Extrarenal potassium transport.
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Animals↗
Biomedical subjects
Thomas Kahn
Publications and source records attributed to Thomas Kahn.
Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular cells: a histological, immunofluorescent, and ultrastructural study.
This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the hematoxylin-eosin and periodic acid-Schiff (PAS) stains. They were identified as kappa light-chains by immunofluorescent imaging and confirmed by immunoelectron microscopy. Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy.
Crystallization↗
Impact of the surgeon on the prevalence of arteriovenous fistulas.
Decreased use of native arteriovenous fistulas and an increased reliance on synthetic grafts as permanent dialysis access have accompanied the growth of the dialysis population in the United States, but not at our institution. Possible reasons for this difference were studied in a cross-sectional analysis in August of 2000. There were 51 chronic dialysis patients, all of whom had their access placed by the same surgeon; 75% of them were dialyzed through an arteriovenous fistula, which compares well with the 23% prevalence at the national level. Among our patients, 57% were diabetic, 98% had a history of hypertension, 35% had amputations or arterial bypass surgery, 37% had coronary artery disease, 12% had suffered a stroke, 35% were active smokers, and 22% had a history of intravenous drug use. The high prevalence of arteriovenous fistulas, despite so many comorbid conditions, suggests that the presence of a skilled and experienced surgeon may be more predictive of better dialysis access than other factors.
Aged↗
Proteus syndrome.
Proteus syndrome is a rarely described dysplasia syndrome of the group of congenital hamartomas that arises from mosaic mutation. An extraordinary case history including imaging studies will be reported. This 17-year-old girl suffered from cachexia, lifelong chronic obstipation, different dysplasias, and lipomatous tumor-like lesions. The following findings were marked: macrodactyly, nevi, hemihypertrophy, aggressive lipomatosis, hemangiomas of the spleen, and skull and cerebral malformations. Additionally, an intestinal affection with fatty wall thickening was detected. In contrast to reports in the literature describing a reduced lifespan with a mean of few years, our patient is still alive. The treatment should take a palliative symptomatic approach considering the clinical situation.
Adipose Tissue↗
Imaging after a whipple operation: improving visibility of the afferent jejunal loop in spiral computed tomography using biliary contrast medium.
OBJECTIVE: Spiral computed tomography (CT) examination of patients after a Whipple operation often raises questions concerning the afferent loop. This study evaluates the efficiency of biliary contrast medium (BCM) in visualizing opacification of this loop. METHODS: After undergoing a Whipple operation, 31 patients received 100 mL BCM before postoperative spiral CT (Somatom Plus 4; Siemens, Erlangen, Germany: 5- or 10-mm slices, feed of 7 or 12 mm/s; Volume Zoom; Siemens: 2.5 mm collimation, total feed of 15 mm/s). Semiquantitative evaluation included opacification of the jejunal loop and visibility of jejunostomies. Complications and tumor recurrences were recorded. RESULTS: In all patients, BCM was successfully administered without complications. Afferent loop opacification was seen in 95% of examinations with BCM versus 5% of examinations with oral contrast medium. Evaluation of jejunostomies was unequivocally facilitated by BCM. Three previously undetermined changes were identified as tumor recurrence, and recurrence was ruled out after examination with BCM in 7 cases. CONCLUSIONS: After a Whipple operation, opacification of the afferent loop can be regularly achieved by intravenous administration of BCM, which eases distinction of normal postoperative changes from local tumor recurrence. Administration of BCM is recommended as a standard diagnostic procedure in these patients.
Adult↗