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Biomedical subjects

U B Hoyme

Publications and source records attributed to U B Hoyme.

At least 19 recordsLinked to original sources
PubMed2000

Immunotherapy of gynaecological high-risk human papilloma virus infection with human leukocyte ultrafiltrate.

OBJECTIVE: In this preliminary presentation the outcome of women following systemic treatment of cervical human papilloma virus (HPV) with a leukocyte ultrafiltrate is reported. METHODS: Cervical brush specimens of 819 women with low-grade CIN-1 were evaluated for HPV infection. HPV-positive patients were treated either by cone biopsy because of suspicious colposcopy or by antibiotics for symptoms of bacterial cervicitis. The remaining women were considered as asymptomatic carriers of HPV and underwent systemic therapy by a human leukocyte ultrafiltrate in a dosage of 5 IE, 6 times in the first 2 weeks, and additionally as a single dose at weeks 4, 6, 8 and 10. RESULTS: The leukocyte ultrafiltrate was administered to 97 HPV-positive women. In follow-up 88.7% were HPV negative at week 6; the remaining 11 women were tested negative after completion of a second course of therapy. CONCLUSIONS: These preliminary data on the successful treatment of HPV infection by a leukocyte ultrafiltrate are very promising but have to be supported by additional research.

Biopsy↗
PubMed1996

[Perioperative antibiotic prophylaxis in breast surgery: cefotiam versus clindamycin].

97 patients undergoing breast surgery received either 2 g cefotiam or 1200 mg clindamycin as i.v. singleshot application in the course of an open randomised comparison of parallel groups to evaluate the efficacy and tolerability of both antibiotic regimens. Both regimens proved to be well to-lerated and equally suitable for the prophylaxis of postoperative infections in breast surgery.

Adolescent↗
PubMed1993

[Single dose therapy of uncomplicated urinary tract infections in women. Remission rates with ciprofloxacin in two prospective randomized comparative studies].

In a prospective randomized study, the clinical effectiveness of ciprofloxacin at a single dose of 250 mg p.o. was compared with that of two oral doses of 250 mg bid administered for two days in women with urinary tract infection following gynecological procedures. A healing rate of 95% was achieved with both single-dose (n = 62) and two-day treatment (n = 65). In a further prospective randomized multicenter study, single-dose therapy with 250 mg of oral ciprofloxacin in women with uncomplicated urinary tract infection was compared with three days of ambulatory treatment with 2 x 250 mg/day. In the case of these patients, the diagnosis was made and treatment applied in the doctor's office by one of seven specialist gynecologists practicing in the city area of Essen. The healing rate of 78% (n = 46) achieved with single-dose treatment was significantly inferior to the 91% seen with the three-day regimen (n = 53, p < 0.05).

Adult↗
PubMed1993

[Erosion of the uterine artery--an unusual late complication 19 weeks after Cesarean section].

In a 30-year old para I, following uncomplicated Caesarean section in late pregnancy, recurrent haemorrhage occurred, which finally peaked as an arterial mass bleeding. The diagnosis of an arrosion of a large branch of the uterine artery was made by clinical and sonographic means. Therapy consisted in operative revision of the uterotomy and the uterus is saved. The possible causes of bleeding in the late puerperium are discussed.

Adult↗
PubMed1993

Sexually transmitted diseases in adult, non-pregnant women.

Most of the publications reviewed focus on human papillomavirus (HPV), and a small proportion on herpes simplex virus (HSV), Chlamydia trachomatis, as well as the syndromes of pelvic inflammatory disease and bacterial vaginosis. The present hypothesis associates cervical intraepithelial neoplasia (CIN)-1 with high oncogenic risk HPV types in less than 30% of cases; whereby CIN-2 and CIN-3 are associated with a 90% risk. However, on the basis of HPV types, four categories ['low risk' (HPV 6/11, 42, 43, 44); 'intermediate risk' (HPV 31, 33, 35, 51, 52, 58); 'high risk/HPV 16'; and 'high risk/HPV 18'] for the associated risk for a high-grade lesion or an invasive cancer can also be defined. In practice it appears efficient to re-evaluate patients with oncogenic types in association with low-grade cytology, as well as women with high-grade cytology or suspicious colposcopy in narrow intervals. Several reports have suggested that HPV genital infections are multifocal; however, HPV DNA was also found in the lymph nodes and in the granulocytes of women with cervical cancer, in ovarian and endometrial tissue, in tumours of the urinary bladder, and in mammary ductal carcinoma.

