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Biomedical subjects

U Bracco

Publications and source records attributed to U Bracco.

6 recordsLinked to original sources
PubMed1994

Effect of triglyceride structure on fat absorption.

Stereospecific distribution of fatty acids on triacylglycerol structures influences the technological behavior of fats as well as their absorption fate. Long-chain fatty acids in external (sn-1 and sn-3) positions may impair fat absorption and therefore the physiological response to dietary fats. Lower digestibility of bovine milk fat compared with that of human milk is related to the different position of palmitic acid in both fats. Stereospecific analysis of cocoa butter and fats containing stearic acid of the stearic-oleic-stearic acid (SOS) type showed that long-chain saturated fatty acids are almost exclusively present in sn-1 and sn-3 positions, which could explain their impaired absorption and therefore their neutral effect on serum lipid in humans despite their saturation and chain length. The true energy value of these fats therefore needs to be verified in mixed diets.

Absorption↗
PubMedDate not supplied

Alternative lipids to usual omega 6 PUFAS: gamma-linolenic acid, alpha-linolenic acid, stearidonic acid, EPA, etc.

The intravenous administration of parenteral fat emulsions is widely used in total parenteral nutrition (TPN) to supply essential fatty acids and concentrated energy in a relatively small volume of isotonic solution. They contain very high amounts of linoleic acid and usually about 8% of alpha-linolenic acid calculated in the fat phase (10 or 20% of the total emulsion). Most of the time one emulsion is given as the sole source of fat, giving direct venous entry to a fatty acid composition substantially different from that encountered in a normal diet. Since the latter greatly influences the fatty acid composition of phospholipids which are critical determinants of membrane structural properties influencing a variety of membrane functions (Fig. 1) (enzyme activity, membrane transport, receptor function) and functional precursors of intracellular and intercellular mediators (diacylglycerols, prostaglandins, leukotrienes, hydroxy fatty acids), do we provide the right fatty acid at the right place and the right time for efficient cell cell interaction? In other words, given the three roles of fatty acids--energetic, structural, functional--are we using the best strategy to avoid imbalances between the three roles?

Animals↗