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Biomedical subjects

Thomas P Duffy

Publications and source records attributed to Thomas P Duffy.

10 recordsLinked to original sources
PubMed2005

Well rounded.

Team ward rounding is a time-honored practice. Trainees learn not only clinical aspects but also ethical values of patient care. Despite current emphases on the principles of professionalism and humanism in medicine, there remains little discussion about applying these principles to ward rounds. We believe that rounds can become classrooms for the intentional inculcation of professionalism and humanism as counterweights to unintentionally promulgated brusqueness, ambivalence, cynicism, and frustration. We gathered examples of "humanistic rounding" from various institutions that should stimulate discussion and illustrate that no specialized training is required to "humanize" rounds; rather, willingness and creativity are key ingredients.

Attitude of Health Personnel↗
PubMed2005

A clinician's approach to clinical ethical reasoning.

We offer a systematic strategy that situates clinical ethical reasoning within the paradigm of clinical reasoning. The trajectory of this strategy parallels clinical reasoning: a plain statement of the initial problem, careful gathering of data, a differential diagnostic assessment, and articulation and confirmation of a justified plan. This approach pays special attention to the goals of medical care, because so much depends on whether or not physician and patient share the same goals. This approach also addresses the heterogeneity of clinical problems that at first appear ethical and acknowledges the ethical pluralism that pervades clinical ethics.

Aged↗
PubMed2005

The Osler-Cushing covenant.

In 1900 William Osler established a friendship with Harvey Cushing that encompassed the personal and professional aspects of their lives for over two decades. Their shared participation in the covenant of medicine shaped an intense friendship and mentoring relationship that profited both individuals immeasurably. The choice of Cushing as the recipient of Osler's mentoring had its origins in their rearing, avocations, and in the way of life that they shared. In Cushing, Osler identified a surrogate son who joined with him in defining the course of medicine and surgery over the next century.

Education, Medical↗
PubMed2005

Oxaliplatin induces a delayed immune-mediated hemolytic anemia: a case report and review of the literature.

We report a case of a 59-year-old woman with metastatic carcinoma of the ileocecal region who received FOLFOX(oxaliplatin/leucovorin/5-fluorouracil) and bevacizumab therapy and exhibited a partial remission with minimal side effects. She developed a mild self-limited episode of immune-mediated hemolytic anemia during her 16th cycle of chemotherapy, which precluded her from receiving further oxaliplatin. We review the literature on oxaliplatin-induced immune-mediated hemolysis, including its mechanism, presenting symptoms, laboratory features, management, and implications for future therapy.

Anemia, Hemolytic↗
PubMed2004

Diabetes prevalence among Puerto Rican adults in New York City, NY, 2000.

This study assessed the prevalence of diagnosed diabetes and associated characteristics among Puerto Rican adults in New York City, NY, with a random-digit-dialed telephone survey with a dual-frame sampling design. Overall, 11.3% (95% confidence interval = 8.7%, 14.0%) had diagnosed diabetes; diabetes was significantly related to age, obesity, and family history; and the prevalence was high among those with the least education. This study showed the ability to obtain critically needed diabetes information from ethnic minorities at the local level.

Adolescent↗
PubMed2002

Lymphomas of mucosal-associated lymphoid tissue in common variable immunodeficiency.

Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by low serum immunoglobulins IgG, IgA, and usually IgM. The central immune deficiency is impaired secretion of immunoglobulins and lack of antibody production; however, T cell dysfunction and a variety of inflammatory complications suggest global immune dysregulation. A number of reports have documented the association of primary immunodeficiency diseases with the development of non-Hodgkin's lymphoma (NHL). In CVID, the risk has been estimated to lie between 1.4% and 7%. As for NHL arising in other immunodeficiency states, the lymphomas in CVID are extranodal and are usually B cell in type. Of 22 B cell lymphomas that have appeared over a period of 25 years in a cohort of subjects with CVID, five lymphomas, appearing in more recently studied subjects, that arose in mucosal sites would be classified as mucosa-associated lymphoid tissue (MALT) lymphomas. MALT lymphomas are low-grade B cell lymphomas that result from a proliferation of neoplastic marginal-zone related cells of lymphoid tissue and tend to occur in organs that have acquired lymphoid tissue due to long-term infectious or autoimmune stimulation. Lymphomas of this kind have not been described in patients with congenital immunodeficiency, although chronic mucosal antigen stimulation is an integral part of these immune deficiency states.