Adult↗
PubMed1993

[Perioperative preventive use of antibiotics in breast surgery: clindamycin vs. cefuroxime].

149 patients scheduled for breast surgery with an identified risk for infection received either 1.2 g Clindamycin (n = 79) or 1.5 g Cefuroxim given intravenously in a prospectively randomized fashion at induction of anaesthesia. Both drugs were well tolerated by all study patients. Postoperative fever was seen in one woman in the Clindamycin group vs. two women in the Cefuroxim group (n.s.). Serum and tissue levels measured 30 minutes after administration were within the therapeutic range for both antimicrobial substances.

Adult↗
PubMed1993

[Cefuroxime and cefoxitin in perioperative preventive use of antibiotics. A randomized study].

In a prospectively randomized study 243 patients scheduled for gynaecologic surgery received either 2 g Cefoxitin or 1.5 g Cefuroxim at induction of anaesthesia. Both drugs were well tolerated by all study patients. Post-operative fever was seen in seven women in the Cefuroxim group (n = 121) vs. three women in the Cefoxitin group (n.s., x2-test). Wound infection occurred in two women in each group. In result Cefuroxim probably can be recommended as an alternative replacing Cefoxitin in prophylaxis, so Cefoxitin can be reserved as potent antimicrobial substance for therapy of gynaecologic infections.

Adult↗
PubMed1992

[Chlamydia infection and salpingitis].

Chlamydia trachomatis is the most prevalent etiologic agent in women with uncomplicated salpingitis. This presentation reviews the current aspects of etiology, diagnosis, therapy, prevention and complications of this disease. The other clinical manifestations of chlamydial infection are also discussed.

Chlamydia Infections↗
PubMed1991

[Salpingitis].

The etiology of salpingitis is polymicrobial, however, the particular pathogen is difficult to identify, even in laparoscopically obtained specimens. Chlamydia trachomatis, Neisseria gonorrhoeae, anaerobes and facultative anaerobic bacteria have to be covered by antimicrobial therapy. This article reviews the current aspects of etiology, diagnosis, therapy, prevention and complications of salpingitis.

Anti-Bacterial Agents↗
PubMed1990

[Roxithromycin versus doxycycline in the treatment of cervicitis. Prospective randomized multicenter study under practice-related conditions].

In a prospective randomized multicenter study Roxithromycin 150 mg or Doxycycline 100 mg was given b.i.d. p.o. for ten days to women with clinically diagnosed cervicitis. All women were seen as outpatients by one of eight licensed gynecologists in their private office in the Essen city area. With a cure and improvement rate of 100% in those women who completed therapy, Roxithromycin (n = 106) was as effective as Doxycycline (n = 104; 98%). At 90% Roxithromycin was as well tolerated as Doxycycline at 93%. Both drugs were clinically and microbiologically effective in eradicating Chlamydia trachomatis.

Adult↗
PubMed1989

[Chlamydia infections].

Chlamydia trachomatis is a pathogen with an intracellular developmental cycle. Sexually transmitted infection with serotypes D to K can lead to cervicitis, endometritis, salpingitis and urethritis, however, symptoms are commonly mild. Newborns of mothers with cervical infection or colonisation can acquire inclusion conjunctivitis and atypical pneumonia. An efficient prophylaxis is not available so far. Antimicrobial therapy should be initiated as soon as chlamydial infection is confirmed, e.g. with tetracyclines or erythromycin. Partner treatment is mandatory.

Chlamydia Infections↗
PubMed1989

[Bacterial vaginosis].

Bacterial vaginosis is the most prevalent microbiological cause of vaginal discharge. Sexual intercourse is considered as a main risk factor, however, bacterial vaginosis is not a true sexually transmitted disease and characterized as a dysbalance in the vaginal microbiological ecosystem. The diagnosis is based on the characteristic vaginal discharge, a pH greater than 4.5, a positive whiff test and on presence of clue cells. In therapy nitroimidazoles p.o. are considered as treatment of choice. Bacterial vaginosis is a significant risk factor for ascending as well as postoperative and pre- and post-partum genital infections.

Bacteria↗