Search PubMed⌕ Search

Biomedical subjects

U Berglund

Publications and source records attributed to U Berglund.

At least 37 records · Page 2Linked to original sources
PubMed1986

Influence on lipoprotein metabolism of the platelet inhibitory drug ticlopidine.

The influence of the platelet inhibitory drug Ticlopidine (T) (500 mg daily) on lipoprotein metabolism was investigated in a double-blind placebo-controlled study of 38 middle-aged men with incapacitating stable angina pectoris. The concentrations of cholesterol (C), phospholipid (PL) and triglyceride (TG) in plasma, and very low density (VLDL), low density (LDL) and high density lipoprotein (HDL) fractions were measured before and after 4 and 8 weeks of treatment. After 8 weeks of T treatment the levels of C, PL and TG were increased by 14%, 15% and 30%, respectively. These elevations were confined to the atherogenic VLDL and LDL fractions. The LDL level showed a continuous increase during the study. There were no changes in the HDL fraction. The present findings emphasize the necessity to investigate several risk factors in all attempts of prevention of atherosclerotic disease. Before and during long-term treatment with T monitoring of plasma lipoprotein levels are recommended.

Adult↗
PubMed1986

Impaired odor perception in tank cleaners.

The olfactory perception of 20 men (tank cleaners) exposed to petroleum products (while cleaning oil tanks) was examined. Office workers and watchmen were used as referents (N = 20 + 20). They were matched with regard to sex, age, and smoking habits. Odor detection thresholds and the perceived odor intensity of four odorous stimuli, pyridine, dimethyl disulfide (DMDS), n-butanol, and heating oil vapor (gas phase of heating oil heated to +40 degrees C), were determined. The results suggested that the tank cleaners had higher absolute odor thresholds for n-butanol and oil vapor than the referents. The psychophysical function of the tank cleaners and referents differed for all the tested substances in respect to odor intensity. The tank cleaners displayed an odor deficit analogous to the hearing loss known as "loudness recruitment," ie, normal perception of strong stimuli but impaired perception of weak stimuli. This odor deficit was therefore named "odor intensity recruitment" and seems, in tank cleaners, to be associated with occupational exposure to oil vapor.

Adult↗
PubMed1985

Effects of ticlopidine of platelet function in men with stable angina pectoris.

The effects of ticlopidine (T) (500 mg daily) on platelet function were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris. The in vitro platelet reactivity to aggregating agents, the platelet sensitivity to prostacyclin and the plasma levels of platelet specific proteins and fibrinogen were determined before and after 4 and 8 weeks of treatment. T exerted a potent inhibitory effect on ADP-and collagen-induced platelet aggregation. The effect of T was proportional to the pretreatment reactivity to ADP and collagen. The inhibitory effect of T on the epinephrine response was less pronounced. The plasma levels of beta-thromboglobulin, platelet factor 4 and fibrinogen were not influenced by T. The platelet inhibition of prostacyclin was potentiated by T, and it was demonstrated that T and prostacyclin had synergistic inhibitory effects on platelet aggregation.

Adenosine Diphosphate↗
PubMed1980

Established beta-adrenergic receptor blocking therapy and acute myocardial infarction. A clinical study of risks and benefits.

In order to evaluate the risks and benefits of continuing established therapy with beta-adrenergic receptor blocking drugs during acute myocardial infarction (AMI), 183 consecutive patients, 63 with (beta-blocker group) and 120 without (control group) this therapy, were studied. Detailed information on previous diseases, present symptoms, established medication, clinical and laboratory findings on admission and during the first 12 hours in the CCU was collected. The incidences of congestive heart failure, hypotension, AV blocks and ventricular arrhythmias were not significantly more common in the control group (8 vs. 28%, p less than 0.01). Thus, continuation of established therapy with beta-adrenergic receptor blocking drugs does not seem to increase the risk of complications after hospital admission for AMI. The reason for the low incidence of inferior wall infarction in the beta-blocker group is not clear but it cannot be excluded that when patients on beta-adrenergic receptor blocking therapy develop an inferior AMI, they may run a greater risk of sudden death.

Adrenergic beta-Antagonists↗
PubMed1978

Invariance of odor strength with sniff vigor: an olfactory analogue to size constancy.

Previous evidence has shown that detection threshold in humans and olfactory neural discharge rate in animal preparations both depend on flow rate of odorous vapor. But no data have been reported that show the effects of flow rate in humans on perceived odor strength at suprathreshold intensities. Subjects learned to inspire at two flow rates, one twice as great as the other, by adjusting (on a cathode ray tube) the transduced trace of a sniff-produced pressure change to match either of two target contours. They then made magnitude estimations of odor strength, while producing either weak or strong sniffs, for odorants presented over a wide range of concentrations via a specially designed sniff-bottle system. The odorant, diluted in diethyl phthalate, was n-butanol in two experiments and n-amyl acetate in two others. Subject-controlled flow rate had no effect on odor strength for either odorant. There was an apparent contradiction between these data and those on neural discharge rate that may, however, be resolved by adopting an odor constancy model: When sniff intensity varies during the olfactory exploration of an odor source, information about the rate at which odorant molecules are established at the receptor site is combined with information about sniff vigor so that the resulting percept is of invariant odor strength.

Acetates↗
PubMed1978

Olfactory self- and cross-adaptation: effects of time of adaptation on perceived odor intensity.

The time-course of self- and cross-adaptation of the olfactory system was investigated for two constant concentrations of three odorous substances. The substances (hydrogen sulfide, dimethyl disulfide, and pyridine) were matched, in a pilot experiment, with regard to perceived odor intensity. The time of adaptation was controlled by the number of inhalations (1-10). A two-step scaling method, involving cross-modality matching and numerical scaling of the matching continuum, was used for measuring perceived odor intensity during adaptation. The results show that the time-course function for self-adaptation seems to be an exponential function for two of the substances (H2S, DMDS), while for the third (pyridine) the form of the function is less distinct. Cross-adaptation between substances was found for the high concentrations, while for the low concentrations, hydrogen sulfide and dimethyl disulfide gave rise to pronounced cross-facilitation. The latter effect increased with time of adaptation.

Adaptation, Physiological↗