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Biomedical subjects

U C Rai

Publications and source records attributed to U C Rai.

30 records · Page 2Linked to original sources
PubMedDate not supplied

Effect of cowdung smoke inhalation on E.C.G. of rats.

The present study was conducted on 20 adult albino rats divided into group I (n = 10) and group II (n = 10). Group I animals were exposed to cowdung smoke for 60 min twice a day for a period of 75 days whereas group II served as control. ECG of control rats was essentially similar to that of man. ST segment was absent, Q wave absent or rudimentary and the mean QRS axis + 45 degrees. Rats exposed to cowdung smoke revealed a significant increase in PR interval and a mean QRS of + 117.5 degrees. Our results indicate that inhalation of cowdung smoke leads to conduction defects and right axis deviation.

Animals↗
PubMedDate not supplied

Electrocardiographic changes in experimental drowning.

Healthy mongrel dogs were subjected to aspiration of 20 ml/kg of fresh water (group I) or sea water (group II). Fresh water as well as sea water aspiration produced an immediate and significant bradycardia and the heart rate remained appreciably low throughout the forty minute study period. Appearance of tall T waves was the chief electro-cardiographic abnormality seen in both the groups. Out of seven dogs subjected to fresh water aspiration, two died of ventricular fibrillation and the other five survived. On the other hand, out of seven dogs subjected to sea water aspiration, five died of ventricular asystole within 10 min. This shows that equivalent volume of sea water is more lethal than fresh water. Further it is concluded that ventricular fibrillation is common after fresh water aspiration whereas sea water aspiration commonly leads to ventricular asystole.

Animals↗
PubMedDate not supplied

Production of myocardial lesions in a graded fashion by noninvasive technique in albino rats.

Systematic study of producing graded lesions of myocardium with the use of Isoproterenol (IPT) reveals that mild to severe degree of infarction can be induced by administering the compound for one to four consecutive days in the dose of 85 mg/kg body weight in rats. These findings differ slightly from those of Rona et al. where they have not attempted to produce the lesions in a graded fashion. The experimental period can be reduced to two days by using high dose (170 mg/kg), but such procedure increases significantly the mortality in these animals and lesions are not produced in graded fashion.

Animals↗
PubMedDate not supplied

Effect of cigarette smoking on leucocytes in South Indians.

A study was done on 200 male hospital employees of similar socio-economic status in the age group of 25-45 years. The smokers had a significantly higher total leucocyte count and there was a significant positive correlation (r = 0.388) between the quantity of cigarettes smoked and leucocyte count. Besides this a significant lymphocytosis and neutropenia was also observed. It is suggested that total leucocyte count may be taken as an index for the degree of smoking.

Adult↗
PubMedDate not supplied

Effect of cyproheptadine on bar-pressing for food reward in rats.

Lever pressing rate under a continuous reinforcement schedule for food reward in rats was reduced significantly by cyproheptadine in the dose of 5 and 10 mg/kg body weight. Under fixed ratio schedule of reinforcement, the responding was also suppressed significantly by 5 and 10 mg/kg body weight doses of cyproheptadine. However, high dose (20 mg/kg) of cyproheptadine administered subsequent to the low doses, failed to inhibit the bar pressing rate under either continuous or fixed ratio schedules.

Animals↗
PubMedDate not supplied

Cardiovascular effects of acetaldehyde in guinea pigs.

The hemodynamic effects of intravenous administration of acetaldehyde were determined in anesthetized control (group I), propranolol pretreated (group II) and phentolamine pretreated (group III) guinea pigs. Acetaldehyde produced an immediate and significant increase in mean arterial pressure followed by its progressive decrease resulting in hypotension. Heart rate increased significantly. In propranolol treated animals, acetaldehyde-induced tachycardia was not produced whereas in phentolamine treated animals, the initial pressor response was converted into a depressor one. Hence the increase in mean arterial pressure and heart rate produced by acetaldehyde are likely to be due to catecholamine release from adrenergic nerve endings.

Acetaldehyde↗
PubMedDate not supplied

Cardiovascular changes during varied thermal stress.

The effect of thermal stress on healthy mongrel dogs was studied at ambient temperatures of 40, 45 and 50 degrees C. At 40 degrees C there was a linear increase in cardiac output, heart rate and oxygen consumption and cardiovascular failure did not occur even after 6 hours of exposure. At 45 degrees C the circulation was hyperdynamic up to 60 min but at 90 min there was a steep fall in oxygen consumption, cardiac output, stroke volume and mean arterial pressure whereas heart rate increased significantly. At 50 degrees C the hyperdynamic changes reached peak values in 30 min; but by 60 min, there was a collapse of cardio-vascular function leading to rapid decline and ultimate death. It seems that the point at which there is a sudden fall in oxygen consumption, cardiac output, stroke volume and mean arterial pressure could be taken as an index of significant heat injury.

Animals↗
PubMedDate not supplied

Effects of aspirated and swallowed water in mongrel dogs subjected to fresh-water drowning.

The effects of aspiration or aspiration-cum-swallowing were studied in two groups of anesthetized dogs. Group I animals were subjected to aspiration (20 mlg/kg) whereas that of group II to aspiration (20 ml/kg) cum-swallowing (20 ml/kg) of fresh water. Aspiration produced decrease in plasma sodium and chloride whereas potassium, hemoglobin and haematocrit increased. These changes were transient and the values came back towards preaspiration level in the surviving animals. In animals subjected to aspiration-cum-swallowing, there was no initial increase in hemoglobin and hematocrit and both these values decreased significantly. The pattern of electrolyte changes was essentially similar to the aspiration group. All the animals in the two groups showed an immediate onset of significant asphyxia and acidosis that persisted throughout the period of observation. It is concluded that aspiration of 20 ml of fresh water per kg body weight produces only transient changes in hemoglobin, hematocrit and electrolyte balance, whereas the changes in arterial gas and pH are significant and persistent. It is further concluded that the swallowed water modifies the aspiration induced changes in fresh water drowning.

Animals↗