraemic patients compared to non-uraemics (p less than 0.001). These findings provide a further morphological basis for the elevation of gastrin levels in chronic uraemic patients, suggesting the existence of a specific factor inducing G-cell proliferation in these patients.

Adult↗
PubMed1982

L-carnitine in haemodialysed patients. Changes in lipid pattern.

Carnitine is a selective carrier of free fatty acids from the cytoplasm to the mitochondria. Dialysed patients are chronically and progressively carnitine deficient due to loss in the dialysate. Simultaneously such patients present impaired lipid metabolism and this may provoke varied pathological conditions ranging from isolated hypertriglyceridaemia to frank forms of hyperlipoproteinaemia types IIa, IIb, and IV, and to apparently normolipaemic situations falling within a lipoprotein pattern tending to become pathological with low levels of HDL-cholesterol. In the present investigation we evaluated the effect of l-carnitine (versus placebo) on the lipid pattern in a group of apparently normolipaemic dialysed patients, but with altered coronary risk factors (HDL-cholesterol, beta:alpha lipoprotein ratio). Examinations showed no significant changes at the 15th and 30th day of placebo treatment, whereas the l-carnitine treated group displayed a statistical significant increase in HDL-cholesterol accompanied by reduced pre-beta-lipoproteins and decreased beta:alpha ratio.

Adult↗
PubMed1981

[Preliminary considerations on the occurrence of antigens of the HLA system in a group of chronic glomerulonephritis patients].

80 patients affected by Cronic Glomerulonephritis have been typed for HLA-A-B-C locuses, using a standard NIH Microfinphotoxicity Technique. 66 healthy blood donors have been types as controls. A significantly increased frequency of HLA-Bw35 has been reported in the patients group. Further analysis is needed for definite conclusions about linkage between this disease and HLA antigens.

Chronic Disease↗
PubMed1981

[Domperidone as an anti-emetic in antineoplastic chemotherapy].

The antiemetic effects of domperidone in patients undergoing post-surgical cytostatic treatment for stomach and colorectal carcinoma have been evaluated. The study has been performed on 3 groups of patients treated with domperidone, metoclopramide and placebo respectively. The antiemetic activity of domperidone proved to be better than that of metoclopramide. No side effects were observed in patients treated with domperidone.

Aged↗
PubMedDate not supplied

[Plasma amino acids in dialyzed children: comparison of hemodialysis and continuous ambulatory peritoneal dialysis].

Plasma protein and amino acid concentrations have been reported to be abnormal in patients with chronic renal failure, whether on conservative or regular dialysis treatment. These abnormalities may be related to impaired protein and amino acid metabolism associated with uremia, to dietary deficiencies of calories and proteins or to amino acid and protein losses due to peritoneal dialysis or hemodialysis. Plasma free amino acid concentrations were evaluated in 17 children undergoing hemodialysis (HD) and 13 children treated by continuous ambulatory peritoneal dialysis (CAPD). Plasma levels of free amino acids showed a reduction of EAA and of the ratio EAA/NEAA. There were some abnormalities in plasma amino acid concentrations; these included decreased levels of valine, threonine, lysine, serine, tyrosine, arginine, alpha-ABA. Aspartate, glycine, citrulline, and, only in HD, cystine and methionine were increased. Plasma protein and amino acid concentrations in CAPD patients are similar to those found in HD patients; thus they result poorly affected by different dialysis techniques and the uremic state itself seems to play a more decisive role.

Adolescent↗
PubMedDate not supplied

[Clinico-epidemiological findings in breast carcinoma in elderly patients].

Old age certainly represents one of the major risk factors for the development of neoplasia. In breast cancer the incidence rises with age and continues until the age of 84. In EEC countries approximately 140,000 new cases are reported every year and at the end of the 80s there were 10,983 deaths from breast cancer in Italy, an increase of over per 1000 women each year. Fifty par cent of new cases were diagnosed in women aged over 65. The efficiency of a screening programme is evaluated by the fall in mortality rates in the population included in the programme compared to that not included. Results from controlled studies have confirmed the efficacy of breast cancer screening in women aged between 50-70, showing a significant drop in mortality rates which range between 21 and 36%. Adequate diagnostic and therapeutic management are of primary importance and screening programmes are organised in highly efficient structures using specifically trained staff. This underlines the need to set up appropriate services and structures for the prevention and treatment of breast cancer in elderly women, given that the latter represent the most frequently affected age group. Old age should be considered a natural extension of life and all elderly women have the right to receive treatment to prevent breast cancer.

Adult↗