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Biomedical subjects

Troy E Dominguez

Publications and source records attributed to Troy E Dominguez.

5 recordsLinked to original sources
PubMed2004

S-100beta protein--serum levels in children with brain neoplasms and its potential as a tumor marker.

OBJECTIVE: To determine if serum S-100beta levels are elevated in children with brain neoplasms and if it can be used as a tumor marker for children with brain neoplasms. DESIGN: Prospective cohort study. SETTING: Urban, tertiary care, children's teaching hospital. PATIENTS: 136 healthy children and 27 children with brain neoplasms. METHODS: Serum levels of S-100beta were measured in 136 healthy children to serve as controls and 27 children with brain neoplasms, who underwent biopsy or resection of the mass. Patients were then classified into astrocytoma or non-astrocytoma groups. MEASUREMENTS AND MAIN RESULTS: The median serum S-100beta level for the control group was 0.27 mcg/l (range, 0.06-2.6 mcg/l), and for the brain neoplasm group was 0.2 mcg/l (range, 0.01-2.1 mcg/l), (p = 0.09). There were 13 children with astrocytomas and 14 with non-astrocytomas. The S-100beta levels for the astrocytoma group was 0.25 mcg/l (range, 0.05-1.1 mcg/l) and for the non-astrocytoma group 0.17 mcg/l (range, 0.01-2.1 mcg/l), (p = 0.47). CONCLUSIONS: Serum S-100beta levels are not elevated in children with brain neoplasms compared to healthy children, nor are they elevated in children with astrocytomas compared to non-astrocytomas. The S-100beta protein does not appear to be useful as a serum tumor marker in children with brain neoplasms.

Adolescent↗
PubMed2004

Cerebrospinal fluid levels of S-100beta in children and its elevation in pediatric meningitis.

OBJECTIVE: To describe normal cerebrospinal fluid (CSF) levels of S-100beta in children and determine whether CSF S-100beta levels are elevated in pediatric meningitis. DESIGN: Cohort study. SETTING: Children's teaching hospital. PATIENTS: A total of 141 children (107 controls and 34 meningitis patients). METHODS: CSF levels of S-100beta were measured in 107 control patients and 34 children with meningitis. S-100beta levels were measured in CSF collected from a lumbar puncture to evaluate for meningitis. Patients were classified as controls if they did not have pleocytosis or an organism identified. Patients were classified as having meningitis if there was CSF pleocytosis. Those with meningitis were then categorized as having bacterial or aseptic meningitis. S-100beta levels were measured by a commercial luminometric assay. Data are presented as median (interquartile range [IQ]) unless otherwise noted. MEASUREMENTS AND MAIN RESULTS: Normal CSF S-100beta levels were measured in 107 children with a median age of 2.6 months (1.4 months to 1.5 yrs). The median CSF S-100beta was 0.71 microg/L (IQ range, 0.48-1.07) with a tenth to 90th percentile range of 0.35-1.8 microg/L. A correlation was measured between age and CSF S-100beta levels in controls, (r2=.04, p=.037). Thirty-four children had meningitis with a median age of 4.0 yrs (2.0 months to 11.8 yrs). Ten were bacterial/mycobacterial, and 24 were aseptic. Children with meningitis had elevated S-100beta levels of 1.1 microg/L (IQ range, 0.9-1.6) compared with control levels of 0.71 microg/L (IQ range, 0.48-1.07) (p=.0001). Those with bacterial/mycobacterial meningitis had elevated S-100beta levels of 1.6 microg/L (IQ range, 0.78-3.0) compared with controls (p=.002). Children with aseptic meningitis also had S-100beta levels of 1.0 microg/L (IQ range, 0.91-1.4), which were elevated compared with controls, (p=.0003). CONCLUSIONS: CSF levels of S-100beta are elevated in children with meningitis compared with controls.

Adolescent↗
PubMed2002

Lemierre's syndrome: an unusual cause of sepsis and abdominal pain.

OBJECTIVE: To describe a patient with Lemierre's syndrome who presented with acute abdominal findings and to describe the evaluation and treatment of this syndrome. DESIGN: Case report. SETTING: A 38-bed, pediatric intensive care unit at a tertiary care children's hospital. PATIENT: One patient presenting with signs of severe sepsis and acute abdominal pain. INTERVENTIONS: Intravenous hydration, inotropic support, thoracostomy tube drainage of a pleural effusion, and prolonged antimicrobial therapy. MEASUREMENT AND MAIN RESULTS: The patient presented with severe sepsis and abdominal pain. After Fusobacterium necrophorum grew in blood cultures, anaerobic antimicrobial therapy was initiated. Doppler duplex ultrasonography and magnetic resonance venography demonstrated thrombus formation in the left internal jugular vein. Computed tomography of the chest demonstrated bibasilar lung nodules consistent with septic emboli. The patient was treated with ampicillin-sulbactam and metronidazole intravenously for 3 wks, followed by a 3-wk course of oral amoxicillin/clavulanate. He had a good recovery, and his thrombus had resolved at the time of discharge. CONCLUSION: Lemierre's syndrome occurs in young, otherwise healthy patients, and it thus needs to remain high on the differential diagnosis for this group of patients presenting with severe sepsis. The diagnosis can be confounded by a lack of symptoms of pharyngitis at the time of presentation and end-organ dysfunction associated with severe sepsis, suggesting alternative sources of infection.

Abdominal Pain↗