Adolescent↗
PubMed2002

Should disagreement about physician-assisted suicide discourage professional societies from engaging in public debate? A survey of 677 Connecticut internists.

OBJECTIVE: To determine whether physicians within a state-level professional association who disagree about the ethics of physician-assisted suicide (PAS) also disagree about organized professional engagement in public discussions regarding PAS. DESIGN: Anonymous mail questionnaire. PARTICIPANTS: Connecticut members of the American College of Physicians-American Society of Internal Medicine as of February 1999. MEASUREMENTS: Attitudes toward the legalization of PAS and organized participation in public discussions about PAS, and demographic and religious characteristics. MAIN RESULTS: The mean age of 677 respondents was 51 years and 20% were women. The legalization of PAS was favored by 28% of respondents, and opposed by 53%, but 84% favored organized participation in appropriate public discussions regarding PAS. Differences in religious affiliation were strongly associated with disagreements about PAS: physicians with Jewish affiliation or no affiliation were more likely to favor legalizing PAS than those with Catholic or other Christian affiliations (45%, 38%, 14%, and 19%, respectively, P < .001). Religious affiliation was not associated with differences in attitude toward organized participation in public discussions about PAS. Statistically significant differences in attitude toward public participation were found between some subgroups according to differing attitudes toward PAS, but in each case at least 80% of physicians still supported participation. CONCLUSIONS: Internists in this state-level organization widely supported organized participation in public discussions regarding PAS despite disagreements about its legalization, and support for organized participation was not affected by differences in religious affiliation nor substantially attenuated by differences in attitudes toward PAS.

Attitude of Health Personnel↗
PubMedDate not supplied

Pulmonary hypertension in type 1 Gaucher's disease: genetic and epigenetic determinants of phenotype and response to therapy.

Type 1 Gaucher's disease (GD) is recognized for striking but unexplained phenotypic diversity. Rarely, severe pulmonary hypertension (PH) may occur in GD but its clinical spectrum, determinants or its response to enzyme replacement therapy (ERT)+/-vasodilators is not known. One hundred and thirty-four consecutive patients with Type 1 GD were screened to estimate right ventricular systolic pressure (RVSP) by Doppler echocardiography. Ninety-four patients were on ERT and 40 were untreated. Eight additional GD patients were studied that represented consecutive tertiary referrals with severe PH. Angiotensin converting enzyme (ACE) gene polymorphisms and acid beta-glucosidase gene (GBA) mutations were determined by DNA analysis. Mild, asymptomatic PH (RVSP>35<50 mmHg) was prevalent in Type 1 GD: 30% in untreated patients and 7.4% among patients receiving ERT (P<0.001). Splenectomy was strongly associated with severe, life-threatening PH: all patients with severe PH (RVSP 50-130 mmHg) were asplenic compared to only 31% of patients with RVSP<50 mmHg (Odds ratio [OR] 28.8, 95% CI 1.6-531.6, P<0.001). Other characteristics of patients presenting with severe PH were poor compliance to ERT (4/9 patients) or no ERT (5/9 patients), a family history of a sib with GD and PH (2/2 patients), an excess of ACE I allele (OR 2.3, 95% CI 1.1-4.9, P=0.034) and an excess of non-N370S GBA mutation (OR 6.0, 95% CI 1.1-33, P=0.003). Severe PH was ameliorated by ERT+/-vasodilators during 4.6+/-4.0 yr (range 1-12 yr) follow-up; three patients were initially considered for lung transplantation but improved such that they are no longer active transplant candidates. Our study reveals a remarkable predisposition for PH in type 1 GD. Progression to severe, life-threatening PH occurs in the presence of additional genetic factors (non-N370S GBA mutation, positive family history, and ACE I gene polymorphism) and epigenetic modifiers (i.e., asplenia and female sex). Splenectomy should be avoided and in high-risk patients, ERT+/-vasodilators/coumadin should be initiated.

Adult↗