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Biomedical subjects

U Bonk

Publications and source records attributed to U Bonk.

49 records · Page 3Linked to original sources
PubMedDate not supplied

Fluorescence in situ hybridization studies on breast tumor samples for distinguishing between different subsets of breast cancer.

OBJECTIVES: To evaluate fluorescence in situ hybridization for distinguishing between malignant and benign breast tumors and determining genetic subgroups of breast cancers. STUDY DESIGN: Touch preparations from 94 surgically removed breast tumors (17 benign and 77 malignant) were hybridized with a DNA probe specific for centromeric DNA sequences of chromosome 1. Twenty samples were additionally hybridized with a chromosome 9-specific probe. RESULTS: We investigated the heterogeneity of the cell populations on the basis of the number of signals per nucleus. All benign tumors showed two signals per nucleus. In contrast, carcinomas revealed a broad spectrum of hybridization patterns. Some showed almost exclusively two signals per nucleus, and others exceeded four signals. CONCLUSION: The hybridization patterns of individual tumors can be used for defining different subsets of breast cancer. The results may have prognostic impact, leading to "molecular-cytogenetic grading" of breast cancer.

Breast Neoplasms↗
PubMedDate not supplied

Histopathology and biology of invasive mammary carcinoma.

The quality of pathology services is of crucial importance as the definitive diagnosis of cancer is almost invariably made by pathologists. It is possible with help of the guidelines for Breast Pathology Services of the European Union to improve the consistency of histological diagnoses and the quality of prognostic information.

Breast Neoplasms↗