Search PubMed⌕ Search

Biomedical subjects

U Baandrup

Publications and source records attributed to U Baandrup.

At least 91 records · Page 5Linked to original sources
PubMed1982

Surgical treatment of bacterial endocarditis.

Valve replacement was performed during a 7-year period in 27 patients with acute or subacute infective endocarditis. Twenty-three patients had single valve affection--16 aortic and 7 mitral--and 4 patients had affection of both the aortic and mitral valves. Eight of the patients with aortic valve lesion had congenital aortic valve stenosis and 2 of the mitral patients had mitral prolapse. Two patients were operated upon only on the echocardiographic finding of valvular vegetations. The rest of the patients were operated because of cardiac insufficiency, intractable infection or peripheral embolization. Five patients died and 22 patients (82%) were discharged. One of these patients died in the follow-up period. The remaining 21 patients all belong to class I or II (NYHA) postoperatively. There were no cases of reinfection. Emphasis is placed on the use of echocardiography in detecting valvular vegetations, and the need to take the proper surgical action as a result of this finding, even in asymptomatic patients.

Adolescent↗
PubMed1982

Correlation of Electrophysiology and morphology in myocardial sarcoidosis. A case report.

A 44-year-old man with systemic sarcoidosis for 11 years developed myocardial sarcoidosis with left bundle branch block and recurrent ventricular tachycardia prior to death. Autopsy showed granulomas and fibrosis in the myocardium including the left ventricular free wall, septum and His bundle, particular the left bundle branch. This is in accordance with the ECG findings.

Adult↗
PubMed1982

Different reactivity and structure of the prestenotic and poststenotic aorta in human coarctation. Implications for baroreceptor function.

In eight humans with coarctation, fresh aortic tissue was examined pharmacodynamically. In four of these patients, and in 12 additional patients, the aorta above and below the coarctation was studied morphologically and compared with eight control aortas. By in vitro stimulation with potassium (127 mM), noradrenaline (18 microM), and prostaglandin F2 alpha (28 microM), postcoarctational aortic ring preparations showed a significantly greater contractility than precoarctational rings (p less than 0.05). Volumetric analysis showed significantly more collagen (P less than 0.01) and les smooth muscle mass (p less than 0.01) in the aorta above than below the coarctation. No significant differences were found between sections from the arch and distal to the ligamentum arteriosum in the normal aortas. We conclude that the precoarctational aortic wall is more rigid than the postcoarctational wall. This may influence baroreceptors in the upper vascular bed in such a way as to tolerate a higher pressure. This would explain the preoperative proximal hypertension, the paradoxic hypertension and the frequent lack of normalization of blood pressure postoperatively.

Adolescent↗
PubMed1981

[Reye's syndrome].

Explore the source record for details and available documents.

Child, Preschool↗
PubMed1981

Cardiac involvement in juvenile amaurotic idiocy--a specific heart muscle disorder. Histological findings in 13 autopsied patients.

Juvenile amaurotic idiocy (JAI) is a rare disorder of autosomal recessive inheritance. It belongs to the so called ceroid lipofuscinoses and the central nervous system is the largest organ. Only very few reports refer to the accumulation of lipopigment in the heart of JAI patients. This study describes the morphology of the heart from all 13 patients with JAI in Denmark who died within a seven year period; electrocardiographic findings are related to structural changes. All compartments of the heart were involved, including the conduction system. Not only very substantial deposition of lipopigment was found in the myocytes, but we have also observed striking amounts of calcium and cholesterol compounds indicating a restrictive type of heart muscle disorder. These structural changes are uniform from case to case. Because of the nature of the disease only rather poor information of the cardiac state is available in JAI patients. 11 patients showed some cardiac enlargement. In 6 patients abnormal P-waves were recorded in the ECG suggesting increased atrial and ventricular diastolic pressure. 2 patients had bradycardia, probably due to sinus node involvement, and one patient developed complete right bundle branch block. However, in the 4 patients in whom the cardiac conduction system could be examined histologically no evidence of disturbance of cardiac impulse formation and conduction was seen in the few standard ECG strips available in spite of extensive deposition of abnormal material throughout the conduction system. There seems to be a discrepancy between the relatively minor functional disturbances observed and the heavy morphological changes of the entire heart. This aspect, however, may well be altered by an intensified clinical observation and examination of JAI patients.

Adolescent↗
PubMed1981

Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. I: Morphological and morphometric aspects.

Three hundred and sixty-one biopsies obtained by bioptome from 201 patients with suspected cardiomyopathy were analysed morphologically, semiquantitatively, quantitatively, and statistically to ascertain whether or not histological examination provided a measurable pattern characterising the different forms of cardiomyopathy. In addition, we have tried to find out whether or not morphometry increases the diagnostic reliability. Heart from 29 cases (10 female and 19 male) who died as a result of road traffic accidents or other extracardiac causes were sampled, selecting specimens from sites usually biopsied during life. Of these biopsies, 16.1 per cent were of such poor quality that morphological categorisation was not possible. The mean size of biopsies was 0.79 mm2, and on average 1.38 mm2 of tissue was available per patient. The histological descriptions were grouped in eight entities; morphometric analysis of the endocardium, myocardium, and interstitium resulted in a more accurate evaluation of the morphological changes. Muscle fibre diameter showed distinct variance between several morphological groups, particularly between normal and pathological groupings and between right and left sided ventricular samples. The applied scoring system included the histological HOCM index (hypertrophic cardiomyopathy) which separated clearly this type of cardiomyopathy from other disorders. Small foci of chronic inflammatory cells were seen in 25 per cent of the biopsies and did not indicate myocarditis. This study did not confirm the possible existence of small vessel disease. Morphometric data permitted distinction between several histological groups but this did not apply to individual patients in veiw of a considerable degree of overlap of the pathological changes. Combining the various morphological features and applying measurements failed to establish a definite pattern for congestive cardiomyopathy (COCM), and alcoholic heart muscle disease could not be separated from COCM. It is, however, suggested that semiquantitative and morphometric methods are mandatory, not only to define more accurately the morphological changes, but also to provide the basis for additional biochemical, immunological, and virological analysis.

Adolescent↗
PubMed1981

Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. II: Comparison of histology and clinical/haemodynamic information.

Endomyocardial biopsies showing histological evidence of "ordinary" hypertrophy or changes compatible with congestive cardiomyopathy (COCM) were obtained from 125 patients. Statistical analysis compared histological/morphometric data with clinical/haemodynamic findings such as ejection fraction, left ventricular end-diastolic pressure, and length of history. Patients were grouped either according to the histological description or the clinical diagnosis. Comparison of the morphological description with the final clinical diagnosis was also undertaken. Follow-up of the patients was between two and 66 months. The results of the statistical analyses showed no correlation between quantitative, morphological assessment and either clinical information, that is length of history and subsequent course, or the haemodynamic variables. In 86 per cent of cases a rough agreement between the morphological description and the clinical diagnosis was obtained, but no specific pattern permitting a morphological diagnosis of COCM was established. The findings suggest that pronounced topographic variation in biopsy material exists and that, therefore, the severity of COCM or its prognosis cannot be assessed from histological changes.

Adolescent↗
PubMed1981

Electron microscopic investigation of endomyocardial biopsy samples in hypertrophy and cardiomyopathy. A semiquantitative study in 48 patients.

Electron microscopic and statistical analyses of 66 right ventricular biopsies from 48 patients were undertaken to investigate whether quantitative differences exist between those patients with "ordinary" myocardial hypertrophy and those suffering from a form of cardiomyopathy. The electron microscopic changes were scored and correlated with hemodynamic variables such as ejection fraction (EF), left ventricular end-diastolic pressure (LVEDP) and length of history. The patients were followed for an average of 22.5 months, permitting an assessment of prognosis. The results show that the three diagnostic groups--"ordinary" hypertrophy, hypertrophic cardiomyopathy (HOCM) and congestive cardiomyopathy (COCM)--overlap, but crossover of sarcomeres is more frequent in patients in whom HOCM is diagnosed. Except for a tenuous relationship between EF, and the electron microscopy (EM) (r = -0.46, p less than 0.1) and between LVEDP and EM score (r = 0.61, p less than 0.01), in the COCM group, no correlation could be established between EF, LVEDP and length of history when the patients were grouped according to histologic or clinical diagnosis. This study shows that the various claims regarding relationships between morphologic changes and the functional status of patients or prognosis cannot be confirmed.

Adult↗
PubMed1981

Experimental diabetic cardiopathy preventable by insulin treatment.

A quantitative histologic study of hearts from streptozotocin-diabetic and nondiabetic rats was performed. The diabetic rats comprised as group of poorly controlled and one of well-controlled insulin-treated animals. The relative amount of connective tissue was statistically significantly increased in the poorly controlled diabetic rats (p less than 0.01). In the well-controlled group of diabetic rats, the relative amount of connective tissue was the same as in the controls. The number of cells in tunica media of the larger intramural coronary arteries was statistically significantly increased in the diabetic rats in a poorly controlled state (p less than 0.01). There was no difference between the control group and the diabetic rats in a well-controlled metabolic state. Thrombosis or calcification in tunica media of the large intramural coronary arteries was not observed. The present study is reconcilable with the hypothesis of a diabetic cardiopathy and strongly emphasizes the importance of careful insulin treatment.

Animals↗
PubMed1979

Haemangioendotheliosarcoma of the heart. Diagnosis and treatment.

A case of haemangioendotheliosarcoma of the right atrium in a 28-year-old man is reported. The presence of a continuous murmur to the right of the sternum as a clue to the diagnosis is pointed out, and the usefulness of cardiac catheterisation and angiography in making diagnosis emphasised. Irradiation therapy with cobalt-60 had a palliative effect upon this malignant tumour.

Adult↗
PubMed1977

Sinus histiocytosis with massive lymphadenopathy.

The present case report brings to attention an unusual form of massive benign lymphadenopathy which can stimulate malignant lymphoma. The disease occurs mainly in children and is characterized by a protracted course with painless enlargement of the cervical lymph nodes, fever, leucocytosis, mild anaemia, raised erythrocyte sedimentation rate and hypergammaglobulinaemia. The diagnosis is confirmed by a quite distinct microscopic picture of the involved lymph nodes. SHML is considered to be an unusual response to an infection in an individual with abnormal host defence, though this is not confirmed by the investigations undertaken in the presented case.

Anemia↗
PubMed1977

Löffler's endocarditis and endomyocardial fibrosis--a nosologic entity?

The problem whether Löffler's endocarditis and endomyocardial fibrosis belong to the same disease spectrum or are separate entities is still under debate. Until recently it was believed that endomyocardial fibrosis was a disorder restricted to tropical areas. Three Danish patients are presented, two showing a continuous disease spectrum, one patient showing the fully developed endomyocardial fibrosis which is indistinguishable from endomyocardial fibrosis described from the tropical areas. Eosinophilia was present in all three patients. The findings described in these three patients lend support to the unitarian hypothesis that Löffler's endocarditis and endomyocardial fibrosis belong to the same disease spectrum, and that the eosinophilic granulocyte may be the underlying cause.

Adult↗